A Multi Center Study Comparing the Efficacy of CAD EYE and the Standard of Care (White Light )

NCT ID: NCT05523271

Last Updated: 2023-01-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-16

Study Completion Date

2023-08-30

Brief Summary

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This study is to assess the sensitivity and added benefits of CADEYE compared to standard care (white-light) in detecting colon polyps in patients undergoing colonoscopy.

Detailed Description

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Failure in polyp recognition is a major determinant for the high rate of missed colorectal neoplasms. In response, technological advances have paved the way for Computer-Aided Polyp Detection (CAD-e) systems. Artificial intelligence systems allow of real-time computer- aided detection of polyps with high-accuracy. CADEYE is a CAD-e system (FUJIFILM) that enables real-time video processing at the same rate as the standard procedure.

The data generated from this study will provide an estimate of the ADR throughout the Middle East as well as assess the accuracy of CADEYE in detecting adenomas in comparison to standard of care.

Conditions

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Colorectal Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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Patients undergoing White Light Endoscopy (standard of care)

All subjects in Experimental Arm A will undergo SOC (white-light endoscopy).

Group Type NO_INTERVENTION

No interventions assigned to this group

Patients undergoing CAD EYE endoscopy

All subjects in Experimental Arm B will undergo CADEYE endoscopy.

Group Type EXPERIMENTAL

CAD EYE (Computer Aided Diagnosis ----?

Intervention Type DIAGNOSTIC_TEST

CADEYE is a CAD-e system (FUJIFILM) that enables real-time video processing at the same rate as the standard procedure and and allows a real time computer aided detection of polyps with high accuracy.

Interventions

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CAD EYE (Computer Aided Diagnosis ----?

CADEYE is a CAD-e system (FUJIFILM) that enables real-time video processing at the same rate as the standard procedure and and allows a real time computer aided detection of polyps with high accuracy.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 40-80 years old subjects
* Subjects undergoing colonoscopy for the following: o Primary CRC screening

* Post-polypectomy surveillance
* Work up following FIT positivity
* Symptoms/signs suspicions of CRC
* Subjects must be willing to give written informed consent for the trial

Exclusion Criteria

* Unable to consent
* Contraindicated to undergo endoscopy
* Hospitalized patient
* Patients with the following conditions:

* History of colon resection
* History of CRC
* Antithrombotic therapy precluding colon resection o Inflammatory Bowel Disease (IBD)
* Familial Adenomatous Polyposis (FAP)
* Pregnant or lactating
* Poor bowel preparation: BBPS 0 or 1 in a segment
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Theodor Bilharz Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Mostafa Ibrahim

Mostafa Ibrahim

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Theodor Bilharz Research Institute

Giza, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Mostafa Ibrahim, M.D PhD

Role: CONTACT

01006107100

Farah Ebrahim, Medicine

Role: CONTACT

01066443936

Facility Contacts

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Mostafa Ibrahim, MD

Role: primary

00201006107100

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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CADEYE

Identifier Type: -

Identifier Source: org_study_id

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