Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis

NCT ID: NCT02869802

Last Updated: 2025-09-22

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 190 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-10-06
• Study Completion Date: 2027-12-31

Brief Summary

Researchers are looking for better ways of understanding and treating pancreatic cancer. The purpose of this study is to see how useful it is to look for changes and characteristics in your genes (molecules that contain instructions for the development and functioning of the cells) and the genes within the tumour. These characteristics may be useful in choosing treatments for patients in the future. Changes (mutations) in genes have been shown to be an important characteristic in cancers. Looking at differences in genes in patients with advanced pancreatic ductal adenocarcinomas and comparing this information with response to their initial chemotherapy treatment may help to learn which treatments may be better for certain patients after initial treatment.

Detailed Description

This is a prospective non-randomized study of patients with metastatic pancreatic ductal adenocarcinoma (PDAC) undergoing first-line systemic chemotherapy with either folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or gemcitabine and nab-paclitaxel (GP)-based regimens, where tumour samples, baseline and serial blood samples, and standardized clinical and radiological assessments will be obtained. Patients planned for treatment with an investigational agent(s) within a clinical trial using either FOLFIRINOX or GP as the chemotherapy backbone will also be eligible, as long other eligibility criteria for the study are met.

A total of 190 patients will be recruited over the study period. Patients will undergo fresh tumour biopsy at study baseline for comprehensive molecular characterization (biopsy cohort). Patients whose biopsy was unable to undergo whole genome and transcriptome sequencing (e.g. due to insufficient tumour content) but fulfill all other eligibility criteria will comprise the archival cohort, where limited genomic analyses will be performed on archival tumour samples. Patients with a radiological diagnosis of metastatic PDAC without a confirmatory histological diagnosis may be eligible; in these cases, tumour biopsy for establishing a pathological diagnosis will be given first priority. Remaining tumour samples will be used for research purposes only after the diagnosis of PDAC has been established. In the rare event (<5%) where the histological diagnosis is other than PDAC, patients will be censored from the study and all tumour materials stored for future clinical use outside of this study.

All patients will undergo serial collection of plasma and serum samples at baseline and every cycle of chemotherapy or every 4 weeks, whichever is longer, until end of study. These samples will be used for exploratory biomarker analyses. Serum cancer antigen 19-9 (CA19-9), also known as carbohydrate antigen 19-9, will also be measured at baseline and every cycle of chemotherapy or every 4 weeks thereafter, whichever is longer, as part of routine standard of care until end of study. In addition, a whole blood sample will be collected at baseline to study germline DNA variants. CT chest, abdomen and pelvis will be performed at baseline and every 8 weeks, with radiological response to therapy assessed using RECIST 1.1.

Patients must have at least one tumour lesion amenable to biopsy from which a minimum of 3 tumour cores can be safely obtainable under CT or ultrasound guidance, as assessed by a staff interventional radiologist. A maximum of 5 tumour cores will be taken from each patient at baseline prior to treatment with FOLFIRINOX or GP. At the time of radiological disease progression, an optional second tumour biopsy will be collected from patients in the biopsy cohort to study changes in the molecular characteristics of tumours under the selection pressure of first-line systemic therapy. This tumour biopsy will be performed using exactly the same procedures described for the baseline biopsy. Tumour biopsies will be coordinated with the British Columbia (BC) Cancer Personalized Oncogenomics (POG) program and the data and/or samples shared between the two studies to avoid re-sampling the patient for both POG and PanGen, if the patient is participating in both studies. Molecular analyses will be performed by BC Cancer. Depending on the amount of tumour material obtained from each patient, molecular analyses will be prioritized to first establish or confirm histological diagnosis and then use for whole genome sequencing, whole transcriptome sequencing, proteomics, and patient-derived models.

The primary endpoint of PanGen is the generation of molecular and phenotypic signatures of individual tumours in a clinically relevant timeframe. The signature data will be correlated with clinical outcome. One of the key strengths of this cohort approach will be the rigorous annotation of PDAC patients' clinical features and outcomes to all treatments (first-line and other) linked to the molecular profile. The investigators have the potential to be nimble as more data is generated, more hypotheses can be explored and others fine-tuned or eliminated.

Conditions

Cancer; Pancreatic Cancer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Biopsy Cohort

Participants will undergo a tumour biopsy at baseline and an optional tumour biopsy at disease progression.

Participants will undergo serial collection of plasma and serum samples.

