Secondhand Smoking in Asthmatic Children

NCT ID: NCT03099902

Last Updated: 2017-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-11-01

Study Completion Date

2015-09-01

Brief Summary

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This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.

Detailed Description

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Conditions

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Asthma in Children Wheezing

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Cases

Children with asthma/wheezing whose mothers were active smokers during pregnancy

Lung function

Intervention Type DIAGNOSTIC_TEST

Spirometry test

White blood cell DNA extraction

Intervention Type DIAGNOSTIC_TEST

GSTP1 and TNFa polymorphisms with PCR

Urinary testing

Intervention Type DIAGNOSTIC_TEST

Urinary nicotine and cotinine detection

Controls

Children without asthma/wheezing whose mothers were active smokers during pregnancy

Lung function

Intervention Type DIAGNOSTIC_TEST

Spirometry test

White blood cell DNA extraction

Intervention Type DIAGNOSTIC_TEST

GSTP1 and TNFa polymorphisms with PCR

Urinary testing

Intervention Type DIAGNOSTIC_TEST

Urinary nicotine and cotinine detection

Interventions

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Lung function

Spirometry test

Intervention Type DIAGNOSTIC_TEST

White blood cell DNA extraction

GSTP1 and TNFa polymorphisms with PCR

Intervention Type DIAGNOSTIC_TEST

Urinary testing

Urinary nicotine and cotinine detection

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Subjects 1-18 years old with doctor diagnosed asthma/wheezing

Exclusion Criteria

* Premature birth (\< 36 gestation weeks)
* Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)
Minimum Eligible Age

12 Months

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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AHEPA University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Maria Avgeri

MD, MSc, Clinical Research Associate

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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14/1-3-2011

Identifier Type: -

Identifier Source: org_study_id

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