Urodynamic Assessment of the Lower Urinary Tract: Water vs. Air

NCT ID: NCT04033770

Last Updated: 2022-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

490 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-01

Study Completion Date

2022-02-11

Brief Summary

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Comparison of water-perfused (WP) and air-charged (AC) catheters for invasive urodynamic investigation (UDI) regarding consistency, features and artifacts.

Detailed Description

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UDI is the gold standard to assess refractory lower urinary tract symptoms (LUTS), i.e. to detect and specify lower urinary tract dysfunction (LUTD). Therefore, UDI findings lead to diagnosis and decision-making for further non-invasive and invasive therapies. For UDI pressure recordings, the use of WP catheters is recommended by the International Continence Society (ICS).

Currently AC catheters have been marked for pressure recording as an alternative to WP catheters. However, the number of comparative studies is very limited. Nevertheless, since release, AC catheters have gained popularity due to their omnidirectional detection of pressure, and claimed reduction in movement artefacts (due to weight-less air column vs weighted water column), lack of external reference level, and ease of set-up/use. Still, there is debate whether AC catheters are an acceptable alternative to fluid-filled lines for measuring intravesical and intra-abdominal pressure in UDI. Based on the available literature, an appropriate conclusion, whether both systems can be used as equivalents and interchangeably, cannot be drawn.

In this study we compare both systems regarding consistency, features and artifacts.

Conditions

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Lower Urinary Tract Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Air-charged measurement system

UDI (same session repeat filling cystometry and pressure flow study) according to "Good Urodynamic Practice" recommended by the ICS but using an air-charged instead of a water-filled measurement system.

Group Type ACTIVE_COMPARATOR

Urodynamic investigation

Intervention Type OTHER

Urodynamic investigation using an air-charged measurement system

Water-perfused measurement system

UDI (same session repeat filling cystometry and pressure flow study) according to "Good Urodynamic Practice" recommended by the ICS.

Group Type ACTIVE_COMPARATOR

Urodynamic investigation

Intervention Type OTHER

Urodynamic investigation using a water-perfused measurement system

Interventions

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Urodynamic investigation

Urodynamic investigation using an air-charged measurement system

Intervention Type OTHER

Urodynamic investigation

Urodynamic investigation using a water-perfused measurement system

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male and female patients with LUTD
* Age: minimum 18 years
* Informed consent
* Competent German language skills

Exclusion Criteria

* Age \<18 years
* Pregnancy or breast feeding (see chapter 3.6.)
* Symptomatic UTI
* Individuals especially in need of protection
* No informed consent
* Patients incapable to follow the trial, e.g. because of language problems, psychiatric disorders, dementia and so on.
* Earlier participation in this clinical trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Universitätsklinik Balgrist

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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UDI-RCT 2018-00073

Identifier Type: -

Identifier Source: org_study_id

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