Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia

NCT ID: NCT05442931

Last Updated: 2022-07-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1/PHASE2

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2022-10-30

Brief Summary

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Comparison between pregabalin and magnesium sulfate in hypotensive anaethesia

Detailed Description

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compare the effect of a single-dose 150 mg oral pregabalin and 2 grams intravenous magnesium sulfate given 30 minutes before induction of anesthesia on the total nitroglycerine used in patients undergoing functional endoscopic sinus surgery

Conditions

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Functional Endoscopic Sinus Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Pregabaline

Preoperative oral dose of pregabalin for control blood pressure and decrease dose of nitroglycerine consumption

Group Type EXPERIMENTAL

Pregabalin 150mg

Intervention Type DRUG

The oral tablet half an hour preoperative 150 milligrams

Magnesium sulfate

Preoperative intravenous dose for control blood pressure and heart rate

Group Type EXPERIMENTAL

Magnesium Sulfate

Intervention Type DRUG

Intravenous administration half an hour preoperative 2 grams

Nitroglycrine

Measuring the total dose of nitroglycerine used, using a syringe pump

Group Type EXPERIMENTAL

Nitroglycerin

Intervention Type DRUG

measure total dose of nitroglycerine in milligrams using a syringe pump

surgeon satisfaction

Intervention Type OTHER

surgeon satisfaction measured according to Likert's scale

Interventions

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Pregabalin 150mg

The oral tablet half an hour preoperative 150 milligrams

Intervention Type DRUG

Magnesium Sulfate

Intravenous administration half an hour preoperative 2 grams

Intervention Type DRUG

Nitroglycerin

measure total dose of nitroglycerine in milligrams using a syringe pump

Intervention Type DRUG

surgeon satisfaction

surgeon satisfaction measured according to Likert's scale

Intervention Type OTHER

Other Intervention Names

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Lyrica 150mg Magnisol 1gm/ 5ml Nitronal surgeon satisfaction Likert's scale

Eligibility Criteria

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Inclusion Criteria

* ASA: class 1 or 2
* Sex: male and female
* Age: from 18 to 70 years
* Patients scheduled for functional endoscopic sinus surgery

Exclusion Criteria

* Patient on diuretics, corticosteroid, pregabalin
* Patients with a history of allergy to the study drug
* Pregnancy or breastfeeding women Patients with hypertension, cardiac, renal endocrinal diseases
* uncooperative patients (cant does not administer oral tablet)
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Minia University

OTHER

Sponsor Role lead

Responsible Party

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Eman G Hassan , MD

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sarah Omar, M.D.

Role: STUDY_DIRECTOR

Minia University

Locations

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Faculty of medicine

Minya, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Eman Gamal, MD

Role: CONTACT

01032862852

Sarah Omar, MD

Role: CONTACT

01005376176

Facility Contacts

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Eman Gamal

Role: primary

01032862852

Sarah Omar, MD

Role: backup

01005376176

Other Identifiers

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55:2021

Identifier Type: -

Identifier Source: org_study_id

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