A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

NCT ID: NCT03345849

Last Updated: 2022-11-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

526 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-07

Study Completion Date

2022-01-13

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in adults with moderately and severely active Crohn's disease (CD).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study includes two parts:

* Part 1: a randomized double-blind placebo-controlled induction period and
* Part 2: an extended treatment period for non-responders from Part 1.

In Part 1, participants will be randomized in a 2:1 ratio to upadacitinib 45 mg once daily (QD) or matching placebo for 12 weeks. The randomization will be stratified by baseline corticosteroid use (yes or no), endoscopic disease severity (Simplified Endoscopic Score for Crohn's disease \[SES-CD\] \< 15 and ≥ 15), and number of prior biologics with prior inadequate response or intolerance (0, 1, \> 1).

Participants who do not achieve clinical response at Week 12 will be able to enroll in Part 2 to receive a double-blind extended treatment with upadacitinib until Week 24. Clinical response is defined as a ≥ 30% decrease in average daily very soft or liquid stool frequency (SF) and/or ≥ 30% decrease in average daily abdominal pain (AP) score (both not worse than Baseline).

Participants who achieve clinical response at Week 12 may be eligible to enter the 52-week, double-blind, maintenance portion of Study M14-430 (NCT03345823).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Crohn's Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo

Participants will receive placebo once daily for 12 weeks in Part 1. Clinical non-responders will receive 45 mg upadacitinib once daily for 12 weeks in Part 2.

Group Type PLACEBO_COMPARATOR

Upadacitinib

Intervention Type DRUG

Oral; Tablet

Placebo for Upadacitinib

Intervention Type DRUG

Oral; Tablet

Upadacitinib

Participants will receive 45 mg upadacitinib once daily for 12 weeks in Part 1. Clinical non-responders will receive 30 mg upadacitinib once daily for 12 weeks in Part 2.

Group Type EXPERIMENTAL

Upadacitinib

Intervention Type DRUG

Oral; Tablet

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Upadacitinib

Oral; Tablet

Intervention Type DRUG

Placebo for Upadacitinib

Oral; Tablet

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

ABT-494 RINVOQ

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Confirmed diagnosis of CD for at least 3 months prior to Baseline.
* Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score.
* Evidence of mucosal inflammation based on the Simplified Endoscopic Score for Crohn's disease (SES-CD) on an endoscopy confirmed by a central reader.
* Demonstrated an inadequate response or intolerance to one or more conventional and/or biologic therapies (oral locally acting steroids, intravenous or oral corticosteroids, immunosuppressants or biologic therapies for CD), in the opinion of the investigator.

* Note: Participants who have had inadequate response or intolerance to conventional therapy who have received prior biologic may be enrolled; however, participants must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease).
* If female, participant must meet the contraception recommendations.

Exclusion Criteria

* Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
* Participant not on stable doses of CD related antibiotics, oral aminosalicylates, corticosteroids or methotrexate (MTX).
* Participant with the following ongoing known complications of CD: abscess (abdominal or peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, \> 2 entire missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, sigmoid and left colon, and rectum, or any other manifestation that might require surgery while enrolled in the study.
* Participant with ostomy or ileoanal pouch.
* Participant diagnosed with conditions that could interfere with drug absorption including but not limited to short gut or short bowel syndrome.
* Screening laboratory and other analyses show abnormal results.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

