A Multi-center Study to Determine the Prevalence and Influence of Pertussis on COPD Exacerbation in Shenzhen
NCT ID: NCT04694430
Last Updated: 2021-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
500 participants
OBSERVATIONAL
2021-01-01
2021-12-31
Brief Summary
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Detailed Description
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2. To explore the relationship between pertussis infection and COPD exacerbation.
Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Study Groups
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Severe exacerbation of COPD
N = 250
Blood sample
2 ml venous blood was collected and separated into serum.
Data collection
1. Whether the patient has been vaccinated with DPT vaccine and record the time of vaccination;
2. Medication situation of patients in the past year, including rescue drugs, antitussive and expectorant drugs, inhaled corticosteroids and antibiotics;
3. Assess COPD using ABCD assessment tool.
Throat swab
Before the collection of oropharyngeal swabs, instruct the patient to wash the mouth or gargle, fix the patient's head, open the mouth and expose the throat. If necessary, use a tongue depressor to gently press the tongue.
Use the swab to wipe the secretion on both sides of the palatal arch, pharynx and tonsil with a sensitive and gentle action, and quickly withdraw the swab to avoid contacting other parts of the mouth.
Put the swab in the sterile test tube, plug the opening with cotton ball, and send it for inspection and registration in time.
Mild and moderate exacerbations of COPD
N = 250
Blood sample
2 ml venous blood was collected and separated into serum.
Data collection
1. Whether the patient has been vaccinated with DPT vaccine and record the time of vaccination;
2. Medication situation of patients in the past year, including rescue drugs, antitussive and expectorant drugs, inhaled corticosteroids and antibiotics;
3. Assess COPD using ABCD assessment tool.
Throat swab
Before the collection of oropharyngeal swabs, instruct the patient to wash the mouth or gargle, fix the patient's head, open the mouth and expose the throat. If necessary, use a tongue depressor to gently press the tongue.
Use the swab to wipe the secretion on both sides of the palatal arch, pharynx and tonsil with a sensitive and gentle action, and quickly withdraw the swab to avoid contacting other parts of the mouth.
Put the swab in the sterile test tube, plug the opening with cotton ball, and send it for inspection and registration in time.
Interventions
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Blood sample
2 ml venous blood was collected and separated into serum.
Data collection
1. Whether the patient has been vaccinated with DPT vaccine and record the time of vaccination;
2. Medication situation of patients in the past year, including rescue drugs, antitussive and expectorant drugs, inhaled corticosteroids and antibiotics;
3. Assess COPD using ABCD assessment tool.
Throat swab
Before the collection of oropharyngeal swabs, instruct the patient to wash the mouth or gargle, fix the patient's head, open the mouth and expose the throat. If necessary, use a tongue depressor to gently press the tongue.
Use the swab to wipe the secretion on both sides of the palatal arch, pharynx and tonsil with a sensitive and gentle action, and quickly withdraw the swab to avoid contacting other parts of the mouth.
