One Research on Improving Cognitive Impairment Caused by Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

144 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-28

Study Completion Date

2020-12-31

Brief Summary

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Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive impairment caused by hypertension.

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Detailed Description

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Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive impairment caused by hypertension.

The investigators designed a multi-center randomized controlled clinical trial to study the security and effectiveness of this therapy.

Conditions

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Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental Group

Therapy A : Basic treatment + Qianyang Yuyin Granules

No interventions assigned to this group

Negative Control Group

Therapy B : Basic treatment

No interventions assigned to this group

Positive Control Group

Therapy C : Basic treatment + Donepezil

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Aged 55 to 75 years old, male or female;
* Having a history of hypertension for more than 2 years but can maintain SBP ≤ 140 mmHg and BDP ≤ 90 mmHg with medication；
* 21 ≤ MMSE \< 26, or 14 ≤ MoCA \< 26, CDR \< 0.5. Bseides, the chief complaint must happen after having hypertension；
* Meet TCM Syndrome Differentiation Standard：according to the Guidelines for the Clinical Research of Chinese Medicine New Drugs ( published by China Medical Science Press ) ：Overabundant liver-fire type：dizziness and headache, both face and eyes are red, dry mouth and bitter taste in mouth, red tongue with yellowish coating, wire and frequent pulse. Yin deficiency and yang hyperactivity type: dizziness and headache, Tinnitus and forgetfulness, sphoria with feverish sensation in chest \& palms \& soles, palpitation and insomnia, red tongue \& thin white or less coating, wiry weak and numbered pulse；
* CTMRI hint: leukoaraiosis and no sign of Cerebral infarction；
* Patients or the guardian hold the right opinions over the research and are willing to obey researcher's orders；
* Having a certain degree of education (being able to read simple newspapers in the past)；
* Patients agree to sign informed consent。

Exclusion Criteria

* Secondary hypertension；
* Taking certain kinds of antihypertensive drugs which may damage brain cognitive function；
* Diagnosed as depression or other mental disorders according to DSM-IV；
* Diagnosed as vascular dementia according to diagnostic criteria, CDR ≥ 0.5; alzheimer disease or dementia caused by some other reasons (including mixed dementia according to diagnostic criteria for VCI); cognitive impairment due to head injury。
* Suffering from certain kinds of diseases which may interfere the assessment of cognitive function, including those who are diagnosed as alcoholics and drugs or psychotropic medicine abusers during the last 5 years according to DSM-IV；
* Accompanied with severe neurological function disorder；
* Asthma, chronic severe primary cardiovascular disease, liver lesion, hematological lesions, lung diseases, diabetes or other severe diseases may influence the patients' survival such as cancer or AIDS；
* Other: Such as poor compliance, or can not attend the follow-up visit in time for some reasons；
* Taking the same kind of medicine during the last 30 days which may influence the trial；
* Is participating in another clinical study；
* Not up to TCM Syndrome Differentiation Standard。

Minimum Eligible Age

55 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No