Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.

NCT ID: NCT05330637

Last Updated: 2023-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-03

Study Completion Date

2025-04-30

Brief Summary

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To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.

Detailed Description

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The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.

1. The primary purpose is to investigate the influence of the unique tropical climate and environmental factors on the migratory old people with diseases such as asthma, allergic rhinitis, COPD or atopic dermatitis in Sanya from northern China, and to provide scientific evidence for publicity of the tourism and the health care industry.
2. The secondary purpose is to investigate prevalence and risk factors of asthma, allergic rhinitis and atopic dermatitis among children in Sanya, which will provide a base for prevention and control strategies.
3. The third purpose is to retrospectively analyze the influence of climate and environmental factors in Sanya on children with asthma, allergic rhinitis and atopic dermatitis in the past decade, and a comparative analysis of the incidence on children in Sanya and Shanghai.

Conditions

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Asthma Allergic Rhinitis Chronic Obstructive Pulmonary Disease(COPD) Atopic Dermatitis Eczema Urticaria Bronchitis Bronchiectasis Adult Emphysema

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Migratory old people with asthma from northern China in Sanya

Migratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Migratory old people with allergic rhinitis from northern China in Sanya

Migratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya

Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Migratory old people with atopic dermatitis from northern China in Sanya

Migratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Children with asthma in Sanya

Children with asthma have being exposure to tropical climate and environment in Sanya for years.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Children with allergic rhinitis in Sanya

Children with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Children with atopic dermatitis in Sanya

Children with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Children with eczema in Sanya

Children with eczema have being exposure to tropical climate and environment in Sanya for years.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Children with urticaria in Sanya

Children with urticaria have being exposure to tropical climate and environment in Sanya for years.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Migratory old people with eczema from northern China in Sanya

Migratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Migratory old people with urticaria from northern China in Sanya

Migratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Climate and environment in Sanya

Intervention Type OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Interventions

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Climate and environment in Sanya

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
* 3-12 years-old children in Sanya;
* Agree to participate this study.

Exclusion Criteria

* Disagree to participate this study;
* Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
* Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.
Minimum Eligible Age

3 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shijian Liu, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine

Locations

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Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University

Sanya, Hainan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shijian Liu, Ph.D

Role: CONTACT

86-21-38087983

Facility Contacts

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Haidao Guan, BD

Role: primary

86-0898-88360093

References

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Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Xu G, Wu S, Wang C, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Zhang B, Xiao D, Wang Z, Chen Z, Bu X, Zhang H, Zhang X, An L, Zhang S, Zhu J, Cao Z, Zhan Q, Yang Y, Liang L, Tong X, Dai H, Cao B, Wu T, Chung KF, He J, Wang C; China Pulmonary Health (CPH) Study Group. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019 Aug 3;394(10196):407-418. doi: 10.1016/S0140-6736(19)31147-X. Epub 2019 Jun 20.

Reference Type RESULT
PMID: 31230828 (View on PubMed)

Xie L, Liu Z, Hao S, Wu Q, Sun L, Luo H, Yu R, Li X, Wu X, Li S. Assessment of knowledge, attitude, and practice towards pulmonary rehabilitation among COPD patients: A multicenter and cross-sectional survey in China. Respir Med. 2020 Nov-Dec;174:106198. doi: 10.1016/j.rmed.2020.106198. Epub 2020 Oct 20.

Reference Type RESULT
PMID: 33120194 (View on PubMed)

Zhu B, Wang Y, Ming J, Chen W, Zhang L. Disease burden of COPD in China: a systematic review. Int J Chron Obstruct Pulmon Dis. 2018 Apr 27;13:1353-1364. doi: 10.2147/COPD.S161555. eCollection 2018.

Reference Type RESULT
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Ding Y, Xu J, Yao J, Chen Y, He P, Ouyang Y, Niu H, Tian Z, Sun P. The analyses of risk factors for COPD in the Li ethnic group in Hainan, People's Republic of China. Int J Chron Obstruct Pulmon Dis. 2015 Nov 30;10:2593-600. doi: 10.2147/COPD.S86402. eCollection 2015.

