A Mobile SMART Exercise Support Program to Improve Fatigue in Lung Cancer Patients - A RCT

NCT ID: NCT05331391

Last Updated: 2022-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2024-09-30

Brief Summary

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Lung cancer (LC) is a common cancer in the world. Among all symptoms, Fatigue is considered as the most distressing medical condition of LC. Prior studies revealed that physical activity effectively relieve fatigue and related problems. The current study attempt to explore the effectiveness of SMART Exercise Support Program (SES) with the use of mobile instant messaging application, on reducing symptoms such as fatigue, and improving physical activity level, physical fitness performance, sleep quality and habits, and quality of life in advanced lung cancer (ALC) patients.

Detailed Description

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Lung cancer (LC) is the most and second most common cancer globally and locally, respectively. Nearly half of LC patients are diagnosed in the advanced stage. Fatigue is perceived to be the most distressing symptom. Physical activity has been proposed as an alternative treatment to relieve fatigue and related problems.

Mobile instant messaging applications (e.g. WhatsApp/WeChat) are popular and inexpensive for interactive messaging. A systematic review showed a majority of messaging interventions were effective in diabetes self-management, weight loss, physical activity (PA), smoking cessation, and medication adherence.

The proposed randomized controlled trial (RCT) aims to examine the effectiveness of SES on relieving fatigue, pain, dyspnea, happiness, anxiety and depression symptoms, physical activity level, physical fitness performance, sleep quality and habits, and quality of life in ALC patients (SES group), compared to the General Hygiene Information (GHI, control) group.

Questionnaires and simple fitness tests will be used at baseline, 6-week, and 24-week assessments. Qualitative feedback will be obtained at the completion of the trial.

Conditions

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Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The Experimental group will receive a brief SMART Exercise individual face-to-face session, and a package of information on lifestyle-integrated exercise and physical activity delivered through instant messaging and telephone calls.

The Control group will receive a face-to-face individual session on general hygiene (GH) information, and a package of information on GH delivered through instant messaging and telephone calls.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors
The outcome assessor did not aware of which groups the patients belongs to.

Study Groups

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Brief mobile SMART Exercise Support Program

Patients will receive a brief SMART Exercise individual session with instant messages and telephone coaching for exercise habit formation and maintenance.

Group Type EXPERIMENTAL

Brief mobile SMART Exercise Support Program

Intervention Type BEHAVIORAL

Patients will receive 1) a brief SMART Exercise individual face-to-face session; 2) a theory-based instant messaging (WhatsApp/WeChat) and telephone-delivered health coaching on a 2-stage tapering schedule. Stage 1 (week 1 to 6): daily messages and two biweekly phone calls for exercise habit formation. Stage 2 (week 7 to 12): messages twice a week and monthly phone calls for exercise habit maintenance.

General Hygiene Information (GHI)

Patients will receive an individual session, instant messages and telephone coaching regarding general hygiene information.

Group Type PLACEBO_COMPARATOR

Brief mobile SMART Exercise Support Program

Intervention Type BEHAVIORAL

Patients will receive 1) a brief SMART Exercise individual face-to-face session; 2) a theory-based instant messaging (WhatsApp/WeChat) and telephone-delivered health coaching on a 2-stage tapering schedule. Stage 1 (week 1 to 6): daily messages and two biweekly phone calls for exercise habit formation. Stage 2 (week 7 to 12): messages twice a week and monthly phone calls for exercise habit maintenance.

Interventions

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Brief mobile SMART Exercise Support Program

Patients will receive 1) a brief SMART Exercise individual face-to-face session; 2) a theory-based instant messaging (WhatsApp/WeChat) and telephone-delivered health coaching on a 2-stage tapering schedule. Stage 1 (week 1 to 6): daily messages and two biweekly phone calls for exercise habit formation. Stage 2 (week 7 to 12): messages twice a week and monthly phone calls for exercise habit maintenance.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Aged 18 years and above;
* Diagnosis of Stage III or IV non-small cell lung cancer;
* Edmonton Symptom Assessment System Scale fatigue symptom score ≥4 out of 10
* Self-reported engagement of \<150 minutes of moderate intensity PA each week,
* Ambulatory and capable of all self-care activities (European Co-operative Oncology Group (ECOG) Performance Status of ≤2)
* Either undergoing or finished oncology therapy, biological agents and/or support care;
* Mentally, cognitively and physically fit to join the trial as determined by the doctor in-charge and responsible clinical investigators;
* Able to speak and read Chinese;
* Willing to complete the patient-reported outcome questionnaire;
* Completion of the Physical Activity Readiness Questionnaire; and
* Possession of a smartphone with instant messaging functions such as WhatsApp or WeChat.

Exclusion Criteria

* Those preparing for lung operation;
* Skeletal fragility;
* Serious active infection;
* Inability to walk;
* Previously untreated symptomatic brain metastases;
* Severe respiratory insufficiency;
* Uncontrolled pain; or
* Diagnosed psychiatric illness with or without medication such as major depressive disorder.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Dr. Agnes Yuen-Kwan Lai

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Agnes YK Lai, PhD

Role: PRINCIPAL_INVESTIGATOR

School of Nursing, The University of Hong Kong

Locations

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Queen Mary Hospital

Hong Kong, , Hong Kong

Site Status RECRUITING

Countries

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Hong Kong

Central Contacts

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Agnes Lai, PhD

Role: CONTACT

852-3917-6328

George Cheung, MPhil

Role: CONTACT

852-3917-6563

Facility Contacts

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Agnes Lai, PhD

Role: primary

852-3917-6283

David Lam, PhD

Role: backup

852-2255-4455

References

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Ho RT, Fong TC. Factor structure of the Chinese version of the Pittsburgh sleep quality index in breast cancer patients. Sleep Med. 2014 May;15(5):565-9. doi: 10.1016/j.sleep.2013.10.019. Epub 2014 Feb 18.

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Jones CJ, Rikli RE, Max J, Noffal G. The reliability and validity of a chair sit-and-reach test as a measure of hamstring flexibility in older adults. Res Q Exerc Sport. 1998 Dec;69(4):338-43. doi: 10.1080/02701367.1998.10607708.

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Santos-Lozano A, Santin-Medeiros F, Cardon G, Torres-Luque G, Bailon R, Bergmeir C, Ruiz JR, Lucia A, Garatachea N. Actigraph GT3X: validation and determination of physical activity intensity cut points. Int J Sports Med. 2013 Nov;34(11):975-82. doi: 10.1055/s-0033-1337945. Epub 2013 May 22.

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Reference Type BACKGROUND
PMID: 14592388 (View on PubMed)

Other Identifiers

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UW21-148

Identifier Type: -

Identifier Source: org_study_id

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