Electrical Brain Stimulation and Pharmacological Treatments in Autism Spectrum Disorder

NCT ID: NCT05491720

Last Updated: 2023-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-15

Study Completion Date

2022-08-03

Brief Summary

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This project aims to comparing the effectiveness of transcranial direct current stimulation with common pharmacological treatments on behavioral problems and cognitive deficits of children with autism spectrum disorder

Detailed Description

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45 children with autism spectrum disorder are recruited in Fatemi Hospital at Ardabil University of Medical Sciences. The patients will be randomized into 3 Intervention groups of 15 with tDCS stimulation, risperidone, and placebo medication as the interventions. The study will be a randomized double-blind controlled design. The experimenter and the patient are blinded and are not aware of the study. Intervention group 1: TDCS intervention protocol consists of 10 sessions of 20 minutes of 1.5 mA electrical stimulation on consecutive days. Anodal electrode will be placed over the F3 and cathodal electrode will be placed over the Fp2. They will also receive a placebo tablet (Galenus pharmaceutical company) in each stimulation session. Intervention group 2: Participants in this group will receive two daily Risperidone 1 mg tablets (Sobhan Pharmaceutical Company) for 10 consecutive days. Intervention group 3: Participants in this group undergo 10 daily sessions of sham tDCS concurrent with a placebo tablet (Galenus pharmaceutical company) for 10 consecutive days.

Conditions

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Autism Spectrum Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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tDCS group

TDCS intervention protocol consists of 10 sessions of 20 minutes of 1.5 mA electrical stimulation on consecutive days. Anodal electrode will be placed over the left dorsolateral prefrontal cortex and cathodal electrode will be placed over the right supraorbital area.

Group Type EXPERIMENTAL

transcranial direct current stimulation

Intervention Type DEVICE

Patients will receive 10 sessions of 20 minutes of 1.5 mA electrical stimulation on consecutive days

Placebo

Intervention Type DRUG

Patients will receive placebo tablet (Galenus pharmaceutical company)

Medication group

Participants in this group will receive two daily Risperidone 1 mg tablets (Sobhan Pharmaceutical Company) for 10 consecutive days

Group Type EXPERIMENTAL

RisperiDONE 1 MG/ML

Intervention Type DRUG

Patients will receive two daily Risperidone 1 mg tablets (Sobhan Pharmaceutical Company) for 10 consecutive days

sham transcranial direct current stimulation

Intervention Type DEVICE

Patients will receive 10 sessions of 20 minutes of sham electrical stimulation on consecutive days

Control group

Participants in this group undergo 10 daily sessions of sham tDCS concurrent with placebo tablets ( Galenus pharmaceutical company) for 10 consecutive days.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Patients will receive placebo tablet (Galenus pharmaceutical company)

sham transcranial direct current stimulation

Intervention Type DEVICE

Patients will receive 10 sessions of 20 minutes of sham electrical stimulation on consecutive days

Interventions

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RisperiDONE 1 MG/ML

Patients will receive two daily Risperidone 1 mg tablets (Sobhan Pharmaceutical Company) for 10 consecutive days

Intervention Type DRUG

transcranial direct current stimulation

Patients will receive 10 sessions of 20 minutes of 1.5 mA electrical stimulation on consecutive days

Intervention Type DEVICE

Placebo

Patients will receive placebo tablet (Galenus pharmaceutical company)

Intervention Type DRUG

sham transcranial direct current stimulation

Patients will receive 10 sessions of 20 minutes of sham electrical stimulation on consecutive days

Intervention Type DEVICE

Other Intervention Names

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tDCS

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of autism spectrum disorder by a psychiatrist and behavioral checklist
* being 6-16 years old
* providing written informed consent signed by parents

Exclusion Criteria

* comorbidity with other neurodevelopmental disorders
* comorbidity with other neurological disorders
* previous history of neurosurgery
* presence of any ferromagnetic metal in the head
* implanted medical devices in the head or neck region
* history of noncontrolled epilepsy with seizures in the last year
Minimum Eligible Age

7 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ardabil University of Medical Sciences

OTHER

Sponsor Role collaborator

Leibniz Research Centre for Working Environment and Human Factors

OTHER

Sponsor Role collaborator

University of Tehran

OTHER

Sponsor Role collaborator

The National Brain Mapping Laboratory (NBML)

OTHER

Sponsor Role lead

Responsible Party

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Mohammad Ali Salehinejad

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The National Brain Mapping Laboratory (NBML)

Tehran, , Iran

Site Status

Countries

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Iran

Other Identifiers

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IR.ARUMS.REC.1395.20

Identifier Type: -

Identifier Source: org_study_id

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