Maternal Probiotic Supplementation for Improved Outcomes in Infants of Diabetic Mothers

NCT ID: NCT05467150

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-17

Study Completion Date

2026-08-31

Brief Summary

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The purpose of this study is to test the hypothesis that maternal probiotic supplementation is associated with infant gut microbiome variation and improved neurodevelopmental outcomes as measured by ERP performance in infants of diabetic mothers (IDMs), a cohort that is at-risk for recognition memory abnormalities.

Detailed Description

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Conditions

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Infant of Diabetic Mother

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Probiotic Supplement

Participants (mothers) randomized to this arm will take one Culturelle® Digestive Daily Probiotic Capsule per day from study enrollment through the first postpartum month. Each capsule contains 10 billion CFU of Lactobacillus rhamnosus GG

Group Type EXPERIMENTAL

Probiotic Supplement

Intervention Type DIETARY_SUPPLEMENT

The probiotic that will be used is Culturelle® Digestive Daily Probiotic Capsules. Each capsule contains 10 billion CFU of Lactobacillus rhamnosus GG (LGG).

No intervention

Participants (mothers) randomized to this arm will agree to continue not taking any over the counter probiotic supplements from study enrollment through the first postpartum month.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Probiotic Supplement

The probiotic that will be used is Culturelle® Digestive Daily Probiotic Capsules. Each capsule contains 10 billion CFU of Lactobacillus rhamnosus GG (LGG).

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Pregnant people in their second or third trimester with a diagnosis of gestational diabetes.
* BMI 18.5-45 kg/m2 at first prenatal visit
* Age 21-45 at time of delivery
* Report social support for and intention to exclusively breastfeed for at least 3 months
* Singleton pregnancy

Exclusion Criteria

* Alcohol consumption \>1 drink per week during pregnancy/lactation
* Tobacco consumption during pregnancy/lactation
* Inability to speak/understand English
* Known congenital metabolic, endocrine disease (other than GDM), or congenital illness affecting infant feeding
* History of type I Diabetes
* Birthing parent currently taking over the counter probiotic preparation
Minimum Eligible Age

21 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Minnesota

Minneapolis, Minnesota, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Marie Hickey Swanson, MD

Role: CONTACT

612-626-0644

Facility Contacts

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Marie Hickey Swanson, MD

Role: primary

612-626-0644

Other Identifiers

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PEDS-2022-29947

Identifier Type: -

Identifier Source: org_study_id

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