Heart Rate Variability and Anxiety During Urinary Bladder Catheterization

NCT ID: NCT05380661

Last Updated: 2024-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-15

Study Completion Date

2024-12-31

Brief Summary

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This is a prospective, randomised study investigating the physical and psychological experience of intermittent catheterization in adult individuals following spinal cord injury (SCI).

Detailed Description

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Given that intermittent catheterization is the recommended method of bladder management in individuals with SCI, it is crucial that the potentially negative cardiovascular and psychological responses to this procedure are examined. Individuals will undergo self-catheterization, then two standard of care catheterization procedures performed by an experienced urology nurse, while either blinded to or aware of time of catheterization. Continuous cardiovascular monitoring will be in place throughout all three procedures. Assessment of anxiety will be administered pre- and post- each procedure.

Conditions

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Spinal Cord Injuries Urinary Bladder, Neurogenic Anxiety State Catheter Complications Autonomic Dysreflexia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants
Participants blinded to order of catheterization procedures conducted by the urology nurse.

Study Groups

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Individuals with motor-complete SCI

Individuals with motor sensory complete injury (AIS A/B)

Group Type EXPERIMENTAL

Self-catheterization

Intervention Type PROCEDURE

Participants will perform self-catheterization, following the same routine for intermittent catheterization at home

Catheterization performed by urology nurse, participant blinded to time of procedure

Intervention Type PROCEDURE

Participant will undergo procedure to completely empty bladder; Participant in supine position, and resting blood pressure and heart rate will be recorded for period of 5 minutes prior to catheterization; Perineum and genital areas will be draped and they will be not aware about exact timing of catheterization Catheterization will be conducted following standard clinic procedure by experience urology nurse.

Catheterization performed by urology nurse, participant aware of time of procedure

Intervention Type PROCEDURE

Participant will undergo procedure to completely empty bladder; Participant in supine position, and resting BP and HR will be recorded for period of 5 minutes prior to catheterization; Perineum and genital areas will be visible to participant and they will be fully aware about exact timing of catheterization Catheterization will be conducted following standard clinic procedure by experience urology nurse.

Individuals with motor-incomplete SCI

Individuals with motor sensory incomplete injury (AIS C/D)

Group Type EXPERIMENTAL

Self-catheterization

Intervention Type PROCEDURE

Participants will perform self-catheterization, following the same routine for intermittent catheterization at home

Catheterization performed by urology nurse, participant blinded to time of procedure

Intervention Type PROCEDURE

Participant will undergo procedure to completely empty bladder; Participant in supine position, and resting blood pressure and heart rate will be recorded for period of 5 minutes prior to catheterization; Perineum and genital areas will be draped and they will be not aware about exact timing of catheterization Catheterization will be conducted following standard clinic procedure by experience urology nurse.

Catheterization performed by urology nurse, participant aware of time of procedure

Intervention Type PROCEDURE

Participant will undergo procedure to completely empty bladder; Participant in supine position, and resting BP and HR will be recorded for period of 5 minutes prior to catheterization; Perineum and genital areas will be visible to participant and they will be fully aware about exact timing of catheterization Catheterization will be conducted following standard clinic procedure by experience urology nurse.

Interventions

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Self-catheterization

Participants will perform self-catheterization, following the same routine for intermittent catheterization at home

Intervention Type PROCEDURE

Catheterization performed by urology nurse, participant blinded to time of procedure

Participant will undergo procedure to completely empty bladder; Participant in supine position, and resting blood pressure and heart rate will be recorded for period of 5 minutes prior to catheterization; Perineum and genital areas will be draped and they will be not aware about exact timing of catheterization Catheterization will be conducted following standard clinic procedure by experience urology nurse.

Intervention Type PROCEDURE

Catheterization performed by urology nurse, participant aware of time of procedure

Participant will undergo procedure to completely empty bladder; Participant in supine position, and resting BP and HR will be recorded for period of 5 minutes prior to catheterization; Perineum and genital areas will be visible to participant and they will be fully aware about exact timing of catheterization Catheterization will be conducted following standard clinic procedure by experience urology nurse.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Male or female, 18-70 years of age
* Any chronic traumatic SCI with either motor sensory complete injury (AIS A/B, N=10) or motor sensory incomplete injury (AIS B/D, N=10).
* At least 1 year post injury, and at least 6 months from any spinal surgery
* Hand function sufficient to perform intermittent catheterization for management of urinary bladder drainage
* Must provide informed consent and be able to understand and complete study-related questionnaires (must be able to understand and speak English or have access to an appropriate interpreter as judged by the investigator)
* Willing and able to comply with clinic visit and study-related procedures

Exclusion Criteria

* Signs or known current urinary tract infection, or other inflammatory conditions of bladder/urethra
* Currently taking beta blockers or other medications that may affect heart rate
* History of ureteral injury
* History of any urinary diversion procedures, including but not limited to bladder augmentation, cystectomy, neo bladder, pouch reservoir, ileal conduit, Mitrofanoff appendicovesicostomy
* For women of childbearing potential, currently pregnant
* A member of the investigational team or his/her immediate family Presence of severe acute medical issue and use of any specific medication or treatment that, in the investigator's judgement, would adversely affect the participant's participation in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ConvaTec Inc.

INDUSTRY

Sponsor Role collaborator

Vancouver Coastal Health

OTHER_GOV

Sponsor Role collaborator

International Collaboration on Repair Discoveries

OTHER

Sponsor Role collaborator

University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Andrei Krassioukov

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrei Krassioukov, MD,PhD,FRCPC

Role: PRINCIPAL_INVESTIGATOR

University of British Columbia

Locations

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Blusson Spinal Cord Centre

Vancouver, British Columbia, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Andrea Maharaj, BSc

Role: CONTACT

(604) 675-8856

Facility Contacts

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Andrea Maharaj, BSc

Role: primary

6046758856

Other Identifiers

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H22-00971

Identifier Type: -

Identifier Source: org_study_id

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