The ROAR Study: Reactive Oxygen Species and Reproduction

NCT ID: NCT06831019

Last Updated: 2025-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

1100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-01

Study Completion Date

2027-03-01

Brief Summary

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This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Detailed Description

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Conditions

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Ovarian Aging IVF Outcome Oxidative Stress

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Couples undergoing IVF

Heterosexual couples undergoing IVF

Oxidative stress markers

Intervention Type DIAGNOSTIC_TEST

We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Interventions

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Oxidative stress markers

We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Female age 18-43 years
2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
3. Male partners 18 years of age or older.
4. Must be a registered patient at UCSF Center for Reproductive Health
5. Patient and partner must both be physically present on the day of retreival

Exclusion Criteria

1. Female partner age 44 or older
2. Planning fresh transfer (hybrid PGS cycle)
3. Cleavage stage biopsy
4. Planning to use frozen sperm
Minimum Eligible Age

18 Years

Maximum Eligible Age

43 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mitchell Rosen, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Locations

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University of California, San Francisco

San Francisco, California, United States

Site Status

Countries

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United States

Central Contacts

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Elena Hoskin, BS

Role: CONTACT

(415) 885-3598

Other Identifiers

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24-42357

Identifier Type: -

Identifier Source: org_study_id

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