Put the swab in the sterile test tube, plug the opening with cotton ball, and send it for inspection and registration in time.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
40 Years
80 Years
ALL
No
Sponsors
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Shenzhen People's Hospital
OTHER
Responsible Party
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Principal Investigators
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Lingwei Wang
Role: STUDY_DIRECTOR
Shenzhen People's Hospital
Locations
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Fuyong people's Hospital of Baoan District, Shenzhen
Shenzhen, , China
General Hospital of Shenzhen University
Shenzhen, , China
Longhua Branch of Shenzhen People's Hospital
Shenzhen, , China
Nanshan District People's Hospital
Shenzhen, , China
Peking university shenzhen hospital
Shenzhen, , China
Shenzhen Bao'an District Central Hospital
Shenzhen, , China
Shenzhen Bao'an District People's Hospital
Shenzhen, , China
Shenzhen Hospital of Beijing University of traditional Chinese Medicine
Shenzhen, , China
Shenzhen Hospital of Guangzhou University of traditional Chinese Medicine
Shenzhen, , China
Shenzhen Hospital of Southern Medical University
Shenzhen, , China
Shenzhen Hospital of the University of Hong Kong
Shenzhen, , China
Shenzhen Longgang District Central Hospital
Shenzhen, , China
Shenzhen Longgang District People's Hospital
Shenzhen, , China
Shenzhen Longgang District Second People's Hospital
Shenzhen, , China
Shenzhen Longgang District Third People's Hospital
Shenzhen, , China
Shenzhen Longhua District Central Hospital
Shenzhen, , China
Shenzhen Longhua District People's Hospital
Shenzhen, , China
Shenzhen Luohu District People's Hospital
Shenzhen, , China
Shenzhen People's Hospital
Shenzhen, , China
Shenzhen Pingshan District Hospital of traditional Chinese Medicine
Shenzhen, , China
Shenzhen Pingshan District People's Hospital
Shenzhen, , China
Shenzhen Qianhai Shekou Free Trade Zone Hospital
Shenzhen, , China
Shenzhen Second People's Hospital
Shenzhen, , China
Shenzhen TCM Hospital
Shenzhen, , China
Shenzhen Yantian District People's Hospital
Shenzhen, , China
South University of science and Technology Hospital
Shenzhen, , China
The eighth Affiliated Hospital of Sun Yat sen University
Shenzhen, , China
Countries
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Central Contacts
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Facility Contacts
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Lingwei Wang
Role: primary
Min Zhang
Role: primary
References
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Manian P. Chronic obstructive pulmonary disease classification, phenotypes and risk assessment. J Thorac Dis. 2019 Sep;11(Suppl 14):S1761-S1766. doi: 10.21037/jtd.2019.05.10.
Santus P, Pecchiari M, Tursi F, Valenti V, Saad M, Radovanovic D. The Airways' Mechanical Stress in Lung Disease: Implications for COPD Pathophysiology and Treatment Evaluation. Can Respir J. 2019 Sep 5;2019:3546056. doi: 10.1155/2019/3546056. eCollection 2019.
Canepa M, Franssen FME, Olschewski H, Lainscak M, Bohm M, Tavazzi L, Rosenkranz S. Diagnostic and Therapeutic Gaps in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease. JACC Heart Fail. 2019 Oct;7(10):823-833. doi: 10.1016/j.jchf.2019.05.009. Epub 2019 Sep 11.
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Jia JH, Guo Q, Wan CM. [Resurgence and vaccine strategies of pertussis]. Zhonghua Er Ke Za Zhi. 2020 Aug 2;58(8):686-689. doi: 10.3760/cma.j.cn112140-20200116-00036. Chinese.
Huang H, Zhu T, Gao C, Gao Z, Liu Y, Ding Y, Sun J, Guo L, Liu P, Chen D, Wang L, Wu S, Zhang Y. Epidemiological features of pertussis resurgence based on community populations with high vaccination coverage in China. Epidemiol Infect. 2015 Jul;143(9):1950-6. doi: 10.1017/S095026881400260X. Epub 2014 Oct 7.
Huang HT, Gao ZG, Liu Y, Sun J, Liu P, Wang LJ, Li Y, Zhang J, Zhang Y. [Epidemiology of pertussis in adults and related factors in Tianjin, 2005-2014]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016 May;37(5):678-81. doi: 10.3760/cma.j.issn.0254-6450.2016.05.018. Chinese.
Wang Y, Xu C, Ren J, Zhao Y, Li Y, Wang L, Yao S. The long-term effects of meteorological parameters on pertussis infections in Chongqing, China, 2004-2018. Sci Rep. 2020 Oct 14;10(1):17235. doi: 10.1038/s41598-020-74363-8.
Wang H, Zheng Y, de Groot R, Yang Y, Diavatopoulos DA, Chen Y, de Jonge MI, Deng J. High prevalence of Bordetella pertussis in young hospitalized infants with acute respiratory infection in the south of China: age- and season-dependent effects. J Infect. 2020 May;80(5):578-606. doi: 10.1016/j.jinf.2020.01.009. Epub 2020 Jan 23. No abstract available.
Other Identifiers
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WLW-COPD-Pertussis
Identifier Type: -
Identifier Source: org_study_id
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