Pilot Study to Evaluate the Effect of Two Microalgae Consumption on Metabolic Syndrome

NCT ID: NCT05343858

Last Updated: 2022-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-09

Study Completion Date

2021-01-31

Brief Summary

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The purpose of this study is to evaluate the effect of the consumption of two microalgae Chlorella vulgaris and Arthrospira platensis (Spirulina) on some biomarkers of metabolic syndrome: Total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, Apolipoprotein A and Apolipoprotein B, in overweight / obese subjects with altered lipid profile.

Detailed Description

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A randomized, parallel, and double-blind pilot study with 3 study arms is being performed to evaluate the effect of the consumption of two unicellular microalgae: Chlorella vulgaris and Arthrospira platensis (Spirulina).

The investigators included 30 participants between 18 and 65 years (BMI ≥25 and \<40 kg / m2). All volunteers will be randomized into 3 study groups, and participants will receive the 3 different study products during 30 days.

Conditions

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Metabolic Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Group 1: Spirulina platensis

10 volunteers will consume 16g / day (in 2 doses of 8g) of a nutritional supplement of Spirulina platensis

Group Type EXPERIMENTAL

Experimental: Group 1: Spirulina platensis

Intervention Type DIETARY_SUPPLEMENT

16 g/day (two doses of 8g)

Group 2: Chlorella vulgaris

10 volunteers will consume 16g / day (in 2 doses of 8g) of a nutritional supplement of Chlorella vulgaris

Group Type EXPERIMENTAL

Experimental: Group 2: Chlorella vulgaris

Intervention Type DIETARY_SUPPLEMENT

16 g/day (two doses of 8g)

Group 3: Control

10 volunteers will consume 16g / day (in 2 doses of 8g) of a control supplement

Group Type PLACEBO_COMPARATOR

Placebo Comparator: Group 3: Control

Intervention Type DIETARY_SUPPLEMENT

16 g/day (two doses of 8g)

Interventions

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Experimental: Group 1: Spirulina platensis

16 g/day (two doses of 8g)

Intervention Type DIETARY_SUPPLEMENT

Experimental: Group 2: Chlorella vulgaris

16 g/day (two doses of 8g)

Intervention Type DIETARY_SUPPLEMENT

Placebo Comparator: Group 3: Control

16 g/day (two doses of 8g)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Men and women from 18 to 65 years old.
* Body Mass Index (BMI) ≥25 and \<40 kg/m2.
* Cardiovascular risk \<10%
* Adequate cultural level and understanding
* Agree to participate in the study

Exclusion Criteria

* Subjects with BMI ≥40 or \<25 kg /m2
* Subjects diagnosed with Diabetes Mellitus.
* Subjects with dyslipidemia on pharmacological treatment
* Subjects with hypertension on pharmacological treatment
* Subjects with established diagnosis of eating disorder
* Smokers or those subjects with high alcohol consumption
* Subjects under pharmacological treatment
* Subjects with large weight fluctuations of more than 4 kg or who have undergone in six months a weight loss diet
* Subjects with sensory problems
* Subjects with gastrointestinal diseases that affect the digestion or absorption of nutrients
* Pregnant or breastfeeding women
* Women with menstrual irregularities
* Subjects with intense physical activity
* Subjects with food allergies to meals included in breakfast, study product or lunch or that reject their consumption
* Subjects with a diagnosis of celiac disease or a gluten intolerance
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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AlgaEnergy, S.A.

UNKNOWN

Sponsor Role collaborator

Instituto de Investigación Hospital Universitario La Paz

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Carmen Gómez-Candela

Role: PRINCIPAL_INVESTIGATOR

La Paz University Hospital

Locations

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Institute for Health Research IdiPAZ

Madrid, , Spain

Site Status

Countries

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Spain

Other Identifiers

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HULP 5296

Identifier Type: -

Identifier Source: org_study_id

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