The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma

NCT ID: NCT05496582

Last Updated: 2024-05-08

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-11-01
• Study Completion Date: 2026-12-31

Brief Summary

Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.

Detailed Description

This study will investigate the changes and associations in asthma. In this project, the investigators will explore the changes of gene expression of transgelin-2, metallothionein-2 and ezrin in asthma and investigate their correlation with current diagnosis markers of asthma, including pulmonary function, fractional exhaled nitric oxide,eosinophil counts,immunoglobulin E, interleukin-5, etc.

Conditions

Asthma

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

Asthma

Previously disgnosed asthma patients

No intervention

Intervention Type: DIAGNOSTIC_TEST

No intervention

Control

Healthy participants

No intervention

Intervention Type: DIAGNOSTIC_TEST

No intervention

Interventions

No intervention

No intervention

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

1. Males or females, aged 14-75 years;

2. Patients with a definite diagnosis of bronchial asthma;

3. The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;

4. Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;

5. Agree with all procedures in this trial by signing a written informed consent form.

Exclusion Criteria

1. Patients with chronic obstructive pulmonary disease or other airway disease;

2. Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;

3. Women who are known to be pregnant or breastfeeding;

4. Not willing to participate;

5. Psychiatric history and neurological disorders can not work normally;

6. Other conditions that the researcher considers inappropriate to participate in this study.

• Minimum Eligible Age: 14 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Xiangya Hospital of Central South University

OTHER

Sponsor Role: collaborator

National Natural Science Foundation of China

OTHER_GOV

Sponsor Role: collaborator

Shanghai University of Traditional Chinese Medicine

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Lei-Miao Yin, MD

Role: STUDY_CHAIR

Yueyang Hospital, Shanghai University of Traditional Chinese medicine

Jun-Tao Feng, MD

Role: STUDY_DIRECTOR

Xiangya Hospital of Central South University

Locations

Xiangya Hospital, Central South University

Changsha, Hunan, China

Site Status: RECRUITING

Yueyang Hospital, Shanghai University of Traditional Chinese Medicine

Shanghai, Shanghai Municipality, China

Site Status: NOT_YET_RECRUITING

Countries

China

Central Contacts

Lei-Miao Yin, MD

Role: CONTACT

collegeylm@shutcm.edu.cn

13774384237

Jun-Tao Feng, MD

Role: CONTACT

jtfeng1976@csu.edu.cn

13786145799

Facility Contacts

Jun-Tao Feng, MD

Role: primary

jtfeng1976@csu.edu.cn

13786145799

Lei-Miao Yin, MD

Role: primary

collegeylm@shutcm.edu.cn

13774384237

Other Identifiers

SHUTCM-0806

Identifier Type: -

Identifier Source: org_study_id