Two Approaches in Enhancing the Efficacy of Inferior Alveolar Nerve Block During Treatment of Mandibular First Permanent Molars With Symptomatic Irreversible Pulpitis

NCT ID: NCT05427903

Last Updated: 2022-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-04

Study Completion Date

2022-07-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study is designed as a randomized parallel controlled trial with three groups. Participants aged above 18 years with the first permanent molars with symptomatic signs of irreversible pulpitis will be randomly assigned into 3 groups. The first group (experimental group) will be injected with 4% articaine 1:100.000 epinephrine (inferior alveolar nerve block) will be anesthetized using 4% articaine 1:100.000 plus cryotherapy application, and the second group (experimental group) will be anaesthetised with IANB plus buccal infiltration. For the third group (control group), the mandibular molars will be anaesthetized using epinephrine using the inferior alveolar nerve block.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pain, Procedural

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Cryotherapy

Group Type EXPERIMENTAL

Buccal local anesthetic infiltration using articaine 4% 1:100000 epinephrine

Intervention Type PROCEDURE

Buccal infiltration after IANB

IANB plus buccal infiltration local anesthesia

Group Type EXPERIMENTAL

Cryotherapy

Intervention Type PROCEDURE

Ice packs application for 5 minutes after IANB injection

IANB

Group Type ACTIVE_COMPARATOR

Cryotherapy

Intervention Type PROCEDURE

Ice packs application for 5 minutes after IANB injection

Buccal local anesthetic infiltration using articaine 4% 1:100000 epinephrine

Intervention Type PROCEDURE

Buccal infiltration after IANB

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Cryotherapy

Ice packs application for 5 minutes after IANB injection

Intervention Type PROCEDURE

Buccal local anesthetic infiltration using articaine 4% 1:100000 epinephrine

Buccal infiltration after IANB

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients aged above 18 years
* Presence of at least one mandibular first permanent molar, with signs and symptoms of irreversible pulpititis

Exclusion Criteria

* Participants with a history of taking medications that could interfere with the action of the anaesthetic solutions
* Presence of paresthesia
* Presence of psychological problems
* Taking analgesics or other medications that would alter the inflammatory response of the pulp or provide analgesia 12 h pre-operatively
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Minia University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Ahmad Elheeny

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Minia University

Minya, , Egypt

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Ahmad Elheeny, PhD

Role: CONTACT

00201064257135

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Omar Ahmed

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

602

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Premedication on Post-endodontic Pain
NCT06671743 RECRUITING PHASE3