DYNAMX Bioadaptor ImplanTation for the trEatment of Complex Coronary Lesions

NCT ID: NCT05464147

Last Updated: 2023-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-19

Study Completion Date

2024-10-31

Brief Summary

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The aim of the DYNAMITE study is to investigate the (a) acute procedural and (b) 9-month follow-up performance of DynamX Drug-Eluting Coronary Bioadaptor System implantation in complex coronary lesions.

Detailed Description

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Conditions

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Coronary Artery Disease Chronic Total Occlusion of Coronary Artery Bifurcation of Coronary Artery Multi Vessel Coronary Artery Disease Long Lesions Coronary Artery Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

All imaging analyses will be performed at an independent core laboratory (Cardiovascular Department, San Giovanni Addolorata Hospital, Rome, Italy) by experienced operators blinded to procedural data and clinical outcomes.

Study Groups

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DynamX Drug-Eluting Coronary Bioadaptor System

Group Type EXPERIMENTAL

DynamX Drug-Eluting Coronary Bioadaptor System

Intervention Type DEVICE

DynamX Drug-Eluting Coronary Bioadaptor System Implantation in Coronary Artery Lesion

Interventions

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DynamX Drug-Eluting Coronary Bioadaptor System

DynamX Drug-Eluting Coronary Bioadaptor System Implantation in Coronary Artery Lesion

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Presence of complex coronary lesions defined as follows:

* long lesions (\>28 mm);
* CTO, a total occlusion of duration more than 3-months;
* Lesions involving a bifurcation, defined as a division with a side branch large enough to be stented (i.e. \>2.25 mm);
* Patients requiring 4 or more stents
* Reference vessel diameter: \>2.25 mm to \<4.0 mm

Exclusion Criteria

* Age under 18 years old;
* Significant co-morbidity precluding clinical follow-up;
* A positive pregnancy test in women with child-bearing potential;
* Contra-indication to dual anti-platelet therapy;
* Thrombocytopenia \<100,000/uL;
* Major surgery planned which will lead to discontinuation of antiplatelet therapy;
* In-stent restenosis;
* Treatment of saphenous vein graft;
* CTO with long sub-intimal tracking (\> 20 mm).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Istituto Clinico Humanitas

OTHER

Sponsor Role collaborator

Elixir Medical Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Dr. Antonio Colombo

Dr. Antionio Colombo, Senior Consultant - Cardio Center, Clinical and Interventional Cardiology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Humanitas Research Hospital

Rozzano, , Italy

Site Status

Countries

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Italy

Other Identifiers

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250521

Identifier Type: -

Identifier Source: org_study_id

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