East View Medical Research, LLC /ID# 171176

Mobile, Alabama, United States

Site Status

CB Flock Research Corporation /ID# 166185

Mobile, Alabama, United States

Site Status

Delsol Research Management, Ll /Id# 170145

Chandler, Arizona, United States

Site Status

HonorHealth Research Institute - Shea /ID# 164821

Scottsdale, Arizona, United States

Site Status

Arizona Arthritis & Rheumatology Research, PLLC /ID# 164803

Sun City, Arizona, United States

Site Status

Southern California Res. Ctr. /ID# 169655

Coronado, California, United States

Site Status

Citrus Valley Gastroenterology /ID# 166173

Covina, California, United States

Site Status

Hoag Memorial Hosp Presbyterian /ID# 222540

Irvine, California, United States

Site Status

United Medical Doctors /ID# 207449

Los Alamitos, California, United States

Site Status

Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164762

Los Angeles, California, United States

Site Status

Facey Medical Foundation /ID# 203136

Mission Hills, California, United States

Site Status

United Medical Doctors - Murrieta /ID# 164945

Murrieta, California, United States

Site Status

Ucsd /Id# 164910

San Diego, California, United States

Site Status

Medical Assoc Research Grp /ID# 169706

San Diego, California, United States

Site Status

Univ of California San Francis /ID# 164944

San Francisco, California, United States

Site Status

Care Access Research /ID# 167767

San Pablo, California, United States

Site Status

Peak Gastroenterology Associates, PC /ID# 170143

Colorado Springs, Colorado, United States

Site Status

Delta Waves, Inc. /ID# 164776

Colorado Springs, Colorado, United States

Site Status

Western States Clinical Res /ID# 164760

Wheat Ridge, Colorado, United States

Site Status

Medical Research Center of CT /ID# 164926

Hamden, Connecticut, United States

Site Status

Clinical Research of West Florida, Inc /ID# 205827

Clearwater, Florida, United States

Site Status

Clinical Research of West Florida, Inc /ID# 208118

Clearwater, Florida, United States

Site Status

Advanced Research - Coral Springs /ID# 218021

Coral Springs, Florida, United States

Site Status

Encore Borland-Groover Clinical Research /Id# 203499

Jacksonville, Florida, United States

Site Status

Ctr for Advanced Gastroenterol /ID# 165353

Maitland, Florida, United States

Site Status

Crystal Pharmacology Research /ID# 166081

Miami, Florida, United States

Site Status

Coral Research Clinic /ID# 164890

Miami, Florida, United States

Site Status

Advanced Research Institute, Inc /ID# 164921

New Port Richey, Florida, United States

Site Status

Endoscopic Research, Inc. /ID# 206136

Orlando, Florida, United States

Site Status

Omega Research Maitland, LLC /ID# 203481

Orlando, Florida, United States

Site Status

Clinical Research Trials of Florida, Inc. /ID# 203485

Tampa, Florida, United States

Site Status

AdventHealth Tampa /ID# 171167

Tampa, Florida, United States

Site Status

Gastroenterology Associates of Central Georgia, LLC /ID# 165478

Macon, Georgia, United States

Site Status

Gastroenterology Consultants PC - Roswell /ID# 218220

Roswell, Georgia, United States

Site Status

Atlanta Gastroenterology Spec /ID# 164799

Suwanee, Georgia, United States

Site Status

Treasure Valley Medical Research /ID# 215032

Boise, Idaho, United States

Site Status

Rush University Medical Center /ID# 165497

Chicago, Illinois, United States

Site Status

University of Chicago Medicine /ID# 165503

Chicago, Illinois, United States

Site Status

DuPage Medical Group /ID# 205328

Downers Grove, Illinois, United States

Site Status

MediSphere Medical Research Center /ID# 166175

Evansville, Indiana, United States

Site Status

Indianapolis Gastroenterology /ID# 164938

Indianapolis, Indiana, United States

Site Status

University of Iowa Hospitals and Clinics /ID# 165436

Iowa City, Iowa, United States

Site Status

Tri-State Gastroenterology /ID# 165496

Crestview Hills, Kentucky, United States

Site Status

University of Louisville /ID# 165366

Louisville, Kentucky, United States

Site Status

University of Louisville /ID# 168572

Louisville, Kentucky, United States

Site Status

CroNOLA, LLC /ID# 164823

Houma, Louisiana, United States

Site Status

Nola Research Works, LLC /ID# 164759

New Orleans, Louisiana, United States

Site Status

Louisana Research Center, LLC /ID# 164894

Shreveport, Louisiana, United States

Site Status

Johns Hopkins University School of Medicine /ID# 211941

Baltimore, Maryland, United States

Site Status

MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 164935

Chevy Chase, Maryland, United States

Site Status

Gastro Center of Maryland /ID# 171161

Columbia, Maryland, United States

Site Status

Lahey Hospital and Medical Center /ID# 214726

Burlington, Massachusetts, United States

Site Status

University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164943

Ann Arbor, Michigan, United States

Site Status

Digestive Health Associates (DHA) - Farmington Hills /ID# 205793

Farmington Hills, Michigan, United States

Site Status

Center for Digestive Health /ID# 164822

Troy, Michigan, United States

Site Status

Clin Res Inst of Michigan, LLC /ID# 170133

Troy, Michigan, United States

Site Status

Mayo Clinic - Rochester /ID# 164783

Rochester, Minnesota, United States

Site Status

Southern Therapy and Advanced Research (STAR) LLC /ID# 165343

Jackson, Mississippi, United States

Site Status

Quality Clinical Research Inc. /ID# 170137

Omaha, Nebraska, United States

Site Status

Duplicate_CHI Nebraska d/b/a CHI Health /ID# 168578

Omaha, Nebraska, United States

Site Status

Las Vegas Medical Research /ID# 168588

Las Vegas, Nevada, United States

Site Status

AGA Clinical Research Associates, LLC /ID# 164769

Egg Harbor, New Jersey, United States

Site Status

Rutgers Robert Wood Johnson /ID# 166073

New Brunswick, New Jersey, United States

Site Status

NY Scientific /ID# 164931

Brooklyn, New York, United States

Site Status

United Health Services Hospitals, Inc /ID# 217485

Johnson City, New York, United States

Site Status

NYU Langone Long Island Clinical Research Associates /ID# 164927

Lake Success, New York, United States

Site Status

The Mount Sinai Hospital /ID# 170257

New York, New York, United States

Site Status

Columbia Univ Medical Center /ID# 164782

New York, New York, United States

Site Status

Gastoenterology Group of Rochester /ID# 166177

Rochester, New York, United States

Site Status

Richmond University Medical Center /ID# 201857

Staten Island, New York, United States

Site Status

Montefiore Medical Center - Moses Campus /ID# 166193

The Bronx, New York, United States

Site Status

