The Study on Effects of Acute Exposure to High Altitude Hypoxia on Cognitive Function in Lowlanders

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

43 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2023-12-31

Brief Summary

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The purpose of this study is to investigate the impact of rapid elevation to 3,800 meters on the cognitive function of low-altitude residents through a plateau field and plain control study, and explore the objective indicators related to the impaired cognitive function.

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Detailed Description

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This study intends to recruit 60 healthy young people residing in plain area to 3000 m. Participants were divided into two groups: the plateau group (N=30) and the plain group (N=30).

Firstly, we collected baseline data one week before the plateau group rushed to the plateau, and then repeated the above data collection at the same time on day 1 (3-5 hours after arrival), day 2, day 3, day 5, and day 7 after entering the plateau. The plain group was studied in the plain according to the same test plan.

Finally, analyze and find out the main types of cognitive impairment, and explore the physiological prediction index, including exploring the characteristics of EEG changes before and after entering the plateau.

Conditions

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Cognition

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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the plateau group

People travelling from the plains to areas at altitudes of 3800 meters

No interventions assigned to this group

the plain group

People staying in the plains throughout the whole test

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Lived in plain, never entered the plateau

Exclusion Criteria

* patients with epilepsy, migraine, brain injury, stroke and other neuropsychiatric diseases;
* central nervous system drugs;
* history of heart or head surgery;
* MMSE score \< 25;
* patients suffering from pulmonary heart disease, chronic obstructive pulmonary disease, emphysema, pulmonary embolism and other serious respiratory diseases;
* patients with negative resistance to the study and poor compliance.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes