Systematic Hereditary Pancreatic Cancer Risk Assessment and Implications for Personalized Therapy

NCT ID: NCT03060720

Last Updated: 2025-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

271 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-24

Study Completion Date

2026-02-28

Brief Summary

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This research study is looking at people with cancer of the pancreas to find clinical factors that can explain the presence of genetic mutations

Detailed Description

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This research is being done to identify which pancreatic cancer patients should undergo genetic evaluation. A patient's personal and family history of cancer is the information typically used to make this decision, but there are currently no accurate, evidence-based guidelines that exist to help doctors use this information to make a decision.

The investigators hope that by testing all new pancreatic cancer patients, they can determine which clinical factors predict for genetic mutations in order to create a risk assessment tool.

The investigators want to determine which patients with pancreatic cancer will benefit from genetic testing. To do so, the investigators will offer all patients with pancreatic cancer in the Dana-Farber Gastrointestinal Oncology clinic referral for genetic evaluation. At the Cancer Genetics and Prevention clinic appointment, the provider will review the patient's personal and familial history of cancer and offer genetic testing.

Conditions

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Pancreatic Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of pancreatic ductal adenocarcinoma
* Signed initial informed consent
* Participant agrees to genetic counseling

Exclusion Criteria

* Prospective participant unable to sign informed consent based on referring physician recommendation.
* Patient has neuroendocrine pancreatic tumor
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Dana-Farber Cancer Institute

OTHER

Sponsor Role lead

Responsible Party

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Matthew B. Yurgelun, MD

Matthew B. Yurgelun, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Matthew B Yurgelun, MD

Role: PRINCIPAL_INVESTIGATOR

Dana-Farber Cancer Institute

Locations

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Dana Farber Cancer Institute

Boston, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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P50CA127003

Identifier Type: NIH

Identifier Source: secondary_id

View Link

16-448

Identifier Type: -

Identifier Source: org_study_id

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