Study of the Biological Function of Muscle Satellite Cells From Patients With Obstetric Brachial Plexus Palsy

NCT ID: NCT05403034

Last Updated: 2025-09-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-10-17
• Study Completion Date: 2025-06-25

Brief Summary

The purpose of this prospective work is to study the consequences of obstetrical brachial plexus paralysis on the rotator muscles of the shoulder. The hypothesis is that shoulder stiffness of these children is due to an impairment of the shoulder rotator muscles. The investigators want to test the regenerative capacities of these muscles. The development of a cellular model of this pathology will allow to test new therapeutic perspectives and to validate our hypothesis.

Detailed Description

During delivery, there can be a lesion of the nerve roots of the brachial plexus (cervical C5-C8 and/or thoracic T1 roots). The newborn presents at birth a paralysis of the arm (Obstetrical Brachial Plexus Paralysis: OBPP). One third of children with OBPP will have sequelae despite daily rehabilitation. The most frequent disability is shoulder stiffness. The current hypothesis is that this stiffness is due to a permanent imbalance between the affected shoulder muscles (lateral rotators) and the muscles less affected by the paralysis (medial rotators). Because of this imbalance, the injured shoulder is spontaneously positioned in medial rotation. This position would lead to retractions at the front of the joint despite rehabilitation. In case of incomplete recovery, growth disorders of the shoulder joint (dysplasia) appear as well as a functional handicap.

The management, from the age of 2 years, in case of shoulder stiffness and dysplasia, is surgery (arthrolysis) to regain mobility. During this operation, a muscle transfer can also be performed to strengthen the lateral rotator muscles.

However, despite surgery, mobility deficits often recur within a few years. To understand the origin of the lateral and medial rotation deficits, the investigators conducted an anatomopathological study of the rotator muscles in these children. The preliminary results show a significant damage of the rotator muscles with the presence of fibrosis which could explain the rotational stiffness and the functional impairment. To better understand the pathophysiological mechanisms, the investigatorswill set up an OBPP model in cell culture to understand the regenerative capacities and to test new pharmacological approaches.

Conditions

Obstetrical Brachial Plexus Palsy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

OBPP children

OBPP children operated on to treat shoulder stiffness.

Group Type: EXPERIMENTAL

Muscle biopsy

Intervention Type: PROCEDURE

Peroperative muscle biopsy will be performed during a planned shoulder surgery (arthrolysis and/or muscle transfer)

Interventions

Muscle biopsy

Peroperative muscle biopsy will be performed during a planned shoulder surgery (arthrolysis and/or muscle transfer)

Intervention Type: PROCEDURE

Other Intervention Names

Shoulder arthrolysis; Shoulder muscle transfer

Eligibility Criteria

Inclusion Criteria

• OBPP children with a planned shoulder surgery (arthrolysis and/or muscle transfer).

Exclusion Criteria

• other neurological disorders, post-traumatic shoulder stiffness

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 15 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role: collaborator

University Hospital, Montpellier

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Marion DELPONT, Dr

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Montpellier

Locations

Chu Montpellier

Montpellier, , France

Countries

France

Other Identifiers

2021-A02669-32

Identifier Type: OTHER

Identifier Source: secondary_id

RECHMPL21_0524

Identifier Type: -

Identifier Source: org_study_id