Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-01

Study Completion Date

2024-01-01

Brief Summary

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Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity"). The diagnosis of these rare forms can lead to personalized management (new treatments, prognosis, adapted hygienic and dietary rules) and family screening. The use of a panel covering the known causes of monogenic obesity on a pediatric cohort of severe and early obesity will allow to evaluate the relevance of these analyses to adapt the management of this type of patients.

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Detailed Description

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Conditions

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Monogenic Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patient with salivary sampling

Salivary Sampling

Intervention Type BIOLOGICAL

The DNA study will be carried out from saliva sample

1 saliva sample per patient will be performed at the inclusion visit

Interventions

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Salivary Sampling

The DNA study will be carried out from saliva sample

1 saliva sample per patient will be performed at the inclusion visit

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Recruitment age: 2-17 years
* Body mass index, greater than the International Obesity Task Force (IOTF) 30 curve before the age of 5
* Care at the specialized pediatric obesity center (CSO) of the Bordeaux University Hospital
* Informed consent signed