Multimodal Approach to the Ontogenesis of Nociception in Very Preterm and Term Infants

NCT ID: NCT05404594

Last Updated: 2023-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-17

Study Completion Date

2023-04-17

Brief Summary

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The management of pain related to venipuncture remains insufficient in very preterm infants (VPI. The separation between the mother (father) and her(his) child can aggravate the short-term painful experience of the newborn. Accurate diagnosis and treatment of pain is necessary to preserve the well-being and brain development of VPI. A better understanding of the development of pain pathways and the cortical integration of nociceptive messages is essential to reach this goal.

Detailed Description

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Conditions

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Procedural Pain Pre-Term Venipuncture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Very preterm infant

Preterm infant below 33 weeks of GA

Group Type EXPERIMENTAL

Maternal vocal contact

Intervention Type BEHAVIORAL

Two consecutive venipuncture (order randomly balanced) within a short period of time will be realized with and without the presence of the mother talking/singing to her VPI infant.

In this intervention group, the mother will be supported to talk or to sing to her infants during before and during the venipuncture.

Full term neonate

Term neonate from a gestational age of 37 weeks.

Group Type ACTIVE_COMPARATOR

Maternal vocal contact

Intervention Type BEHAVIORAL

Two consecutive venipuncture (order randomly balanced) within a short period of time will be realized with and without the presence of the mother talking/singing to her VPI infant.

In this intervention group, the mother will be supported to talk or to sing to her infants during before and during the venipuncture.

Interventions

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Maternal vocal contact

Two consecutive venipuncture (order randomly balanced) within a short period of time will be realized with and without the presence of the mother talking/singing to her VPI infant.

In this intervention group, the mother will be supported to talk or to sing to her infants during before and during the venipuncture.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Experimental group: VPIs of gestational age less than or equal to 33 weeks on the day of birth and hospitalized in the neonatal intermediate care unit or the neonatal intensive care unit of the Neonatal department of the Hautepierre Hospital (Strasbourg University Hospital)

* Control group: Healthy full-term babies (\> 37 weeks gestational age) hospitalized in the maternity ward of Strasbourg University Hospital
* Consent obtained from both parents
* Subject affiliated to a social health insurance plan.

Exclusion Criteria

* \- Any malformation known before inclusion
* Cerebral lesions discovered on cerebral ultrasound performed as part of the standard management of newborns (Intra-Ventricular Hemorrhages of grade III or IV of the Papile classification, Periventricular Leucomalacia)
* Unstable clinical status according to the investigator's judgment
* Expected transfer of the child to another hospital before the term of 40 weeks PMAs.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service de Pédiatrie - Hôpital d'Hautepierre

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Pierre KUHN, Professor

Role: primary

03 88 12 77 79

Other Identifiers

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7256

Identifier Type: -

Identifier Source: org_study_id

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