The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population

NCT ID: NCT05088512

Last Updated: 2023-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-23

Study Completion Date

2023-01-20

Brief Summary

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To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.

Detailed Description

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Unrelated Kazaks subjects who have bronchial asthma were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with bronchial asthma and normal control subjects free of bronchial asthma

Conditions

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Bronchial Asthma Genome Wide Association Studies

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental group:

Patients with bronchial asthma

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Control group

Patients without bronchial asthma

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Interventions

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SNP analysis of the DNA

SNP analysis of the DNA obtained from peripheral blood sample

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Persons with bronchial asthma confirmed by a doctor;
* The age of the patients is from 5 to 60 years;
* Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
* Persons who are able and willing to provide written informed consent;
* Persons capable and willing to comply with the research protocol;

Exclusion Criteria

* Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
* Pregnant or lactating women;
* Tuberculosis of any localization in the active phase and in history;
* Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
* Severe and decompensated course of endocrine diseases;
* Autoimmune diseases;
* Systemic diseases;
* Oncological diseases;
Minimum Eligible Age

5 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asfendiyarov Kazakh National Medical University

OTHER

Sponsor Role lead

Responsible Party

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Ildar Fakhradiyev

Project manager

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Kazakhstan

Almaty, , Kazakhstan

Site Status

Countries

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Kazakhstan

Other Identifiers

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1207

Identifier Type: -

Identifier Source: org_study_id

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