Advantage Clinical Trials /ID# 168546

The Bronx, New York, United States

Site Status

Atrium Health Carolinas Medical Center /ID# 164932

Charlotte, North Carolina, United States

Site Status

PMG Research of Charlotte /ID# 171160

Charlotte, North Carolina, United States

Site Status

Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164904

Raleigh, North Carolina, United States

Site Status

Wake Forest Baptist Medical Center /ID# 164908

Winston-Salem, North Carolina, United States

Site Status

Plains Clinical Research Center, LLC /ID# 170140

Fargo, North Dakota, United States

Site Status

Gastro Health Research /ID# 164791

Cincinnati, Ohio, United States

Site Status

University of Cincinnati /ID# 164825

Cincinnati, Ohio, United States

Site Status

Cleveland Clinic Main Campus /ID# 209231

Cleveland, Ohio, United States

Site Status

The Ohio State University /ID# 170141

Columbus, Ohio, United States

Site Status

Optimed Research, Ltd. /ID# 205624

Columbus, Ohio, United States

Site Status

Hometown Urgent Care and Resea /ID# 201291

Dayton, Ohio, United States

Site Status

Dayton Gastroenterology, Inc. /ID# 167627

Englewood, Ohio, United States

Site Status

Great Lakes Medical Research, LLC /ID# 202010

Mentor, Ohio, United States

Site Status

Digestive Disease Specialists /ID# 201064

Oklahoma City, Oklahoma, United States

Site Status

Options Health Research, LLC /ID# 164820

Tulsa, Oklahoma, United States

Site Status

Healthcare Research Consultant /ID# 166195

Tulsa, Oklahoma, United States

Site Status

University of Pennsylvania /ID# 168430

Philadelphia, Pennsylvania, United States

Site Status

Pharmacorp Clinical Trials /ID# 164916

Charleston, South Carolina, United States

Site Status

Gastroenterology Associates, P.A. of Greenville /ID# 164771

Greenville, South Carolina, United States

Site Status

Rapid City Medical Center - GI Research /ID# 201735

Rapid City, South Dakota, United States

Site Status

Gastro One /ID# 164826

Germantown, Tennessee, United States

Site Status

East Tennessee Research Institute /ID# 203613

Johnson City, Tennessee, United States

Site Status

Quality Medical Research /ID# 205263

Nashville, Tennessee, United States

Site Status

Vanderbilt University Medical Center /ID# 164946

Nashville, Tennessee, United States

Site Status

TX Clinical Research Institute /ID# 164896

Arlington, Texas, United States

Site Status

Inquest Clinical Research /ID# 164785

Baytown, Texas, United States

Site Status

Texas Digestive Disease Consultants /ID# 209953

Cedar Park, Texas, United States

Site Status

Texas Digestive Disease Consultants /ID# 209801

Cedar Park, Texas, United States

Site Status

Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170144

Dallas, Texas, United States

Site Status

CliniCore International, LLC /ID# 164902

Houston, Texas, United States

Site Status

Baylor College of Medicine - Baylor Medical Center /ID# 164947

Houston, Texas, United States

Site Status

Centex Studies, Inc. - Houston /ID# 201214

Houston, Texas, United States

Site Status

GI Specialists of Houston /ID# 202339

Houston, Texas, United States

Site Status

Caprock Gastro Research, LLC /ID# 215438

Lubbock, Texas, United States

Site Status

Clinical Associates in Research Therapeutics of America, LLC /ID# 164786

San Antonio, Texas, United States

Site Status

Southern Star Research Institute, LLC /ID# 169755

San Antonio, Texas, United States

Site Status

Carl R. Meisner Medical Clinic /ID# 201061

Sugar Land, Texas, United States

Site Status

Tyler Research Institute, LLC /ID# 168687

Tyler, Texas, United States

Site Status

Gastro Health & Nutrition - Victoria /ID# 167812

Victoria, Texas, United States

Site Status

HP Clinical Research /ID# 164933

Bountiful, Utah, United States

Site Status

Advanced Research Institute /ID# 164784

Ogden, Utah, United States

Site Status

Duplicate_Care Access Research /ID# 164794

Salt Lake City, Utah, United States

Site Status

Velocity Clinical Research - Salt Lake City /ID# 166076

West Jordan, Utah, United States

Site Status

Washington Gastroenterology /ID# 164824

Bellevue, Washington, United States

Site Status

Virginia Mason Medical Center /ID# 164913

Seattle, Washington, United States

Site Status

The Vancouver Clinic, INC. PS /ID# 164918

Vancouver, Washington, United States

Site Status

Allegiance Research Specialists /ID# 165346

Wauwatosa, Wisconsin, United States

Site Status

Cardio Alem /ID# 211285

San Isidro, Buenos Aires, Argentina

Site Status

Hospital Italiano de Buenos Aires /ID# 215541

Ciudad Autonoma Buenos Aires, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Gedyt /ID# 210020

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Cemic /Id# 169182

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Hospital Provincial del Centenario /ID# 171252

Rosario, Santa Fe Province, Argentina

Site Status

Hospital Privado Univesitario /ID# 169230

Córdoba, , Argentina

Site Status

Concord Repatriation General Hospital /ID# 171512

Concord, New South Wales, Australia

Site Status

Coral Sea Clinical Research institute /ID# 212988

North Mackay, Queensland, Australia

Site Status

Mater Misericordiae Limited /ID# 204909

South Brisbane, Queensland, Australia

Site Status

Royal Adelaide Hospital /ID# 171514

Adelaide, South Australia, Australia

Site Status

Box Hill Hospital /ID# 203736

Box Hill, Victoria, Australia

Site Status

Fiona Stanley Hospital /ID# 171513

Murdoch, Western Australia, Australia

Site Status

Medizinische Universitaet Wien /ID# 169465

Vienna, Vienna, Austria

Site Status

Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 214470

Salzburg, , Austria

Site Status

UCL Saint-Luc /ID# 200303

Woluwe-Saint-Lambert, Brussels Capital, Belgium

Site Status

CHU de Liege Sart Tilman /ID# 217534

Liège, Liege, Belgium

Site Status

AZ Sint-Lucas /ID# 200302

Ghent, , Belgium

Site Status

University Clinical Centre of the Republic of Srpska /ID# 208051

Banja Luka, Republika Srpska, Bosnia and Herzegovina

Site Status

University Clinical Center Tuzla /ID# 210325

Tuzla, Tuzlanski, Bosnia and Herzegovina

Site Status

Clinical Center University of Sarajevo /ID# 203887

Sarajevo, , Bosnia and Herzegovina

Site Status

Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217842

Sarajevo, , Bosnia and Herzegovina

Site Status

Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166852

Goiânia, Goiás, Brazil

Site Status

Hospital Nossa Senhora das Graças /ID# 166863

Curitiba, Paraná, Brazil

Site Status

Hospital de Clinicas de Porto Alegre /ID# 166862

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Upeclin Fmb - Unesp /Id# 166867

