Real-life Use of Cefazolin for the Treatment of Meticillin-susceptible Staphylococcal Infective Endocarditis: Comparison to a Treatment Cohort With Penicillin M
NCT ID: NCT05474118
Last Updated: 2022-07-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
192 participants
OBSERVATIONAL
2020-02-05
2022-03-31
Brief Summary
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Detailed Description
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There is currently no clinical data to prejudge the efficacy of Cefazolin in the context of high inoculum, such as in the treatment of infective endocarditis.
On the other hand, recent data have described a better tolerance profile for Cefazolin than for Penicillin M.
The objective of this study is to compare the efficacy and safety of Cefazolin with that of Penicillin M in the management of methicillin-susceptible staphylococcal endocarditis, through the analysis of two retrospective cohorts.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Documented SAMS or meticillin-sensitive SCN
* Treated with Cefazolin or Penicillin M for at least 10 consecutive days
* Treatment initiated between 01/01/2014 and 12/31/2018
Exclusion Criteria
* Patients under 18 years old.
18 Years
ALL
No
Sponsors
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Centre Hospitalier Annecy Genevois
OTHER
Responsible Party
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Principal Investigators
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Mylène Maillet
Role: PRINCIPAL_INVESTIGATOR
CH Annecy Genevois
Locations
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Centre Hospitalier Annecy Genevois
Metz-Tessy, , France
Countries
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Other Identifiers
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18-45b
Identifier Type: -
Identifier Source: org_study_id
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