Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
38 participants
INTERVENTIONAL
2023-12-05
2024-12-10
Brief Summary
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In this study, the investigators will examine whether brief increases in sympathetic activation result in immediate changes in plasma amyloid-beta levels in the five hours after exposure.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Stress (sympathetic nervous system activation)
Stress will be induced using the socially evaluated cold pressor test.
Participants will complete three rounds of the socially evaluated cold pressor test.
The socially evaluated cold pressor test involves submerging one hand in ice-cold water for 3 minutes while participants' reactions are filmed on camera.
Sympathetic Nervous System Activation
Participants will complete a task that increases sympathetic nervous system activation.
No-stress
Participants will hold a hand in room temperature water for 3 minutes.
No-stress
Participants will complete a task that will not affect their sympathetic nervous system activity.
Interventions
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Sympathetic Nervous System Activation
Participants will complete a task that increases sympathetic nervous system activation.
No-stress
Participants will complete a task that will not affect their sympathetic nervous system activity.
Eligibility Criteria
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Inclusion Criteria
* No chronic conditions or illness
* Taking no medications or drugs that might alter the stress response (e.g., corticosteroids, beta-blockers, and others)
* Not using any hormone-containing medication (e.g., hormonal contraceptives, hormone replacement, etc.)
* No contraindications for cold pressor test exposure (high blood pressure, heart disease, dysrhythmia, peripheral vascular disease, any other cardiovascular disorder, diabetes, vasculitis, lupus, tingling or numbness in the hands and/or feet, cryoglobulinemia, and Reynaud's phenomenon)
* No history of fainting during blood draws
* No phobia of having their blood drawn
* No general history of fainting or seizures
* Not currently diagnosed with a mood disorder (e.g., major depressive disorder)
* Not pregnant in the past 12 months
* Not lactating in the past 12 months
* Not trying to become pregnant if premenopausal
* Experienced natural menopause if postmenopausal
* Be non-smokers
* Be fluent in English
Exclusion Criteria
18 Years
65 Years
ALL
Yes
Sponsors
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Washington University School of Medicine
OTHER
Keck School of Medicine of USC
OTHER
University of Southern California
OTHER
Responsible Party
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Mara Mather
Professor of Gerontology, Psychology, and Biomedical Engineering
Locations
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University of Southern California
Los Angeles, California, United States
Countries
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Other Identifiers
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UP-22-00404
Identifier Type: -
Identifier Source: org_study_id
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