Tumour Biopsy

Intervention Type: PROCEDURE

If there is the presence of a tumour lesion amenable to core needle biopsy as judged by a staff interventional radiologist, a minimum of 3 tumour cores will be obtained under CT or US guidance.

Serial Collection of Plasma and Serum Samples

Intervention Type: OTHER

Participants will undergo serial collection of plasma and serum samples at baseline and every cycle of chemotherapy or every 4 weeks, whichever is longer, until end of study.

Archival Cohort

Genomic analyses will be performed on participants' archival tumour samples.

Participants will undergo serial collection of plasma and serum samples.

Serial Collection of Plasma and Serum Samples

Intervention Type: OTHER

Participants will undergo serial collection of plasma and serum samples at baseline and every cycle of chemotherapy or every 4 weeks, whichever is longer, until end of study.

Interventions

Tumour Biopsy

If there is the presence of a tumour lesion amenable to core needle biopsy as judged by a staff interventional radiologist, a minimum of 3 tumour cores will be obtained under CT or US guidance.

Intervention Type: PROCEDURE

Serial Collection of Plasma and Serum Samples

Participants will undergo serial collection of plasma and serum samples at baseline and every cycle of chemotherapy or every 4 weeks, whichever is longer, until end of study.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Histological and/or radiological diagnosis of metastatic PDAC. Patients without a histological diagnosis of PDAC must undergo confirmatory tumour biopsy prior to treatment start date.
• Planned for first-line systemic therapy with FOLFIRINOX or GP, either in routine care or in combination with an investigational agent(s) within a clinical trial.
• Age ≥ 18 years
• Eastern Cooperative Oncology Group (ECOG) performance status 0-1
• Adequate organ function
• Life expectancy of > 90 days as judged by the investigator
• Ability to give informed consent
• Measurable disease by RECIST 1.1
• Presence of a tumour lesion amenable to core needle biopsy as judged by a staff interventional radiologist. A minimum of 3 tumour cores must be safely obtainable under CT or US guidance.
• Fit enough to safely undergo a tumour biopsy as judged by the investigator
• Ability to lie supine for > 60 minutes

Patients in the archival cohort must also fulfil the following criteria:

• Archival tumour sample available (either a previous tumour diagnostic biopsy or resection specimen)

Exclusion Criteria

• Absence of distant or lymph node metastases. Patients with borderline resectable or locally advanced PDAC are not eligible.
• Received prior systemic therapy (chemotherapy or any other anti-cancer agent) in the advanced setting. Patients who received adjuvant chemotherapy after surgical resection of early stage disease are eligible.
• Currently receiving anti-cancer therapy (chemotherapy or any other anti-cancer agent)
• Not fit for combination chemotherapy as judged by the investigator
• Presence of brain metastases
• Female patients with positive pregnancy test
• Patients who are not safe to include in the study as judged by the investigator for any medical or non-medical reason
• Unable to comply with study assessments and follow-up

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Terry Fox Research Institute

OTHER

Sponsor Role: collaborator

BC Cancer Foundation

OTHER

Sponsor Role: collaborator

Pancreas Centre BC

OTHER

Sponsor Role: collaborator

American Society of Clinical Oncology

OTHER

Sponsor Role: collaborator

British Columbia Cancer Agency

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Daniel J Renouf, MD

Role: PRINCIPAL_INVESTIGATOR

BC Cancer

Locations

Tom Baker Cancer Centre

Calgary, Alberta, Canada

Site Status: RECRUITING

Cross Cancer Institute

Edmonton, Alberta, Canada

Site Status: WITHDRAWN

BC Cancer - Vancouver

Vancouver, British Columbia, Canada

Site Status: RECRUITING

The Ottawa Hospital

Ottawa, Ontario, Canada

Site Status: ACTIVE_NOT_RECRUITING

Countries

Canada

Central Contacts

Daniel J Renouf, MD

Role: CONTACT

drenouf@bccancer.bc.ca

800-663-3333

Facility Contacts

Patricia Tang, MD

Role: primary

Patricia.Tang@albertahealthservices.ca

403-521-3723

Daniel J Renouf, MD

Role: primary

drenouf@bccancer.bc.ca

6048776000 ext. 2445

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Related Links

https://database.ich.org/sites/default/files/E6_R2_Addendum.pdf

Integrated Addendum to International Council for Harmonization (ICH) E6(R1): Guideline for Good Clinical Practice ICH E6(R2)

Other Identifiers

H16-00291

Identifier Type: OTHER

Identifier Source: secondary_id

H20-02375

Identifier Type: -

Identifier Source: org_study_id