Valuation in Depressed Mood, Anhedonia, and Anxiety

NCT ID: NCT05384158

Last Updated: 2025-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

252 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-01

Study Completion Date

2026-07-31

Brief Summary

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This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed Description

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This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Conditions

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Neurobehavioral Components of Reward and Loss Valuation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Cognitive behavioral therapy

cognitive behavioral therapy for depression, anxiety, and/or anhedonia

Group Type ACTIVE_COMPARATOR

cognitive behavioral therapy

Intervention Type BEHAVIORAL

cognitive behavioral therapy

Valuation with instruction

repeat laboratory sessions of a reward/loss learning computer game with specific instructions

Group Type ACTIVE_COMPARATOR

valuation with instruction

Intervention Type BEHAVIORAL

repeat laboratory sessions of computerized learning game

Valuation without instruction

repeat laboratory sessions of a reward/loss learning computer game without specific instructions

Group Type ACTIVE_COMPARATOR

valuation without instruction

Intervention Type BEHAVIORAL

repeat laboratory sessions of computerized learning game

Interventions

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cognitive behavioral therapy

cognitive behavioral therapy

Intervention Type BEHAVIORAL

valuation with instruction

repeat laboratory sessions of computerized learning game

Intervention Type BEHAVIORAL

valuation without instruction

repeat laboratory sessions of computerized learning game

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion Criteria

* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI
Minimum Eligible Age

25 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Virginia Polytechnic Institute and State University

OTHER

Sponsor Role lead

Responsible Party

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Pearl Chiu

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Fralin Biomedical Research Institute at Virginia Tech Carilion

Roanoke, Virginia, United States

Site Status RECRUITING

Countries

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United States

Facility Contacts

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Pearl Chiu, PhD

Role: primary

540-526-2032

Other Identifiers

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RDOC

Identifier Type: -

Identifier Source: org_study_id

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