Special Drug Use Observational Study With Beovu Kit for Intravitreal Injection

NCT ID: NCT05526729

Last Updated: 2025-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

222 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-02

Study Completion Date

2024-06-29

Brief Summary

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This was a primary data collection-based observational special drug-use surveillance to be conducted in accordance with the Good Post-marketing Study Practice (GPSP) ordinance.

Detailed Description

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This study aimed to evaluate the safety of Beovu kit for intravitreal injection in clinical use in diabetic macular edema (DME) patients.

The observation period was 1 year (52 weeks) from the first Beovu administration in the primary treated eye.

In patients discontinuing treatment with Beovu in the primary treated eye before Week 52, the following observation periods applied.

* Date of last Beovu dose + 90 days\* in primary treated eye \> Week 52: up to Week 52
* Date of last Beovu dose + 90 days\* in primary treated eye ≤ Week 52: up to last dosing date in the primary treated eye + 90 days \*90 days: to collect as much data as possible considering clinical effects

Conditions

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Diabetic Macular Edema

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Beovu

Patients prescribed with Beovu for diabetic macular edema

Beovu

Intervention Type OTHER

Prospective observational study. There was no treatment allocation. Patients prescribed with Beovu for the first time for diabetic macular edema were eligible to enroll into this study.

Interventions

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Beovu

Prospective observational study. There was no treatment allocation. Patients prescribed with Beovu for the first time for diabetic macular edema were eligible to enroll into this study.

Intervention Type OTHER

Other Intervention Names

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Brolucizumab

Eligibility Criteria

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Inclusion Criteria

1. Patients must provide written consent to cooperate in this study before the start of treatment with Beovu
2. Patients using Beovu for the first time for the following indication • Indication: diabetic macular edema

Exclusion Criteria

1\. Patients with a history of treatment with a drug containing the same ingredient (brolucizumab) as Beovu
Minimum Eligible Age

0 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Novartis Investigative Site

Nagakute, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Kashiwa, Chiba, Japan

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Kisarazu, Chiba, Japan

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Urayasu, Chiba, Japan

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Urayasu, Chiba, Japan

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Yoshida-gun, Fukui, Japan

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Fukuoka, Fukuoka, Japan

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Fukuoka, Fukuoka, Japan

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Kurume, Fukuoka, Japan

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Fukushima, Fukushima, Japan

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Mizunami, Gifu, Japan

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Maebashi, Gunma, Japan

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Asahikawa, Hokkaido, Japan

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Hakodate, Hokkaido, Japan

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Hakodat, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Kobe, Hyōgo, Japan

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Kobe, Hyōgo, Japan

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Nishinomiya, Hyōgo, Japan

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Sumoto, Hyōgo, Japan

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Takarazuka, Hyōgo, Japan

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Inashiki, Ibaraki, Japan

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Ishioka, Ibaraki, Japan

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Mito, Ibaraki, Japan

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Kita-gun, Kagawa-ken, Japan

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Kagoshima, Kagoshima-ken, Japan

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Yokohama, Kanagawa, Japan

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Nankoku, Kochi, Japan

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Arao, Kumamoto, Japan

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Kyoto, Kyoto, Japan

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Yokkaichi, Mie-ken, Japan

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Miyakonojō, Miyazaki, Japan

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Matsumoto, Nagano, Japan

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Ueda, Nagano, Japan

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Nagasaki, Nagasaki, Japan

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Nagasaki, Nagasaki, Japan

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Nagasaki, Nagasaki, Japan

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Kashihara, Nara, Japan

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Jōetsu, Niigata, Japan

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Sanjō, Niigata, Japan

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Ōita, Oita Prefecture, Japan

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Yufu, Oita Prefecture, Japan

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Kurashiki, Okayama-ken, Japan

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Okayama, Okayama-ken, Japan

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Hirakata, Osaka, Japan

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Moriguchi, Osaka, Japan

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Osaka, Osaka, Japan

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Ōsaka-sayama, Osaka, Japan

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Sakai, Osaka, Japan

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Suita, Osaka, Japan

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Iruma-gun, Saitama, Japan

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Ohtsu, Shiga, Japan

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Oda, Shimane, Japan

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Shimotsuke, Tochigi, Japan

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Bunkyo Ku, Tokyo, Japan

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Chiyoda-ku, Tokyo, Japan

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Edogawa City, Tokyo, Japan

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Hachiōji, Tokyo, Japan

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Hachiōji, Tokyo, Japan

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Itabashi-ku, Tokyo, Japan

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Katsushika-ku, Tokyo, Japan

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Musashino, Tokyo, Japan

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Taito-ku, Tokyo, Japan

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Toyama, Toyama, Japan

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Akita, , Japan

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Kumamoto, , Japan

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Kyoto, , Japan

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Okayama, , Japan

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Osaka, , Japan

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Osaka, , Japan

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Countries

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Japan

Related Links

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https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=18311

Results for CRTH258B1401 that is getting linked from the Novartis Clinical Trials Website

Other Identifiers

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CRTH258B1401

Identifier Type: -

Identifier Source: org_study_id

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