Prospective Genetic Study in Patients With Ovarian Insufficiency

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-20

Study Completion Date

2023-12-24

Brief Summary

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genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.

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Detailed Description

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The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.

Conditions

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Premature Ovarian Failure Primary Ovarian Insufficiency Ovarian Dysgenesis Diminished Ovarian Reserve

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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IVF treatment group

Patients treated with IVF. IVF promotion process, ovulation, fertilization, embryo quality, transplantation and final outcome were collected after the treatment cycle was completed.

IVF treatment

Intervention Type PROCEDURE

Relationship between IVF treatment outcome and genotypes in POI//DOR/ovarian dysgenesis patients

No IVF treatment group

the patients who did not have received IVF treatment .Patients were followed up to collect hormone levels, ultrasound results.

No interventions assigned to this group

Interventions

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IVF treatment

Relationship between IVF treatment outcome and genotypes in POI//DOR/ovarian dysgenesis patients

Intervention Type PROCEDURE

Other Intervention Names

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No IVF treatment

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed as "premature ovarian insufficiency", "diminished ovarian reserve", "primary amenorrhea", " ovarian dysgenesis", " repeated implantation failure"

Exclusion Criteria

* To rule out polycystic ovary syndrome（PCOS）, iatrogenic factors (such as surgery, radiotherapy and chemotherapy, etc.) lead to premature ovarian insufficiency in patients

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No