No Post Intubation Laryngeal Symptoms

NCT ID: NCT05383417

Last Updated: 2025-09-10

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-08

Study Completion Date

2023-09-21

Brief Summary

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The purpose of the study is to test a novel endotracheal tube support device that reduces pressure of the tube on the voice box for prevention of post intubation laryngeal symptoms including sore throat, change in voice and trouble swallowing.

Detailed Description

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Single center randomized controlled trial with 100 subjects who will be intubated for already planned surgeries. The participants will be randomized into the control group or the clip group. The clip group will have a small clip (the endotracheal tube support device) placed on the endotracheal tube to reduce the pressure on the vocal cords and larynx. This endotracheal tube support device is made from a FDA approved biocompatible material.

The control group subjects will undergo their planned procedure with no intervention during intubation. The clip group will undergo their planned procedure as normal but with the endotracheal tube support device placed on the endotracheal tube by the assigned anesthesia attending physician. The clip is placed once the tube is secured and the ventilator circuit is connected. While extubating the patient, the endotracheal tube will be removed with the clip attached and a picture of the tube will be taken to record the clip location.

Before the planned procedure, the investigators will survey the participants to get a baseline for any pre-existing laryngeal symptoms. The same survey will be administered after the procedure when the participants are awake and alert just prior to discharge, 24 hours, 48 hours, and 1 week after the procedure. The survey will ask the participant to indicate "yes" or "no" for whether they are experiencing a sore throat, throat pain, oral pain, difficulty speaking, difficulty swallowing, changes in their voice, pain while speaking, and pain while swallowing. If they have indicated "yes" for any of the symptoms, the participants will also be asked to mark the severity on a visual analog scale from 1 to 10.

Other data points will also be collected in this study that are related to the intubation and participant's airway. The investigators will record the total time of the procedure and the length of time the clip is placed on the endotracheal tube. For each participant in the clip group, the investigators will also record the time it takes to place the clip on the endotracheal tube. Each participant's airway will be evaluated, and the investigators will record the thyromental distance, Mallampati score, history of difficult intubation, and the size of the endotracheal tube used. Lastly, data from each participant's intubation will be collected including number of attempts before successful intubation, incidence of dental injury, incidence of lip injury, laryngeal view on Cormack-Lehane scale, and any noted trauma upon extubation. Lastly, the investigators will have the anesthesiologists recruited for the study fill out a modified National Aeronautics and Space Administration (NASA) Task Load Index (TLX) form to evaluate the end-user experience for the device.

Conditions

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Sore-throat Dysphonia Dysphagia Intubation Complication Anesthesia Intubation Complication Anesthesia Morbidity Anesthesia Complication Anesthesia; Adverse Effect Anesthesia; Reaction Throat Disorder Throat; Wound Throat Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

2 arm parallel trial where one group will receive the endotracheal tube clip during general endotracheal anesthesia and the other group will not.
Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors
Patient will not be aware of their treatment arm. Investigator and Care Provider will be aware of treatment are but data analysis (outcomes assessor) will be blinded to treatment groups.

Study Groups

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EndoClip

Clip applied to endotracheal tube.

Group Type EXPERIMENTAL

EndoClip

Intervention Type DEVICE

Clip attached to mid portion of the endotracheal tube.

No Clip

No clip applied to endotracheal tube.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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EndoClip

Clip attached to mid portion of the endotracheal tube.

Intervention Type DEVICE

Other Intervention Names

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Endotracheal tube clip

Eligibility Criteria

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Inclusion Criteria

* Patient undergoing general endotracheal anesthesia with an endotracheal tube
* Patient is not undergoing a procedure in the head and neck region

Exclusion Criteria

* Patient with pre-existing severe sore throat, voice change, or trouble swallowing
* Patient undergoing surgery in the head and neck region
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Andrew Vahabzadeh-Hagh

Associate Professor of Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrew Vahabzadeh-Hagh, MD

Role: PRINCIPAL_INVESTIGATOR

UC San Diego Health

Locations

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UC San Diego Health

La Jolla, California, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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800842

Identifier Type: -

Identifier Source: org_study_id

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