Traveling-wave Transcranial Electric Stimulation

NCT ID: NCT05399381

Last Updated: 2025-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-05

Study Completion Date

2026-02-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Transcranial alternating current stimulation (tACS) can non-invasively alter neuroelectric activity in the brain by applying weak time-varying electric currents via the scalp. Complex patterns of electric brain activity can take the form of traveling waves - spatially coherent brain rhythms that gradually propagate through the neocortex. Traveling waves are crucial for the temporal coordination of informational flow in the brain. Using the novel traveling-wave transcranial alternating current stimulation (tACS) approach, the investigators will explore the effects of frontal-to-parietal and parietal-to-frontal traveling waves on working memory performance and brain electrophysiology in adults.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Working Memory

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Frontoparietal Slow Theta Stimulation

Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min.

Group Type EXPERIMENTAL

Transcranial alternating current stimulation (tACS)

Intervention Type DEVICE

Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.

Frontoparietal Fast Theta Stimulation

Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min.

Group Type EXPERIMENTAL

Transcranial alternating current stimulation (tACS)

Intervention Type DEVICE

Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.

Parietofrontal Slow Theta Stimulation

Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min.

Group Type EXPERIMENTAL

Transcranial alternating current stimulation (tACS)

Intervention Type DEVICE

Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.

Parietofrontal Fast Theta Stimulation

Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min.

Group Type EXPERIMENTAL

Transcranial alternating current stimulation (tACS)

Intervention Type DEVICE

Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Transcranial alternating current stimulation (tACS)

Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Age between 18 and 45 years old.
2. Confident level of English language.

Exclusion Criteria

1. History or evidence of chronic neurological or mental disorder.
2. Metal or electric implant in the head, neck, or chest area.
3. History of head injuries with loss of consciousness.
4. Any acute or chronic medical condition that requires ongoing pharmacological treatment.
5. Pregnancy or breast-feeding.
6. Alcohol or drug addiction.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Brain & Behavior Research Foundation

OTHER

Sponsor Role collaborator

University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Ivan Alekseichuk, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

30064

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

STUDY00002876

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

HD-tDCS to Modulate Connectivity
NCT05959551 RECRUITING NA