Molecular Subtyping for Prognosis Evaluation in Resected Pancreatic Adenocarcinoma

NCT ID: NCT05483257

Last Updated: 2022-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

226 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-14

Study Completion Date

2021-09-13

Brief Summary

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Pancreatic adenocarcinoma (PAAD) patients following surgeries are prone to relapse shortly, while it is not well understood by current biomarkers. Given the potential associations of human leukocyte antigen class I (HLA-I) genotype with oncogenic mutational profile and immunotherapy efficacy, we aimed to assess whether differential HLA-I genotype could predict the postoperative outcomes in resected PAAD patients.

Detailed Description

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Conditions

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Pancreatic Cancer Resectable

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Multigene panel for next-generation sequencing

HLA-I genotyping based on next-generation sequencing for prognosis evaluation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Radically resected pancreatic adenocarcinoma (stage I-III)
* Resected tumor tissues and matched blood cells available
* Signed informed consent

Exclusion Criteria

* Pancreatic cancer except pancreatic adenocarcinoma
* Non-radical resection
Minimum Eligible Age

34 Years

Maximum Eligible Age

84 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GeneCast Biotechnology Co., Ltd.

INDUSTRY

Sponsor Role collaborator

BAIYONG SHEN

OTHER

Sponsor Role lead

Responsible Party

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BAIYONG SHEN

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Ruijin Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

References

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Wen C, Zhang L, Yang Y, Jin Y, Ren D, Zhang Z, Zou S, Li F, Sun H, Jin J, Lu X, Xie J, Cheng D, Xu Z, Chen H, Mao B, Zhang J, Wang J, Deng X, Peng C, Li H, Jiang C, Lin L, Zhang H, Chen H, Shen B, Zhan Q. Specific human leukocyte antigen class I genotypes predict prognosis in resected pancreatic adenocarcinoma: a retrospective cohort study. Int J Surg. 2023 Jul 1;109(7):1941-1952. doi: 10.1097/JS9.0000000000000264.

Reference Type DERIVED
PMID: 37026827 (View on PubMed)

Other Identifiers

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M-Cli200633-PC

Identifier Type: -

Identifier Source: org_study_id

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