Botucatu, São Paulo, Brazil

Site Status

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 166866

Ribeirão Preto, São Paulo, Brazil

Site Status

Faculdade de Medicina do ABC /ID# 208323

Santo André, São Paulo, Brazil

Site Status

Kaiser Clinica e Hospital Dia /ID# 166865

São José do Rio Preto, São Paulo, Brazil

Site Status

UMHAT Kaspela EOOD /ID# 167613

Plovdiv, , Bulgaria

Site Status

Duplicate_Second MHAT Sofia /ID# 167614

Sofia, , Bulgaria

Site Status

MHAT Trakia /ID# 201679

Stara Zagora, , Bulgaria

Site Status

University of Calgary /ID# 166974

Calgary, Alberta, Canada

Site Status

Allen Whey Khye Lim Professional Corporation /ID# 168044

Edmonton, Alberta, Canada

Site Status

University of Alberta - Zeidler Ledcor Centre /ID# 166971

Edmonton, Alberta, Canada

Site Status

South Edmonton Gastroenterology Research Clinic /ID# 166978

Edmonton, Alberta, Canada

Site Status

Fraser Clinical Trials Inc /ID# 166968

New Westminster, British Columbia, Canada

Site Status

GIRI Gastrointestinal Research Institute /ID# 166975

Vancouver, British Columbia, Canada

Site Status

QEII - Health Sciences Centre /ID# 169307

Halifax, Nova Scotia, Canada

Site Status

Medicor Research Inc /ID# 166979

Greater Sudbury, Ontario, Canada

Site Status

London Health Sciences Center /ID# 221038

London, Ontario, Canada

Site Status

Scott Shulman Medicine Professional Corporation /ID# 169066

North Bay, Ontario, Canada

Site Status

Taunton Surgical Centre /ID# 168043

Oshawa, Ontario, Canada

Site Status

Ottawa Hospital Research Institute /ID# 212414

Ottawa, Ontario, Canada

Site Status

Toronto Digestive Disease Asso /ID# 166972

Vaughan, Ontario, Canada

Site Status

CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 166969

Lévis, Quebec, Canada

Site Status

Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170120

Montreal, Quebec, Canada

Site Status

Royal Victoria Hospital / McGill University Health Centre /ID# 170119

Montreal, Quebec, Canada

Site Status

CIUSSS de l'Estrie - CHUS /ID# 170940

Sherbrooke, Quebec, Canada

Site Status

M y F Estudios Clínicos /ID# 169984

Santiago, Region Metropolitana Santiago, Chile

Site Status

Research Group /ID# 203179

Santiago, Santiago Metropolitan, Chile

Site Status

Hospital Guillermo Grant Benavente de Concepción /ID# 212423

Concepción, , Chile

Site Status

CTR Estudios Clinicos /ID# 203941

Providencia, , Chile

Site Status

Hospital Clinico Universidad De Los Andes /ID# 207466

Santiago, , Chile

Site Status

Zhongshan Hospital Xiamen University /ID# 204984

Xiamen, Fujian, China

Site Status

The First Affiliated Hospital, Sun Yat-sen University /ID# 205228

Guangzhou, Guangdong, China

Site Status

Nanfang Hospital of Southern Medical University /ID# 204083

Guangzhou, Guangdong, China

Site Status

The Sixth Affiliated Hosp Sun /ID# 204077

Guangzhou, Guangdong, China

Site Status

Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204081

Wuhan, Hubei, China

Site Status

Nanjing Drum Tower Hospital /ID# 204900

Nanjing, Jiangsu, China

Site Status

The First Affiliated Hospital of Nanchang University /ID# 204092

Nanchang, Jiangxi, China

Site Status

The First Hospital of Jilin University /ID# 206868

Changchun, Jilin, China

Site Status

Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204091

Shanghai, Shanghai Municipality, China

Site Status

The second Affiliated hospital of Zhejiang University school of Medicine /ID# 204073

