Intravascular Laser Irradiation of Blood Use in Poor Ovarian Responders
NCT ID: NCT05873075
Last Updated: 2024-08-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
60 participants
INTERVENTIONAL
2023-04-27
2025-12-31
Brief Summary
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Detailed Description
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Poor ovarian responders (PORs) defined as poor or no response to ovarian stimulation had poor prognosis in assisted artificial technique (ART), which is a great challenge in in vitro fertilization (IVF) cycles. Previous studies showed that treatment with anti-oxidants could improve the outcomes of the poor ovarian responders; however, the effect is limited. Since ILIB has anti-aging, anti-oxidant and anti-inflammatory effects, the investigators hypothesize that ILIB may improve ovarian function and oocyte quality in PORs. Therefore, the investigators attempt to explore the effects of ILIB on the IVF outcomes in women with poor ovarian response.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Study group
Patients received intravascular laser irradiation of blood for 20 days before IVF cycles
Intravascular laser irradiation of blood
Intravascular laser irradiation of blood via an intravenous catheter for irradiation of the blood under a period of 60 minutes daily for 20 days
Control
No intervention before IVF cycles
No interventions assigned to this group
Interventions
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Intravascular laser irradiation of blood
Intravascular laser irradiation of blood via an intravenous catheter for irradiation of the blood under a period of 60 minutes daily for 20 days
Eligibility Criteria
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Inclusion Criteria
* BMI:18-30 kg/m2
* Diminished ovarian reserve (AFC\<5, AMH\<1.2 ng/ml)
Exclusion Criteria
* Congenital uterine anomaly
* Severe intrauterine adhesion
* Severe male factor (azoospermia)
* Chromosome anomaly
* Malignancy
* Donor cycles
30 Years
44 Years
FEMALE
No
Sponsors
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Kaohsiung Veterans General Hospital.
OTHER
Responsible Party
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Li-Te Lin
Principal Investigator
Principal Investigators
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Kuan-Hao Tsui
Role: STUDY_DIRECTOR
Kaohsiung Veterans General Hospital.
Locations
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Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Kaohsiung City, , Taiwan
Countries
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References
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Momenzadeh S, Abbasi M, Ebadifar A, Aryani M, Bayrami J, Nematollahi F. The intravenous laser blood irradiation in chronic pain and fibromyalgia. J Lasers Med Sci. 2015 Winter;6(1):6-9.
Mikhaylov VA. The use of Intravenous Laser Blood Irradiation (ILBI) at 630-640 nm to prevent vascular diseases and to increase life expectancy. Laser Ther. 2015 Mar 31;24(1):15-26. doi: 10.5978/islsm.15-OR-02.
Huang SF, Tsai YA, Wu SB, Wei YH, Tsai PY, Chuang TY. Effects of intravascular laser irradiation of blood in mitochondria dysfunction and oxidative stress in adults with chronic spinal cord injury. Photomed Laser Surg. 2012 Oct;30(10):579-86. doi: 10.1089/pho.2012.3228. Epub 2012 Aug 14.
Tsai HW, Wang PH, Hsu PT, Chen SN, Lin LT, Li CJ, Tsui KH. Laser irradiation pretreatment improves endometrial preparation of frozen-thawed embryo transfer in recurrent implantation failure patients. Gynecol Endocrinol. 2020 Aug;36(8):734-738. doi: 10.1080/09513590.2020.1712694. Epub 2020 Jan 13.
Other Identifiers
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KSVGH23-CT3-20
Identifier Type: -
Identifier Source: org_study_id
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