The Cartagena Cohort Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

619 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-03

Study Completion Date

2034-10-02

Brief Summary

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Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them.

The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance.

The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained.

A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.

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Detailed Description

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Conditions

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Cardiovascular Diseases COPD Lung Function Decreased Atherosclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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General group

18-80 years old adults from the Colombian Caribbean Coast.

Genetic risk variants

Intervention Type GENETIC

Exposure: Genetic predisposition to complex diseases.

Diet

Intervention Type OTHER

Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases.

Physical activity

Intervention Type BEHAVIORAL

Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior.

Socio-economic conditions

Intervention Type OTHER

Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others).

Interventions

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Genetic risk variants

Exposure: Genetic predisposition to complex diseases.

Intervention Type GENETIC

Diet

Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases.

Intervention Type OTHER

Physical activity

Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior.

Intervention Type BEHAVIORAL

Socio-economic conditions

Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults
* Native from Colombian Caribbean Coast

Exclusion Criteria

* Pregnant women
* Walking physical disability
* Cognitive disability
* Patients under treatment for any type of cancer
* Clinical record of primary chronic endocrine disease
* Clinical record of major respiratory tract surgery

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes