Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis
NCT ID: NCT05496348
Last Updated: 2025-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
400 participants
OBSERVATIONAL
2022-10-20
2027-08-31
Brief Summary
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Upadacitinib (RINVOQ) is an approved drug for treating UC. Approximately 400 adult participants who are prescribed Upadacitinib by their physician in accordance with local label will be enrolled in Germany, Austria and Switzerland.
Upadacitinib will be administered in accordance with the terms of the local marketing authorization, and treatment of participants will be determined solely by the investigator. Participants in the study will be followed for up to 2 years.
There will be no additional burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and only data which are routinely collected during a regular visit will be utilized for this study.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Upadacitinib
Participants will receive upadacitinib as prescribed by their physician according to local label
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Participants initiating Upadacitinib (UPA) at the investigator's discretion as part of their routine clinical care; the decision to administer UPA must be made prior to and independent of documentation for the study and according to the approved local label.
* Participants able to understand and communicate with the investigator and comply with the requirements of the study.
* Participants willing to continue with study documentation after cessation of UPA.
Exclusion Criteria
* Participants previously exposed to a Janus kinase (JAK) inhibitor.
18 Years
ALL
No
Sponsors
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AbbVie
INDUSTRY
Responsible Party
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Principal Investigators
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ABBVIE INC.
Role: STUDY_DIRECTOR
AbbVie
Locations
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Kepler Universitaetsklinikum GmbH /ID# 251868
Linz, Upper Austria, Austria
Krankenhaus der Barmherzigen Brueder Wien /ID# 251867
Vienna, Vienna, Austria
Krankenhaus der Barmherzigen Brueder Salzburg /ID# 251869
Salzburg, , Austria
Universitaetsklinik Heidelberg /ID# 249922
Heidelberg, Baden-Wurttemberg, Germany
Praxis fuer Gastroenterologie /ID# 249917
Heidelberg, Baden-Wurttemberg, Germany
Rems-Murr-Klinikum Winnenden /ID# 278791
Winnenden, Baden-Wurttemberg, Germany
Klinikum Augsburg /ID# 249979
Augsburg, Bavaria, Germany
Medizinisches Versorgunszentrum Dachau /ID# 249945
Dachau, Bavaria, Germany
Klinikum rechts der Isar /ID# 262176
Munich, Bavaria, Germany
Dr.med. Johannes Behrendt Facharzt für Innere Medizin und Gastroenterologie /ID# 260516
Brandenburg, Brandenburg, Germany
Praxis Dr. Grümmer /ID# 249925
Potsdam, Brandenburg, Germany
Private Practice - Dr. Kempelmann /ID# 249935
Tostedt, Hamburg, Germany
Klinikum Darmstadt /ID# 267685
Darmstadt, Hesse, Germany
Praxis Dres. Hurst/Simonis /ID# 255421
Darmstadt, Hesse, Germany
Interdisziplinaeres Crohn Colitis Zentrum /ID# 252622
Frankfurt am Main, Hesse, Germany
Bethanien-Krankenhaus /ID# 260865
Frankfurt am Main, Hesse, Germany
Gastroenterologie Opernstrasse Private Practice - Dr. Falk & Krause & Kuhn /ID# 251822
Kassel, Hesse, Germany
Mueller/Mueller-Ziehm, Hanover /ID# 252617
Hanover, Lower Saxony, Germany
Medizinische Hochschule Hannover /ID# 254980
Hanover, Lower Saxony, Germany
Klinikum Lueneburg /ID# 249948
Lüneburg, Lower Saxony, Germany
Verein für Wissenschaft und Forschung /ID# 249928
Oldenburg, Lower Saxony, Germany
Private Practice - Dr. Mechthild Kemper & Dr. Markus Dreck /ID# 249916
Coesfeld, North Rhine-Westphalia, Germany
Evangelisches Krankenhaus Kalk /ID# 249987
Cologne, North Rhine-Westphalia, Germany
Gastroenterologische Gemeinschaftspraxis Herne /ID# 249990
Herne, North Rhine-Westphalia, Germany
Gastroenterologische Gemeinschaftspraxis Minden /ID# 249914
Minden, North Rhine-Westphalia, Germany
Dres. Mallach/Spelter /ID# 270912
Wuppertal, North Rhine-Westphalia, Germany
Benner & Dommermuth /ID# 249896
Koblenz, Rhineland-Palatinate, Germany
St. Marien- und St. Annastiftskrankenhaus /ID# 273172
Ludwigshafen am Rhein, Rhineland-Palatinate, Germany
Klinikum Worms gGmbH /ID# 269804
Worms, Rhineland-Palatinate, Germany
Gemeinschaftspraxis Drs. Denger und Pfitzner /ID# 249974
Friedrichsthal, Saarland, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 249971
Saarbrücken, Saarland, Germany
Klinikum Chemnitz - Flemmingstraße /ID# 259156
