Study to Assess Change in Disease Activity of Risankizumab Treatment in Japanese Participants With Moderate to Severe Ulcerative Colitis

NCT ID: NCT07136116

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-09

Study Completion Date

2030-02-28

Brief Summary

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Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess the change in disease activity of risankizumab treatment in adult participants with moderate to severe UC in real-world clinical practice.

Risankizumab is an approved drug for treating participants with ulcerative colitis. Approximately 200 participants who are prescribed risankizumab by their physician in accordance with local label will be enrolled in approximately 30 sites across Japan.

Participants will receive risankizumab as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 156 weeks.

There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Detailed Description

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Conditions

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Ulcerative Colitis

Keywords

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Ulcerative colitis Risankizumab SKYRIZI

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Risankizumab

Participants will receive risankizumab as prescribed by their physician according to local label.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Participants with a diagnosis of moderate to severe Ulcerative Colitis (UC) commenced on Risankizumab (RZB) treatment prescribed as part of their routine clinical care at their clinical's discretion according to Japan approved label and treatment prescription recommendations/guidelines.
* The decision to prescribe RZB is made prior to and independently of study participation.
* Participants able to provide voluntary informed consent before any study-related activities or procedures (obtained/documented as per regulations). If the patient is under 18 years old, a patient's parent or legal guardian must be willing to give written informed consent.
* Participants who can understand and communicate with the investigator and comply with the requirements of the study, including collection of PRO data using a smart device (i.e., mobile phone) and continued PRO data collection after cessation of RZB.
* Participants without previous exposure to RZB.
* Participants who are not currently participating in interventional research (not including non-interventional studies, PMOS, or registry participation).
Minimum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Aichi Medical University Hospital /ID# 278155

Nagakute, Aichi-ken, Japan

Site Status RECRUITING

Nagoya University Hospital /ID# 278159

Nagoya, Aichi-ken, Japan

Site Status RECRUITING

Hirosaki University Hospital /ID# 278153

Hirosaki, Aomori, Japan

Site Status RECRUITING

Chiba University Hospital /ID# 277669

Chiba, Chiba, Japan

Site Status RECRUITING

Tsujinaka Hospital - Kashiwanoha /ID# 277672

Kashiwa-shi, Chiba, Japan

Site Status RECRUITING

Toho University Sakura Medical Center /ID# 277536

Sakura, Chiba, Japan

Site Status RECRUITING

Kyushu University Hospital /ID# 278077

Fukuoka, Fukuoka, Japan

Site Status RECRUITING

Sapporo Medical University Hospital /ID# 277535

Sapporo, Hokkaido, Japan

Site Status RECRUITING

Hokkaido University Hospital /ID# 277668

Sapporo, Hokkaido, Japan

Site Status RECRUITING

Sapporo Higashi Tokushukai Hospital /ID# 278123

Sapporo, Hokkaido, Japan

Site Status RECRUITING

Kobe University Hospital /ID# 278292

Kobe, Hyōgo, Japan

Site Status RECRUITING

Hyogo Medical University Hospital /ID# 277676

Nishinomiya-shi, Hyōgo, Japan

Site Status RECRUITING

University Hospital Kyoto Prefectural University of Medicine /ID# 277541

Kyoto, Kyoto, Japan

Site Status RECRUITING

Kansai Medical University Hospital /ID# 278619

Hirakata-shi, Osaka, Japan

Site Status RECRUITING

Saga University Hospital /ID# 278160

Saga, Saga-ken, Japan

Site Status RECRUITING

Saitama Medical Center /ID# 278076

Kawagoe, Saitama, Japan

Site Status RECRUITING

Shiga University of Medical Science Hospital /ID# 277540

Ōtsu, Shiga, Japan

Site Status RECRUITING

Hamamatsu University Hospital /ID# 277539

Hamamatsu, Shizuoka, Japan

Site Status RECRUITING

NHO Shizuoka Medical Center /ID# 278075

Sunto-gun, Shizuoka, Japan

Site Status RECRUITING

Dokkyo Medical University Hospital /ID# 278152

Mibu, Tochigi, Japan

Site Status RECRUITING

Institute of Science Tokyo Hospital /ID# 277538

Bunkyo-ku, Tokyo, Japan

Site Status RECRUITING

Kitasato University Kitasato Institute Hospital /ID# 278154

Minato-ku, Tokyo, Japan

Site Status RECRUITING

Kyorin University Hospital /ID# 277534

Mitaka-shi, Tokyo, Japan

Site Status RECRUITING

Fukuoka University Hospital /ID# 277677

Fukuoka, , Japan

Site Status RECRUITING

Sapporo Kosei General Hospital /ID# 278048

Sapporo, , Japan

Site Status RECRUITING

Countries

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Japan

Central Contacts

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AbbVie GK Clinical Trial Registration Desk

Role: CONTACT

Phone: +81-3-4577-1111

Email: [email protected]

Related Links

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Other Identifiers

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P25-797

Identifier Type: -

Identifier Source: org_study_id