Causes and Mechanisms of Space Hemolysis At High Altitudes

NCT ID: NCT05496309

Last Updated: 2025-03-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 8 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-05-02
• Study Completion Date: 2024-09-15

Brief Summary

Anemia is a lack of red blood cells (RBCs) in the circulation. Because RBCs carry the oxygen your body needs to function, anemia can affect one's ability to stay awake, alert, and perform physical activities. Anemia may happen for several reasons, including increased RBC destruction. Anemia often occurs in people who have been in bed for long periods (e.g., if they are very sick) or have decreased mobility (anemia of immobility). Interestingly, astronauts who have left Earth and traveled in space also return anemic. In fact, 5 decades of NASA data showed that astronauts' anemia was more severe the longer they were in space. In another study, astronauts aboard the International Space Station were shown to destroy 54% more of their RBCs in space. RBC destruction may be the culprit of space anemia as well as anemia of immobility on Earth. The ANEMIA Study proposes to measure key aspects of RBC destruction in astronauts in space. These measures will test critical hypotheses on the effects of spaceflight on red blood cells.

Conditions

Anemia; Weightlessness

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Group

The group is a cohort of 4 persons.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Astronauts selected to fly on a space mission.

Exclusion Criteria

• Astronauts not selected to fly on a space mission.

• Minimum Eligible Age: 24 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ottawa Hospital Research Institute

OTHER

Sponsor Role: lead

Responsible Party

Dr. Guy Trudel

Professor of Medicine, Surgery and Biochemistry

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Guy Trudel

Role: PRINCIPAL_INVESTIGATOR

Ottawa Hospital Research Institute

Locations

Ottawa Hospital Research Institute

Ottawa, Ontario, Canada

Countries

Canada

Other Identifiers

0220470-01H

Identifier Type: -

Identifier Source: org_study_id