Performance, Safety and Efficiency Comparison Between 10,000 and 5,000 Cuts Per Minute Vitrectomy Using a 25G Cutter - A Prospective Randomized Controlled Study

NCT ID: NCT04859556

Last Updated: 2021-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2020-06-01

Brief Summary

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As technology advances, vitrectomy cutters are smaller and cut rates have become faster. In this prospective study, the vitrectomy efficiency and safety between 5,000 cuts per minute with 10,000 cuts per minute are compared

Detailed Description

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Purpose:

This study aims to compare the performance of the Alcon 25+® UltraVit® 5000 cpm vitrectomy probe versus the 25+® Ultravit 10,000 cpm® beveled tip, dual drive vitrectomy probe. The safety profile and efficiency were compared.

Method:

Prospective, randomised study. Consecutive patients from January 2019 to August 2019 requiring vitrectomy for retinal detachment, epiretinal membrane, vitreous haemorrhage, and macula hole were randomized into either the 10K or 5K vitrectomy group. Both groups underwent vitrectomy using the proportional vacuum mode with the cut rate set at the fastest rate. Patients with previous vitrectomy, other ocular diseases (glaucoma, corneal disease, or significant corneal opacities), or trauma were excluded from the study. The primary endpoint was vitrectomy time, while secondary endpoints included posterior vitreous detachment time, intraoperative complications, and number of instruments used. The preoperative, postoperative 1 month and 3 month best corrected visual acuity (BCVA), and complications were recorded.

Conditions

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Vitreous Hemorrhage Macula Hole Epiretinal Membrane Retinal Detachment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers
Patients and Care provider are not able to differentiate the two different cutters since the port size are the exact same for both.

Study Groups

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10k 25G cutter

New cutter, with a 10,000 cut per minute blade

Group Type EXPERIMENTAL

Alcon 25Gauge, 10,000 cuts per minute Ultravit cutter

Intervention Type DEVICE

a proprietary Vitrector from Alcon for the use on the Constellation system

5k 25G cutter

Traditional cutter, with a 5,000 cut per minute blade

Group Type ACTIVE_COMPARATOR

Alcon 25Gauge, 5,000 cuts per minute Ultravit cutter

Intervention Type DEVICE

a proprietary Vitrector from Alcon for the use on the Constellation system

Interventions

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Alcon 25Gauge, 10,000 cuts per minute Ultravit cutter

a proprietary Vitrector from Alcon for the use on the Constellation system

Intervention Type DEVICE

Alcon 25Gauge, 5,000 cuts per minute Ultravit cutter

a proprietary Vitrector from Alcon for the use on the Constellation system

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Consecutive patients over the age of 18 requiring vitrectomy for vitreous haemorrhage (VH), epiretinal membrane (ERM), macular hole (MH), dislocated lens, rhegmatogenous retinal detachment and diabetic tractional retinal detachment were randomized into the study from January 2019 till August 2019

Exclusion Criteria

* Patients with ocular comorbidities affecting surgical view including corneal opacities or scar, previous vitrectomy, history of trauma or requiring silicone oil were excluded from the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role collaborator

The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Hong Kong

Hong Kong, , Hong Kong

Site Status

Countries

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Hong Kong

Other Identifiers

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10K

Identifier Type: -

Identifier Source: org_study_id

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