Chemnitz, Saxony, Germany
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 249989
Dresden, Saxony, Germany
Private Practice - Dr. Johannes Janschek /ID# 255092
Dresden, Saxony, Germany
Universitaetsklinikum Leipzig /ID# 262612
Leipzig, Saxony, Germany
Gesellschaft für klinische Studien /ID# 254081
Leipzig, Saxony, Germany
Praxisgemeinschaft Jerichow Schulze /ID# 262931
Jerichow, Saxony-Anhalt, Germany
Gemeinschaftspraxis im Medicum /ID# 249930
Altenholz, Schleswig-Holstein, Germany
Praxis S. Tetzlaff /ID# 253770
Buedelsdorf, Schleswig-Holstein, Germany
Thormann and Bethge /ID# 249897
Kiel, Schleswig-Holstein, Germany
Gastroenterologisch - Hepatologisches MVZ Kiel GmbH /ID# 252623
Kiel, Schleswig-Holstein, Germany
Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 249984
Lübeck, Schleswig-Holstein, Germany
Praxis fuer Gastroenterologie /ID# 249907
Lübeck, Schleswig-Holstein, Germany
Friedrich-Ebert-Krankenhaus GmbH /ID# 249973
Neumünster, Schleswig-Holstein, Germany
Gemeinschaftspraxis Dr. med. Maik Weisflog Dr. med. Katrin Ende /ID# 249918
Erfurt, Thuringia, Germany
Universitaetsklinikum Jena /ID# 253768
Jena, Thuringia, Germany
Universitaetsklinikum Jena /ID# 254371
Jena, Thuringia, Germany
Praxis Dr. Schiffelholz /ID# 252621
Augsburg, , Germany
MVZ Gastro Friedrichshain /ID# 249924
Berlin, , Germany
Praxis Dr. Berndt /ID# 252067
Berlin, , Germany
Dres. Schick/Wesenberg /ID# 249977
Berlin, , Germany
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 249981
Berlin, , Germany
Zweite Gemeinnuutzige Krankenhaus GmbH DRK Kliniken Berlin Kopenick /ID# 262849
Berlin, , Germany
Praxis S. Grüngreiff /ID# 249927
Berlin, , Germany
Praxis Dr. Soellenboehmer /ID# 249985
Berlin, , Germany
Praxis Dr. Spitz /ID# 252616
Berlin, , Germany
Krankenhaus Waldfriede /ID# 249900
Berlin-Zehlendorf, , Germany
Internist. Facharztp. Dr. Palmai /ID# 251821
Bitterfeld-Wolfen, , Germany
Alb-Donau Klinikum Blaubeuren, ADK GmbH für Gesundheit und Soziales /ID# 249923
Blaubeuren Abbey, , Germany
Frach/Hohaus, Dresden, DE /ID# 254979
Dresden, , Germany
Dres. Krause/Schiffer /ID# 251727
Frechen, , Germany
Dres. Bauer/Doerflinger /ID# 251568
Freiburg im Breisgau, , Germany
Internisten in Geldern /ID# 252068
Guelders, , Germany
Universitaetsklinikum Halle (Saale) /ID# 254083
Halle, , Germany
Private Practice - Dr. Matthias Eichler /ID# 249933
Hamburg, , Germany
Tappe/Miks/Delker, Hamm, DE /ID# 251729
Hamm, , Germany
Internistische Praxisgemeinschaft Hanau GbR /ID# 254079
Hanau, , Germany
Gastroenterologische Gemeinschaftspraxis /ID# 263633
Heilbronn, , Germany
Städtisches Kh. Heinsberg GmbH /ID# 252624
Heinsberg, , Germany
Praxis Dres. Preiss/Engelke /ID# 249919
Herne, , Germany
Praxis Dr. Schwarz /ID# 251819
Hettstedt, , Germany
MVZ Dres. Al-Kadi & Partner /ID# 249929
Iserlohn, , Germany
Praxis Dr. Weber /ID# 256099
Jena, , Germany
Gastroenterologe am Ettlinger Tor /ID# 249982
Karlsruhe, , Germany
MVZ Doceins West GmbH /ID# 249915
Koblenz, , Germany
MVZ Gastroenterologie Leverkusen /ID# 260512
Leverkusen, , Germany
Gastropraxis Magdeburg /ID# 249988
Magdeburg, , Germany
Praxis Dr. Burlefinger /ID# 259159
Munich, , Germany
Prof-med-stud.de /ID# 255419
Munich, , Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 249947
Münster, , Germany
Gastro Campus Research GbR /ID# 249983
Münster, , Germany
Praxis Dres Brendel /ID# 254078
Nuremberg, , Germany
Medius Klinik Nürtingen /ID# 255420
Nürtingen, , Germany
Pc Docs /Id# 249921
Pirmasens, , Germany
Elisabeth Klinikum GmbH /ID# 252264
Schmalkalden, , Germany
Praxis fuer Gastroenterologie /ID# 252615
Schwerin, , Germany
Dres. Rehbehn/Skusa /ID# 252618
Solingen, , Germany
bauchraum Gastroenterologisches Zentrum Dres. F. Kuehl, C. Hartmann, T. Klag BAG /ID# 251567
Stuttgart, , Germany
Dr. Schirin-Sokhan /ID# 259158
Würselen, , Germany
Zentrum fur Gastroenterologie und Hepatologie /ID# 260967
Zurich, Canton of Zurich, Switzerland
University Hospital Zurich /ID# 260966
Zurich, Canton of Zurich, Switzerland
EOC Ospedale Regionale Lugano /ID# 277165
Lugano, Canton Ticino, Switzerland
Inselspital, Universitaetsspital Bern /ID# 260968
Bern, , Switzerland
Berner IBD Study Group /ID# 262315
Bern, , Switzerland
Countries
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Central Contacts
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Related Links
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Related info
Other Identifiers
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P23-430
Identifier Type: -
Identifier Source: org_study_id
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