Effect of Pre-treatment With Magnesium Sulfate on the Duration of Deep Neuromuscular Blockade With Rocuronium
NCT ID: NCT02989272
Last Updated: 2016-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
60 participants
INTERVENTIONAL
2016-12-31
2017-12-31
Brief Summary
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The deep neuromuscular block is defined as the one obtained by the absence of response to the sequence of four Stimuli and the presence of one or more simple stimuli in post-tetanic counts . There is no literature description of the role of magnesium sulphate in Duration of the deep neuromuscular block obtained after the muscle relaxation of patients with rocuronium This study is justified because extending the clinical duration of neuromuscular blockers may translate into gains for surgeries that require deep and long-lasting muscle relaxation as in laparoscopic and robotic surgeries. This block allows lower inflation pressures of the pneumoperitoneum to be obtained, as a result, there is a lower inflammatory and cardiorespiratory repercussion for the patient
Detailed Description
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The principal investigator will be responsible for the delivery of sealed envelope containing the sequence of cases allocated in each of the groups to another anesthesiologist who will prepare the solution (saline or magnesium sulphate) and will record in a specific file in which group the volunteer was Allocated. Again the envelope will be sealed for tabulation later, without the knowledge of the researcher. The same principal investigator will be in charge of the measurement and recording of the data collected.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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saline group
Control group (30 patients), who will receive Treatment by venous infusion of saline solution
saline group
saline group (30 patients) who will receive pretreatment by saline solution
Sulfate group
magnesium group (30 patients) who will receive pre- Venous infusion of magnesium sulphate 60 mg / kg
Sulfate, Magnesium
magnesium group (30 patients) who will receive pretreatment by intravenous infusion of magnesium sulfate 60 mg / kg
Interventions
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Sulfate, Magnesium
magnesium group (30 patients) who will receive pretreatment by intravenous infusion of magnesium sulfate 60 mg / kg
saline group
saline group (30 patients) who will receive pretreatment by saline solution
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnancy or suspected pregnancy; Neuromuscular diseases, renal or hepatic impairment;
* Hepatic dysfunction;
* History or predictors of difficult airway; Hypermagnesemia (Mg\> 2.5 mEq / L);
* Hypomagnesemia (Mg \<1.7 mEq / L);
* Use of furosemide, aminoglycosides, aminophylline, azathioprine; Cyclophosphamide, anti-inflammatories and magnesium;
* Allergy to the drugs used in the study;
* Participants from other clinical studies.
* Emergency surgeries.
18 Years
65 Years
ALL
Yes
Sponsors
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Hospital Federal de Bonsucesso
OTHER
Responsible Party
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angelo jorge queiroz rangel micuci
Doctor Anesthesiologist
Principal Investigators
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Nubia V Figueiredo, master
Role: STUDY_DIRECTOR
Universidade Federal do Rio de Janeiro
Ismar L Cavalcanti, master
Role: STUDY_DIRECTOR
Federal Fluminense University
Angelo Jorge Q R Micuci, doctor anesthesiology
Role: PRINCIPAL_INVESTIGATOR
Hospital federal of Bonsucesso
Locations
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Bonsucesso Federal Hospital
Rio de Janeiro, Rio de Janeiro, Brazil
Countries
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Central Contacts
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Angelo Jorge Q R Micuci, doctor anesthesiology
Role: CONTACT
Phone: 21997828668
Email: [email protected]
References
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Queiroz Rangel Micuci AJ, Vercosa N, Filho PAG, de Boer HD, Barbosa DD, Cavalcanti IL. Effect of pretreatment with magnesium sulphate on the duration of intense and deep neuromuscular blockade with rocuronium: A randomised controlled trial. Eur J Anaesthesiol. 2019 Jul;36(7):502-508. doi: 10.1097/EJA.0000000000001003.
Other Identifiers
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HFBonsucesso
Identifier Type: -
Identifier Source: org_study_id