Observation of the Efficacy of Different Vitrectomy Systems to Treat Proliferative Diabetic Retinopathy

NCT ID: NCT05446948

Last Updated: 2023-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-11

Study Completion Date

2023-06-01

Brief Summary

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In recent years, vitrectomy has moved toward a minimally invasive vitrectomy surgery (MIV) system, which could effectively reduce the occurrence of operation complications, while reducing the time of post-operation recovery.

With an improved design of bevel tip and a high cutting rate capacity of 10000cpm, Advanced ULTRAVIT® probes potentially provide an strong technical support for the application of MIV. The new probe facilitates great control during delicate surgical maneuvers, such as separating the hyaloid from the retinal surface, dissecting fibrovascular tissue off the surface of retina.

However, there was no sufficient clinical evidence to support the benefits of Advanced ULTRAVIT ® probes in the complicated vitreoretinal surgery, such as proliferative diabetic retinopathy. More importantly, there is an urgent need of clinical evidence to support 10000cpm launch and conversion which is major objective of 2021 VR growth strategies.

Detailed Description

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This exploratory study, aiming to demonstrate the beneficial of 27 Gauge probe, which can be flexibly applied as a multifunctional tool for membrane removal by reducing frequencies of switching device, reducing the traction to eyeball during device entering and leaving the eye. Moreover, the outcomes from this study would be an strong evidence to support further comparative study to comprehensively demonstrate the superior function compare to current heavily used 5K 25 gauge probe.

Conditions

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Proliferative Diabetic Retinopathy Vitrectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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beveled 27G+ group

The group of patients underwent vitrectomy with a beveled 27G+ vitrectomy system.

Group Type EXPERIMENTAL

beveled 27G+ vitrectomy system

Intervention Type DEVICE

The device is a novel 27G+ vitrectomy system, whose probe tip is beveled.

25G+ group

The group of patients underwent vitrectomy with a standard 25G+ vitrectomy system.

Group Type ACTIVE_COMPARATOR

standard 25G+ vitrectomy system

Intervention Type DEVICE

The device is a traditional instrument, and its probe tip is flat.

Interventions

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beveled 27G+ vitrectomy system

The device is a novel 27G+ vitrectomy system, whose probe tip is beveled.

Intervention Type DEVICE

standard 25G+ vitrectomy system

The device is a traditional instrument, and its probe tip is flat.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patients with vitreous hemorrhage and tractional retinal detachment (TRD) confirmed by fundus image and B ultrasound examination, consistent with the diagnosis of severe proliferated diabetic retinopathy (PDR).
2. Patient that could follow up postoperatively at the clinic for 6 months more.
3. All the surgeries were performed by one well-experienced retinal surgeon.

Exclusion Criteria

1. Corneal lesions affecting operative field, such as corneal opacity or scar; History of vitreoretinal surgery;
2. External eye infections;
3. History of systemic thromboembolism;
4. Uncontrolled hypertension or hyperglycemia;
5. Coagulation abnormalities or currently using anticoagulant drugs other than aspirin;
6. Unable to meet postoperative position requirements;
7. Unable to be followed up regularly.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tianjin Medical University Eye Hospital

OTHER

Sponsor Role lead

Responsible Party

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Zhenchuan Zheng

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dr. Li

Role: PRINCIPAL_INVESTIGATOR

Tianjin Medical University Eye Hospital

Locations

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Tianjin Medical University Eye Hospital

Tianjin, , China

Site Status

Countries

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China

Other Identifiers

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2021KY-27

Identifier Type: -

Identifier Source: org_study_id

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