Hangzhou, Zhejiang, China

Site Status

Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204076

Hangzhou, Zhejiang, China

Site Status

Beijing Friendship Hospital /ID# 204173

Beijing, , China

Site Status

The Second Xiangya Hospital of Central South University /ID# 204082

Changsha, , China

Site Status

Duplicate_Tianjin Med Univ General Hosp /ID# 206994

Tianjin, , China

Site Status

Tongji Hospital Tongji Medical College of HUST /ID# 204088

Wuhan, , China

Site Status

Hospital Pablo Tobon Uribe /ID# 202404

Medellín, Antioquia, Colombia

Site Status

Hospital Universitario San Vic /ID# 200029

Medellín, , Colombia

Site Status

Clinical Hospital Dubrava /ID# 171185

Zagreb, City of Zagreb, Croatia

Site Status

Klinicki bolnicki centar Sestre milosrdnice /ID# 205535

Zagreb, City of Zagreb, Croatia

Site Status

Klinicki bolnicki centar Zagreb /ID# 171203

Zagreb, City of Zagreb, Croatia

Site Status

Poliklinika Solmed /ID# 211519

Zagreb, City of Zagreb, Croatia

Site Status

UHC Split /ID# 171191

Split, , Croatia

Site Status

Zadar General Hospital /ID# 205536

Zadar, , Croatia

Site Status

Nemocnice Ceske Budejovice a.s. /ID# 224389

České Budějovice, , Czechia

Site Status

Hepato-Gastroenterologie HK, s.r.o. /ID# 171401

Hradec Králové, , Czechia

Site Status

ARTROSCAN s.r.o. /ID# 200790

Ostrava, , Czechia

Site Status

ResTrial s.r.o. /ID# 208653

Prague, , Czechia

Site Status

Herlev Hospital /ID# 202423

Herlev, Capital Region, Denmark

Site Status

Nordsjaellands Hospital /ID# 202424

Hilleroed, Capital Region, Denmark

Site Status

Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 202425

Hvidovre, Capital Region, Denmark

Site Status

Duplicate_Sjaellands Universitets Hospital /ID# 209445

Roskilde, Region Sjælland, Denmark

Site Status

Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171012

Alexandria, , Egypt

Site Status

Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171013

Alexandria, , Egypt

Site Status

Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209564

Alexandria, , Egypt

Site Status

National Hepatology and Tropical Medicine Research Institute /ID# 170989

Cairo, , Egypt

Site Status

Air Force Specialized Hospital /ID# 170996

Cairo, , Egypt

Site Status

National Liver Institute /ID# 170988

Menoufiya, , Egypt

Site Status

West Tallinn Central Hospital /ID# 202785

Tallinn, , Estonia

Site Status

CHU Grenoble - Hopital Michallon /ID# 219034

La Tronche, , France

Site Status

Clinique Jules Verne /ID# 219073

Nantes, , France

Site Status

CH Valenciennes /ID# 219035

Valenciennes, , France

Site Status

Universitatsklinikum Mannheim /ID# 168759

Mannheim, Baden-Wurttemberg, Germany

Site Status

Universitaetsklinikum Ulm /ID# 203560

Ulm, Baden-Wurttemberg, Germany

Site Status

Universitaetsklinikum Erlangen /ID# 203552

Erlangen, Bavaria, Germany

Site Status

Universitaetsklinikum Frankfurt /ID# 203566

Frankfurt am Main, Hesse, Germany

Site Status

Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206741

Saarbrücken, Saarland, Germany

Site Status

Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168757

Kiel, Schleswig-Holstein, Germany

Site Status

Gastroenterologie am Mexikoplatz /ID# 203575

Berlin, , Germany

Site Status

Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203570

Essen, , Germany

Site Status

Agaplesion Markus Krankenhaus /ID# 168758

Frankfurt am Main, , Germany

Site Status

Universitaetsklinikum Halle (Saale) /ID# 207455

Halle, , Germany

Site Status

Medizinisches Versorgungszentrum Portal 10 /ID# 200214

Münster, , Germany

Site Status

General Hospital of Athens Ippokratio /ID# 167045

Athens, Attica, Greece

Site Status

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202104

Athens, Attica, Greece

Site Status

Tzaneio general hospital of Piraeus /ID# 206433

Piraeus, Attica, Greece

Site Status

University General Hospital of Heraklion PA.G.N.I /ID# 167044

Heraklion, Crete, Greece

Site Status

General Hospital of Thessaloniki Hippokrateio /ID# 208825

Thessaloniki, , Greece

Site Status

Tuen Mun Hospital /ID# 171218

Hong Kong, , Hong Kong

Site Status

Mohacsi Korhaz /ID# 209441

Mohács, Baranya, Hungary

Site Status

CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205547

Encs, Borsod-Abauj Zemplen county, Hungary

Site Status

Debreceni Egyetem Klinikai Kozpont /ID# 216419

Debrecen, Hajdú-Bihar, Hungary

Site Status

Bugat Pal Korhaz /ID# 201893

Gyöngyös, Heves County, Hungary

Site Status

Szent Borbala Korhaz /ID# 209897

Tatabánya, Komárom-Esztergom, Hungary

Site Status

Obudai Egeszsegugyi Centrum Kft. /ID# 201892

Budapest, Pest County, Hungary

Site Status

Semmelweis Egyetem /ID# 210167

Budapest, , Hungary

Site Status

Magyar Honvedseg Egeszsegugyi Kozpont /ID# 201724

Budapest, , Hungary

Site Status

Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 201723

Debrecen, , Hungary

Site Status

Pest Megyei Flor Ferenc Korhaz /ID# 206154

Kistarcsa, , Hungary

Site Status

Mentahaz Maganorvosi Kozpont /ID# 201895

Székesfehérvár, , Hungary

Site Status

Mercy University Hospital /ID# 206511

Cork, , Ireland

Site Status

Soroka University Medical Center /ID# 169913

Beersheba, Southern District, Israel

Site Status

Tel Aviv Sourasky Medical Center /ID# 204877

Tel Aviv, Tel Aviv, Israel

Site Status

Assaf Harofeh Medical Center /ID# 204872

Be’er Ya‘aqov, , Israel

Site Status

Hadassah Medical Center-Hebrew University /ID# 169928

Jerusalem, , Israel

Site Status

Rabin Medical Center /ID# 202636

Petah Tikva, , Israel

Site Status

Kaplan Medical Center /ID# 170276

Rehovot, , Israel

Site Status

Policlinico Universitario Campus Bio-Medico /ID# 168183

Rome, Lazio, Italy

Site Status

Azienda Ospedaliera San Camillo Forlanini /ID# 168184

Rome, Lazio, Italy

Site Status

Istituto Clinico Humanitas /ID# 168185

Rozzano, Milano, Italy

Site Status

Fondazione PTV Policlinico Tor Vergata /ID# 168188

Rome, Roma, Italy

Site Status

Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 168182

Rome, Roma, Italy

Site Status

IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168186

Negrar, Verona, Italy

Site Status

IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 168187

Bologna, , Italy

Site Status

A.O. Per L'Emergenza Cannizzaro /ID# 168190

Catania, , Italy

Site Status

Policlinico San Martino/Univer /ID# 168191

Genova, , Italy

Site Status

ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168181

Milan, , Italy

Site Status

ASST Grande Ospedale Metropolitano Niguarda /ID# 170849

Milan, , Italy

Site Status

Azienda Ospedaliero-Universitaria di Modena /ID# 201897

Modena, , Italy

Site Status

A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 168189

Palermo, , Italy

Site Status

Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202421

Pisa, , Italy

Site Status

Aichi Medical University Hospital /ID# 165971

Nagakute-shi, Aichi-ken, Japan

Site Status

Nagoya University Hospital /ID# 165969

Nagoya, Aichi-ken, Japan

Site Status

Nagoya City University Hospital /ID# 165970

Nagoya, Aichi-ken, Japan

Site Status

Toyohashi Municipal Hospital /ID# 200175

Toyohashi, Aichi-ken, Japan

Site Status

National Hospital Organization Hirosaki General Medical Center /ID# 165961

Hirosaki-shi, Aomori, Japan

Site Status

Toho University Sakura Medical Center /ID# 165963

Sakura-shi, Chiba, Japan

Site Status

Fukuoka University Chikushi Hospital /ID# 214404

Chikushino-shi, Fukuoka, Japan

Site Status

Kurume University Hospital /ID# 166012

Kurume-shi, Fukuoka, Japan

Site Status

National Hospital Organization Takasaki General Medical Center /ID# 167127

Takasaki-shi, Gunma, Japan

Site Status

NHO Fukuyama Medical Center /ID# 167131

Fukuyama-shi, Hiroshima, Japan

Site Status

Hiroshima University Hospital /ID# 166014

Hiroshima, Hiroshima, Japan

Site Status

Asahikawa Medical University Hospital /ID# 167120

Asahikawa-shi, Hokkaido, Japan

Site Status

Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165960

Sapporo, Hokkaido, Japan

Site Status

Sapporo Medical University Hospital /ID# 167124

Sapporo, Hokkaido, Japan

Site Status

Sapporo IBD Clinic /ID# 223561

Sapporo, Hokkaido, Japan

Site Status

Aoyama Clinic /ID# 166009

Kobe, Hyōgo, Japan

Site Status

Hyogo College of Medicine College Hospital /Id# 165973

Nishinomiya-shi, Hyōgo, Japan

Site Status

Kanazawa University Hospital /ID# 169218

Kanazawa, Ishikawa-ken, Japan

Site Status

Iwate Medical University Uchimaru Medical Center /ID# 202464

Morioka, Iwate, Japan

Site Status

Imamura General Hospital /ID# 227137

Kagoshima, Kagoshima-ken, Japan

Site Status

Idzuro Imamura Hospital /ID# 206654

Kagoshima, Kagoshima-ken, Japan

Site Status

Sameshima Hospital /ID# 206675

Kagoshima, Kagoshima-ken, Japan

Site Status

Yokohama City University Medical Center /ID# 167128

Yokohama, Kanagawa, Japan

Site Status

Japanese Red Cross Kyoto Daiichi Hosital /ID# 165972

Kyoto, Kyoto, Japan

Site Status

Kyoto University Hospital /ID# 169889

Kyoto, Kyoto, Japan

Site Status

Yokkaichi Hazu Medical Center /ID# 167196

Yokkaichi-shi, Mie-ken, Japan

Site Status

Tohoku University Hospital /ID# 167122

Sendai, Miyagi, Japan

Site Status

Nara Medical University Hospital /ID# 169219

Kashihara-shi, Nara, Japan

Site Status

Kenseikai Dongo Hospital /ID# 208104

Yamatotakada-shi, Nara, Japan

Site Status

Niigata University Medical & Dental Hospital /ID# 170045

Niigata, Niigata, Japan

Site Status

Ishida Clinic of IBD and Gastroenterology /ID# 167121

Ōita, Oita Prefecture, Japan

Site Status

Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 166010

Kurashiki-shi, Okayama-ken, Japan

Site Status

Okayama University Hospital /ID# 167356

Okayama, Okayama-ken, Japan

Site Status

Kinshukai Infusion Clinic /ID# 218872

Osaka, Osaka, Japan

Site Status

Osaka Metropolitan University Hospital /ID# 166015

Osaka, Osaka, Japan

Site Status

Osaka University Hospital /ID# 169663

Suita-shi, Osaka, Japan

Site Status

Osaka Medical and Pharmaceutical University Hospital /ID# 206326

Takatsuki-shi, Osaka, Japan

Site Status

Tokitokai Tokito clinic /ID# 165962

Saitama-shi, Saitama, Japan

Site Status

Shiga University of Medical Science Hospital /ID# 167129

Ōtsu, Shiga, Japan

Site Status

Hamamatsu University Hospital /ID# 224352

Hamamatsu, Shizuoka, Japan

Site Status

NHO Shizuoka Medical Center /ID# 167125

Sunto-gun, Shizuoka, Japan

Site Status

Tokyo Medical And Dental University Hospital /ID# 165965

Bunkyo-ku, Tokyo, Japan

Site Status

Tokai University Hachioji Hospital /ID# 165967

Hachioji-shi, Tokyo, Japan

Site Status

The Jikei University Hospital /ID# 167130

Minato-ku, Tokyo, Japan

Site Status

Kyorin University Hospital /ID# 165966

Mitaka-shi, Tokyo, Japan

Site Status

Tokyo Women's Medical University Hospital /ID# 205980

Shinjuku-ku, Tokyo, Japan

Site Status

Toyama Prefectural Central Hospital /ID# 217834

Toyama, Toyama, Japan

Site Status

Japanese Red Cross Wakayama Medical Center /ID# 200643

Wakayama, Wakayama, Japan

Site Status

Wakayama Medical University Hospital /ID# 169482

Wakayama, Wakayama, Japan

Site Status

Yamagata University Hospital /ID# 200157

Yamagata, Yamagata, Japan

Site Status

VCA Polyclinic Aura /ID# 169498

Riga, , Latvia

Site Status

Pauls Stradins Clinical University Hospital /ID# 169519

Riga, , Latvia

Site Status

Digestive Disease Center Gastro /ID# 169508

Riga, , Latvia

Site Status

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 206936

Kaunas, , Lithuania

Site Status

Vilnius University Hospital Santaros Klinikos /ID# 203286

Vilnius, , Lithuania

Site Status

Hospital Sultanah Bahiyah /ID# 202626

Alor Star, Kedah, Malaysia

Site Status

Universiti Sains Malaysia /ID# 200102

Kelantan, Kelantan, Malaysia

Site Status

Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170773

Kuala Lumpur, Selangor, Malaysia

Site Status

Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207579

Durango, Durango, Mexico

Site Status

Morales Vargas Centro de Investigacion S.C. /ID# 203494

León, Guanajuato, Mexico

Site Status

Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 207238

Guadalajara, Jalisco, Mexico

Site Status

Radboud Universitair Medisch Centrum /ID# 166928

Nijmegen, Gelderland, Netherlands

Site Status

Zuyderland Medisch Centrum /ID# 169700

Heerlen, Limburg, Netherlands

Site Status

Onze Lieve Vrouwe Gasthuis /ID# 166929

Amsterdam, , Netherlands

Site Status

Academisch Medisch Centrum /ID# 166927

Amsterdam, , Netherlands

Site Status

Medisch Spectrum Twente /ID# 170298

Enschede, , Netherlands

Site Status

Malopolskie Centrum Kliniczne /ID# 202167

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Vistamed /ID# 208572

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Centrum Zdrowia MDM /ID# 200491

