Development of IVF/ICSI Children Born From Different Endometrial Preparation Protocols
NCT ID: NCT05502770
Last Updated: 2025-09-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
700 participants
OBSERVATIONAL
2022-08-12
2025-12-31
Brief Summary
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Because there are many physiological and endocrinal differences in the frozen embryo transfer cycle with different endometrial preparation protocols, the development of children born from these regimens has received much attention. For example, there is a complete absence of the corpus luteum during the cycle of exogenous hormone administration. Or in the modified natural cycle, the pharmacokinetics is not entirely the same as the natural physiology when using an additional ovulatory injection with hCG. To date, there have been no longitudinal follow-up studies that evaluated and compared the long-term development of IVF/ICSI children born from frozen embryo transfer with different endometrial preparation protocols.
Thus, the investigators conduct a follow-up of our RCT to investigate the IVF/ICSI children born from frozen embryo transfer with different endometrial preparation protocols to give strong evidence about the safety of the three most common endometrial preparation protocols in women undergoing frozen embryo transfer.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Natural cycle children
Children born from frozen embryo transfer with natural cycle protocol
Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3
Ages \& Stages Questionnaires®, Third Edition (ASQ®-3) is a developmental screening tool designed for use by early educators and health care professionals. It relies on parents as experts, is easy-to-use, family-friendly and creates the snapshot needed to catch delays and celebrate milestones.
Physical development and General Health
Physical development and General health examination
Developmental Red flags
Developmental Red flags Questionnaires
Modified natural cycle children
Children born from frozen embryo transfer with modified natural cycle protocol
Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3
Ages \& Stages Questionnaires®, Third Edition (ASQ®-3) is a developmental screening tool designed for use by early educators and health care professionals. It relies on parents as experts, is easy-to-use, family-friendly and creates the snapshot needed to catch delays and celebrate milestones.
Physical development and General Health
Physical development and General health examination
Developmental Red flags
Developmental Red flags Questionnaires
Artificial cycle children
Children born from frozen embryo transfer with artificial cycle protocol
Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3
Ages \& Stages Questionnaires®, Third Edition (ASQ®-3) is a developmental screening tool designed for use by early educators and health care professionals. It relies on parents as experts, is easy-to-use, family-friendly and creates the snapshot needed to catch delays and celebrate milestones.
Physical development and General Health
Physical development and General health examination
Developmental Red flags
Developmental Red flags Questionnaires
Interventions
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Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3
Ages \& Stages Questionnaires®, Third Edition (ASQ®-3) is a developmental screening tool designed for use by early educators and health care professionals. It relies on parents as experts, is easy-to-use, family-friendly and creates the snapshot needed to catch delays and celebrate milestones.
Physical development and General Health
Physical development and General health examination
Developmental Red flags
Developmental Red flags Questionnaires
Eligibility Criteria
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Inclusion Criteria
* Parents agree to participate in the study.
Exclusion Criteria
6 Months
18 Months
ALL
Yes
Sponsors
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Mỹ Đức Hospital
OTHER
Responsible Party
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Principal Investigators
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Lan N Vuong
Role: STUDY_CHAIR
University of Medicine and Pharmacy at Ho Chi Minh City
Locations
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My Duc Hospital
Ho Chi Minh City, , Vietnam
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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09/22/DD-BVMD
Identifier Type: -
Identifier Source: org_study_id
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