A New Prognostic Score Model for Pancreatic Ductal Adenocarcinoma

NCT ID: NCT05547074

Last Updated: 2022-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

302 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-01

Study Completion Date

2022-08-31

Brief Summary

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The AJCC TNM staging system is the prevailing method in prognostic evaluation of pancreatic ductal adenocarcinoma (PDAC) at present , but it did not include factors such as the tumor immune microenvironment that are known to exert a profound impact on patients'clinical outcome. This study was aimed to develop a comprehensive and effective prognostic score model to predict prognosis and guide clinical management for postoperative PDAC patients.

Detailed Description

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Conditions

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Neoplasms Pancreatic

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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The training cohort

To develop the prognostic model, 302 cases of postoperative PDAC were included in the final analysis and divided into the training and validation cohort by stratified sampling with 7:3 ratio (The training cohort: n=212; The validation cohort: n=90).

pancreatic cancer surgery

Intervention Type PROCEDURE

Surgical resection of pancreatic cancer,including radical or palliative surgery

The validation cohort

To develop the prognostic model, 302 cases of postoperative PDAC were included in the final analysis and divided into the training and validation cohort by stratified sampling with 7:3 ratio (The training cohort: n=212; The validation cohort: n=90).

pancreatic cancer surgery

Intervention Type PROCEDURE

Surgical resection of pancreatic cancer,including radical or palliative surgery

Interventions

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pancreatic cancer surgery

Surgical resection of pancreatic cancer,including radical or palliative surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Pathologically confirmed PDAC
2. Achievement of surgical resection (including radical or palliative surgery)

Exclusion Criteria

1. Lost to follow-up
2. Simultaneous presence of other tumors
3. Died in three months after surgery
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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TingBo Liang

Head of Hepatobiliary and Pancreatic Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tingbo Liang

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital, Medical College of Zhejiang University

Locations

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First Affiliated Hospital, Medical College of Zhejiang University

Hangzhou, Zhejiang, China

Site Status

Countries

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China

Other Identifiers

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PSMPDAC

Identifier Type: -

Identifier Source: org_study_id

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