Correlation of Oxidative Stress and Oocyte Quality in Fertility Preservation
NCT ID: NCT05372549
Last Updated: 2025-03-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
179 participants
INTERVENTIONAL
2022-06-01
2025-01-03
Brief Summary
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In order to proceed with fertility preservation, participants will need to undergo in vitro fertilization (IVF), which is standard practice, and take stimulation medication to stimulate production of more follicles.
The combination of both Rekovelle and Menopur for fertility preservation may increase ovarian response to stimulation and increase the number of oocytes retrieved to give better chances of embryos once the oocytes will be fertilized.
The goal in this study is to understand the effect of oxydative stress on the quality of oocytes.
For the purpose of the study and to evaluate this connection, serum levels of oxidative stress and cf-DNA in your blood will be measured.
Oocyte quality will also be assessed with Magenta, a prediction tool utilizing artificial intelligence (AI). This method is non-invasive and has no risks on the oocytes.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
FACTORIAL
OTHER
NONE
Study Groups
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Oncology preservation
Oxidative stress
Oxidative stress occurs as soon as there is an imbalance between pro- / antioxidants, and molecules exhibiting antioxidant properties are at the forefront of fertility treatment and preservation. Oxidated stress will be measured by blood sample
cf-DNA
cfDNA, extracted from blood plasma in samples collected will uncover the potential role of cfDNA as a stress signal released in response to oxidative stress
MAGENTA AI
Non-invasive technique analyzing images of oocytes that can differentiate oocytes with a higher reproductive potential reflective of their quality
Social (elective) preservation
Oxidative stress
Oxidative stress occurs as soon as there is an imbalance between pro- / antioxidants, and molecules exhibiting antioxidant properties are at the forefront of fertility treatment and preservation. Oxidated stress will be measured by blood sample
cf-DNA
cfDNA, extracted from blood plasma in samples collected will uncover the potential role of cfDNA as a stress signal released in response to oxidative stress
MAGENTA AI
Non-invasive technique analyzing images of oocytes that can differentiate oocytes with a higher reproductive potential reflective of their quality
Interventions
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Oxidative stress
Oxidative stress occurs as soon as there is an imbalance between pro- / antioxidants, and molecules exhibiting antioxidant properties are at the forefront of fertility treatment and preservation. Oxidated stress will be measured by blood sample
cf-DNA
cfDNA, extracted from blood plasma in samples collected will uncover the potential role of cfDNA as a stress signal released in response to oxidative stress
MAGENTA AI
Non-invasive technique analyzing images of oocytes that can differentiate oocytes with a higher reproductive potential reflective of their quality
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Uncontrolled thyroid or adrenal dysfunction
* Tumours of the hypothalamus or pituitary gland
* Ovarian enlargement not due to polycystic ovarian syndrome
* Gynaecological haemorrhages of unknown aetiology
* Endometriosis stage III/IV
* Use of hormonal preparations (except for thyroid medication) during the last menstrual cycle
* Use of Coenzyme Q10 during the stimulation cycle
* Renal and/or hepatic impairment
* Hypersensitivity to any active ingredient or excipients in follitropin delta and/or HP-hMG
18 Years
37 Years
FEMALE
No
Sponsors
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Ferring Pharmaceuticals
INDUSTRY
Clinique Ovo
INDUSTRY
Responsible Party
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Locations
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Olive Fertility Centre
Vancouver, British Columbia, Canada
Ottawa Fertility Centre
Ottawa, Ontario, Canada
Clinique Ovo
Montreal, Quebec, Canada
Countries
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Other Identifiers
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IIS-1022
Identifier Type: -
Identifier Source: org_study_id
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