Melanocortin 4 Receptor Mutations and Obesity-associated Diseases
NCT ID: NCT01849705
Last Updated: 2013-05-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
226 participants
OBSERVATIONAL
2012-10-31
2013-02-28
Brief Summary
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Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.
The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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All subjects
No intervention
No intervention
Interventions
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No intervention
Eligibility Criteria
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Inclusion Criteria
* Men and women
* BMI \> 30 kg/m\^2
Exclusion Criteria
* Bariatric surgery
* Use of anti-obesity medication
18 Years
70 Years
ALL
Yes
Sponsors
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Rhythm Pharmaceuticals, Inc.
INDUSTRY
University of Copenhagen
OTHER
Responsible Party
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AAstrup
MD, Professor
Principal Investigators
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Arne Astrup, MD, Dr. Med
Role: STUDY_DIRECTOR
Department of Human Nutrition, University of Copenhagen
Lesli H Larsen, PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Human Nutrition, University of Copenhagen
Locations
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Department of Nutrition, Exercise and Sports, University of Copenhagen
Frederiksberg, Frederiksberg C, Denmark
Countries
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Other Identifiers
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H-2-1012-108
Identifier Type: REGISTRY
Identifier Source: secondary_id
B-298
Identifier Type: -
Identifier Source: org_study_id
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