Reference Type RESULT
PMID: 26664107 (View on PubMed)

Garcia-Almaraz R, Reyes-Noriega N, Del-Rio-Navarro BE, Berber A, Navarrete-Rodriguez EM, Ellwood P, Garcia Marcos Alvarez L; GAN Phase I group. Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organ J. 2020 Dec 5;14(1):100492. doi: 10.1016/j.waojou.2020.100492. eCollection 2021 Jan.

Reference Type RESULT
PMID: 34659624 (View on PubMed)

Pesce G, Bugiani M, Marcon A, Marchetti P, Carosso A, Accordini S, Antonicelli L, Cogliani E, Pirina P, Pocetta G, Spinelli F, Villani S, de Marco R. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy. Sci Total Environ. 2016 Feb 15;544:645-52. doi: 10.1016/j.scitotenv.2015.12.015. Epub 2015 Dec 10.

Reference Type RESULT
PMID: 26674694 (View on PubMed)

Zanolin ME, Pattaro C, Corsico A, Bugiani M, Carrozzi L, Casali L, Dallari R, Ferrari M, Marinoni A, Migliore E, Olivieri M, Pirina P, Verlato G, Villani S, Marco R; ISAYA Study Group. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: results from the Italian study of asthma in young adults. Allergy. 2004 Mar;59(3):306-14. doi: 10.1046/j.1398-9995.2003.00391.x.

Reference Type RESULT
PMID: 14982513 (View on PubMed)

Weiland SK, Husing A, Strachan DP, Rzehak P, Pearce N; ISAAC Phase One Study Group. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004 Jul;61(7):609-15. doi: 10.1136/oem.2002.006809.

Reference Type RESULT
PMID: 15208377 (View on PubMed)

Wang X, Zhuang Y, Chen Y, Wang H, Wang X. Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China. Allergy Asthma Clin Immunol. 2021 Mar 9;17(1):27. doi: 10.1186/s13223-021-00532-7.

Reference Type RESULT
PMID: 33750462 (View on PubMed)

Su N, Lin J, Chen P, Li J, Wu C, Yin K, Liu C, Chen Y, Zhou X, Yuan Y, Huang X. Evaluation of asthma control and patient's perception of asthma: findings and analysis of a nationwide questionnaire-based survey in China. J Asthma. 2013 Oct;50(8):861-70. doi: 10.3109/02770903.2013.808346.

Reference Type RESULT
PMID: 23713625 (View on PubMed)

Li J, Sun B, Huang Y, Lin X, Zhao D, Tan G, Wu J, Zhao H, Cao L, Zhong N; China Alliance of Research on Respiratory Allergic Disease. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy. 2009 Jul;64(7):1083-92. doi: 10.1111/j.1398-9995.2009.01967.x. Epub 2009 Feb 11.

Reference Type RESULT
PMID: 19210346 (View on PubMed)

Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014 Oct 6;9:1101-10. doi: 10.2147/COPD.S54475. eCollection 2014.

Reference Type RESULT
PMID: 25336941 (View on PubMed)

Kantor R, Silverberg JI. Environmental risk factors and their role in the management of atopic dermatitis. Expert Rev Clin Immunol. 2017 Jan;13(1):15-26. doi: 10.1080/1744666X.2016.1212660. Epub 2016 Jul 28.

Reference Type RESULT
PMID: 27417220 (View on PubMed)

Wang X, Li LF, Zhao DY, Shen YW. Prevalence and Clinical Features of Atopic Dermatitis in China. Biomed Res Int. 2016;2016:2568301. doi: 10.1155/2016/2568301. Epub 2016 Nov 13.

Reference Type RESULT
PMID: 27957490 (View on PubMed)

Other Identifiers

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SYFYIRB2022009

Identifier Type: -

Identifier Source: org_study_id

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