Warsaw, Masovian Voivodeship, Poland

Site Status

WIP Warsaw IBD Point Profesor Kierkus /ID# 224301

Warsaw, Masovian Voivodeship, Poland

Site Status

Centrum Medyczne Reuma Park /ID# 200490

Warsaw, Masovian Voivodeship, Poland

Site Status

Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170245

Guimarães, Braga District, Portugal

Site Status

Hospital Egas Moniz /ID# 170253

Lisbon, Porto District, Portugal

Site Status

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200607

Ponte de Lima, Viana do Castelo District, Portugal

Site Status

Hospital Garcia de Orta, EPE /ID# 170241

Almada, , Portugal

Site Status

Centro Hospitalar Universitario de Sao Joao, EPE /ID# 170248

Porto, , Portugal

Site Status

Mindful Medical Research /ID# 203358

San Juan, , Puerto Rico

Site Status

School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166771

San Juan, , Puerto Rico

Site Status

Institutul Clinic Fundeni /ID# 167817

Sector 2, București, Romania

Site Status

Clinica GASTRO MED SRL /ID# 206369

Cluj-Napoca, Cluj, Romania

Site Status

Cabinet Particular Policlinic Algomed /ID# 167818

Timișoara, , Romania

Site Status

Immanuel Kant Baltic Federal University /ID# 203811

Kaliningrad, Kaliningrad Oblast, Russia

Site Status

LLC Medical Center /ID# 209236

Novosibirsk, Novosibirsk Oblast, Russia

Site Status

Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202990

Perm, Permskiy Kray, Russia

Site Status

LLC Novaya Klinika /ID# 206616

Pyatigorsk, Stavropol Kray, Russia

Site Status

Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202997

Stavropol, Stavropol Kray, Russia

Site Status

Kazan State Medical University /ID# 169638

Kazan', Tatarstan, Respublika, Russia

Site Status

Olla-Med Clinic /ID# 208720

Moscow, , Russia

Site Status

P.A. Bayandin Murmansk Regiona /ID# 169639

Murmansk, , Russia

Site Status

Republican hospital named after V.A. Baranov /ID# 206488

Petrozavodsk, , Russia

Site Status

Euromedservice /ID# 206610

Pushkin, , Russia

Site Status

X7 Clinical Research Center /ID# 216350

Saint Petersburg, , Russia

Site Status

City Clinical Hospital No. 31 /ID# 208868

Saint Petersburg, , Russia

Site Status

Clinical Hosp Center Zvezdara /ID# 168214

Belgrade, Beograd, Serbia

Site Status

Military Medical Academy /ID# 168783

Belgrade, Beograd, Serbia

Site Status

University Clinical Center Serbia /ID# 168215

Belgrade, Beograd, Serbia

Site Status

Clin Hosp Ctr Bezanijska Kosa /ID# 168750

Belgrade, Beograd, Serbia

Site Status

University Clinical Center Kragujevac /ID# 205859

Kragujevac, Sumadijski Okrug, Serbia

Site Status

Clinical Center Vojvodina /ID# 168213

Novi Sad, Vojvodina, Serbia

Site Status

KL Ling Gastroenterology and Liver Clinic /ID# 217962

Singapore, , Singapore

Site Status

Gleneagles Medical Centre /ID# 206531

Singapore, , Singapore

Site Status

Tan Tock Seng Hospital /ID# 203160

Singapore, , Singapore

Site Status

Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169958

Banská Bystrica, , Slovakia

Site Status

KM Management, spol. s.r.o. /ID# 170201

Nitra, , Slovakia

Site Status

Univ Medical Ctr Ljubljana /ID# 217795

Ljubljana, , Slovenia

Site Status

Farmovs (Pty) Ltd /Id# 207535

Bloemfontein, Free State, South Africa

Site Status

Lenasia Clinical Trial Centre /ID# 205145

Johannesburg, Gauteng, South Africa

Site Status

Wits Clinical Research Site /ID# 170852

Johannesburg, Gauteng, South Africa

Site Status

Allergy & Immunology (AIU) /ID# 171431

Cape Town, Western Cape, South Africa

Site Status

Dr JP Wright /ID# 170887

Cape Town, Western Cape, South Africa

Site Status

Private Practice Dr MN Rajabally /ID# 169853

Cape Town, Western Cape, South Africa

Site Status

Hayang University GuriHospital /ID# 167587

Guri-si, Gyeonggido, South Korea

Site Status

CHA University Bundang Medical Center /ID# 167592

Seongnam-si, Gyeonggido, South Korea

Site Status

Kangbuk Samsung Hospital /ID# 167586

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Yonsei University Health System Severance Hospital /ID# 167590

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Inje University Haeundae Hospital /ID# 202630

Busan, , South Korea

Site Status

Dong-A University Hospital /ID# 167591

Busan, , South Korea

Site Status

Pusan National University Hospital /ID# 167589

Busan, , South Korea

Site Status

Kyungpook National University Hospital /ID# 207019

Daegu, , South Korea

Site Status

Samsung Medical Center /ID# 167588

Seoul, , South Korea

Site Status

Chung-Ang University Hostipal /ID# 207018

Seoul, , South Korea

Site Status

Hospital Universitari Son Espases /ID# 201998

Palma de Mallorca, Balearic Islands, Spain

Site Status

Hospital Universitario de Navarra /ID# 202355

Pamplona, Navarre, Spain

Site Status

Hospital Universitario A Coruna - CHUAC /ID# 203910

A Coruña, , Spain

Site Status

Hospital Clinic de Barcelona /ID# 201990

Barcelona, , Spain

Site Status

Hospital Universitario de Girona Doctor Josep Trueta /ID# 202645

Girona, , Spain

Site Status

Hospital Juan Ramon Jimenez /ID# 201995

Huelva, , Spain

Site Status

Hospital Universitario La Paz /ID# 201994

Madrid, , Spain

Site Status

Hospital Universitario de Salamanca /ID# 206358

Salamanca, , Spain

Site Status

Hospital Universitario Virgen Macarena /ID# 201993

Seville, , Spain

Site Status

Hospital Clinico Universitario de Valencia /ID# 209657

Valencia, , Spain

Site Status

Hospital Universitario y Politecnico La Fe /ID# 201992

Valencia, , Spain

Site Status

Hallands Hospital Halmstad /ID# 170828

Halmstad, Halland County, Sweden

Site Status

Karolinska University Hospital Solna /ID# 224488

Solna, Stockholm County, Sweden

Site Status

Alingsas lasarett /ID# 170826

Alingsås, Västra Götaland County, Sweden

Site Status

Sodra Alvsborgs sjukhus /ID# 203077

Borås, Västra Götaland County, Sweden

Site Status

Sahlgrenska University Hospital /ID# 169171

Gothenburg, Västra Götaland County, Sweden

Site Status

Universitätsspital Zürich /ID# 170998

Zurich, Canton of Zurich, Switzerland

Site Status

Inselspital, Universitätsspital Bern /ID# 170997

Bern, , Switzerland

Site Status

China Medical University Hospital /ID# 169791

Taichung, , Taiwan

Site Status

Taichung Veterans General Hospital /ID# 169790

Taichung, , Taiwan

Site Status

National Taiwan University Hospital /ID# 169792

Taipei, , Taiwan

Site Status

Acibadem Kozyatagi Hospital /ID# 209406

Kadıköy, Istanbul, Turkey (Türkiye)

Site Status

Erciyes University Medical Fac /ID# 171331

Melikgazi, Kayseri, Turkey (Türkiye)

Site Status

Ankara Univ Medical Faculty /ID# 206409

Ankara, , Turkey (Türkiye)

Site Status

Inonu Universitesi Turgut Ozal /ID# 201268

Battalgazi/malatya, , Turkey (Türkiye)

Site Status

Mustafa Kemal University Medic /ID# 171336

Hatay, , Turkey (Türkiye)

Site Status

Istanbul University Istanbul Medical Faculty /ID# 171364

Istanbul, , Turkey (Türkiye)

Site Status

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171332

Istanbul, , Turkey (Türkiye)

Site Status

Mersin University Medical /ID# 171338

Mersin, , Turkey (Türkiye)

Site Status

Sisli Etfal Train & Res Hosp /ID# 171334

Şişli, , Turkey (Türkiye)

Site Status

Gazi Universitesi Tip Fakultes /ID# 217444

Yenimahalle, , Turkey (Türkiye)

Site Status

Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203738

Kyiv, Kyivska Oblast, Ukraine

Site Status

Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167907

Kharkiv, , Ukraine

Site Status

Kyiv Municipal Clinical Hospital #18 /ID# 207889

Kyiv, , Ukraine

Site Status

MNI KRC Kyiv Regional Clinical Hospital /ID# 202454

Kyiv, , Ukraine

Site Status

Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167908

Lviv, , Ukraine

Site Status

CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 222110

Vinnytsia, , Ukraine

Site Status

South Eastern Health and Social Care Trust /ID# 205323

Belfast, Antrim, United Kingdom

Site Status

Warrington and Halton Hospitals NHS Foundation Trust /ID# 171383

Warrington, Cheshire West And Chester, United Kingdom

Site Status

Warrington and Halton Hospitals NHS Foundation Trust /ID# 209086

Warrington, Cheshire West And Chester, United Kingdom

Site Status

Royal United Hospitals Bath /ID# 169074

Bath, , United Kingdom

Site Status

University Hospitals Birmingham NHS Foundation Trust /ID# 169070

Birmingham, , United Kingdom

Site Status

The Dudley Group NHS Foundation Trust /ID# 169069

Dudley, , United Kingdom

Site Status

King's College Hospital NHS Foundation Trust /ID# 169072

London, , United Kingdom

Site Status

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169075

Newcastle upon Tyne, , United Kingdom

Site Status

Stockport NHS foundation trust /ID# 208719

Stockport, , United Kingdom

Site Status

Taunton and Somerset NHS Foundation Trust /ID# 209665

Taunton, , United Kingdom

Site Status

St George's University Hospitals NHS Foundation Trust /ID# 205552

Tooting, , United Kingdom

Site Status

The Royal Wolverhampton NHS Trust /ID# 171382

Wolverhampton, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Australia Austria Belgium Bosnia and Herzegovina Brazil Bulgaria Canada Chile China Colombia Croatia Czechia Denmark Egypt Estonia France Germany Greece Hong Kong Hungary Ireland Israel Italy Japan Latvia Lithuania Malaysia Mexico Netherlands Poland Portugal Puerto Rico Romania Russia Serbia Singapore Slovakia Slovenia South Africa South Korea Spain Sweden Switzerland Taiwan Turkey (Türkiye) Ukraine United Kingdom

References

Explore related publications, articles, or registry entries linked to this study.

Panes J, Louis E, Bossuyt P, Joshi N, Lee WJ, Lacerda AP, Kligys K, Xuan S, Shukla N, Loftus EV Jr. Induction of Endoscopic Response, Remission, and Ulcer-Free Endoscopy With Upadacitinib Is Associated With Improved Clinical Outcomes and Quality of Life in Patients With Crohn's Disease. Inflamm Bowel Dis. 2025 Feb 6;31(2):394-403. doi: 10.1093/ibd/izae200.

Reference Type DERIVED
PMID: 39231444 (View on PubMed)

Ghosh S, Feagan BG, Parra RS, Lopes S, Steinlauf A, Kakuta Y, Joshi N, Lee WJ, Lacerda AP, Zhou Q, Xuan S, Kligys K, Shukla N, Louis E. Impact of Upadacitinib Induction and Maintenance Therapy on Health-related Quality of Life, Fatigue, and Work Productivity in Patients with Moderately-to-severely Active Crohn's Disease. J Crohns Colitis. 2024 Nov 4;18(11):1804-1818. doi: 10.1093/ecco-jcc/jjae083.

Reference Type DERIVED
PMID: 38835235 (View on PubMed)

Peyrin-Biroulet L, Panaccione R, Louis E, Atreya R, Rubin DT, Lindsay JO, Siffledeen J, Lukin DJ, Wright J, Watanabe K, Ford S, Remple VP, Lacerda AP, Dubcenco E, Garrison A, Zhou Q, Berg S, Anyanwu SI, Schreiber S. Upadacitinib Achieves Clinical and Endoscopic Outcomes in Crohn's Disease Regardless of Prior Biologic Exposure. Clin Gastroenterol Hepatol. 2024 Oct;22(10):2096-2106. doi: 10.1016/j.cgh.2024.02.026. Epub 2024 Mar 15.

Reference Type DERIVED
PMID: 38492904 (View on PubMed)

Colombel JF, Hisamatsu T, Atreya R, Bresso F, Thin L, Panaccione R, Parra RS, Ford S, Remple VP, Lacerda AP, Anyanwu SI, Mallick M, Garrison A, Regueiro M. Upadacitinib Reduces Crohn's Disease Symptoms Within the First Week of Induction Therapy. Clin Gastroenterol Hepatol. 2024 Aug;22(8):1668-1677. doi: 10.1016/j.cgh.2024.02.027. Epub 2024 Mar 15.

Reference Type DERIVED
PMID: 38492903 (View on PubMed)

Loftus EV Jr, Panes J, Lacerda AP, Peyrin-Biroulet L, D'Haens G, Panaccione R, Reinisch W, Louis E, Chen M, Nakase H, Begun J, Boland BS, Phillips C, Mohamed MF, Liu J, Geng Z, Feng T, Dubcenco E, Colombel JF. Upadacitinib Induction and Maintenance Therapy for Crohn's Disease. N Engl J Med. 2023 May 25;388(21):1966-1980. doi: 10.1056/NEJMoa2212728.

Reference Type DERIVED
PMID: 37224198 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

Access external resources that provide additional context or updates about the study.

https://www.rxabbvie.com

This clinical study may be evaluating a usage that is not currently FDA approved. Please see US Prescribing Information for approved uses.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2017-001240-35

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

M14-433

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.