High-frequency SCS in Treatment of Chronic Limb-Threatening Ischemia

NCT ID: NCT05322798

Last Updated: 2022-04-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-12

Study Completion Date

2021-05-30

Brief Summary

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The study of high-frequency spinal cord stimulation (SCS) efficacy in the treatment of chronic limb-threatening ischemia (CLTI)

Detailed Description

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Open-label, parallel-group, randomized study with a 1:1 allocation ratio to check the hypothesis of whether high-frequency-SCS (HF-SCS) is better than conventional low-frequency (LF-SCS) for pain relief in patients with chronic limb-threatening ischemia (CLTI).

Conditions

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Chronic Limb-Threatening Ischemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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HF-SCS

SCS system implantation with high-frequency stimulation availability

Group Type EXPERIMENTAL

High-frequency SCS

Intervention Type PROCEDURE

Continous high-frequency stimulation (frequency - 1kHz, pulse width - 30 µs).

LF-SCS

Conventional SCS system implantation

Group Type ACTIVE_COMPARATOR

Low-frequency SCS

Intervention Type PROCEDURE

Continuous conventional stimulation (frequency - 30-60 Hz, pulse width - 250-500 µs).

Interventions

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High-frequency SCS

Continous high-frequency stimulation (frequency - 1kHz, pulse width - 30 µs).

Intervention Type PROCEDURE

Low-frequency SCS

Continuous conventional stimulation (frequency - 30-60 Hz, pulse width - 250-500 µs).

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* non-reconstructable critical limb-threatening ischemia (CLTI)
* Fontaine stage IIB-IV
* VAS score 5/10 or more
* succesful SCS trial

Exclusion Criteria

* intractable acute infection
* allergy to SCS component
* ulcerations larger than 3 cm2
* inadequate patient compliance
* life expectancy less than 12 months
* patient refuse to participate in any stage of the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Meshalkin Research Institute of Pathology of Circulation

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kiril Orlov, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Meshalkin National Medical Research Centre

Locations

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Meshalkin National Medical Research Center

Novosibirsk, , Russia

Site Status

Countries

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Russia

References

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Kilchukov M, Kiselev R, Gorbatykh A, Klinkova A, Murtazin V, Kamenskaya O, Orlov K. High-Frequency versus Low-Frequency Spinal Cord Stimulation in Treatment of Chronic Limb-Threatening Ischemia: Short-Term Results of a Randomized Trial. Stereotact Funct Neurosurg. 2023;101(1):1-11. doi: 10.1159/000527309. Epub 2023 Jan 6.

Reference Type DERIVED
PMID: 36617410 (View on PubMed)

Other Identifiers

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HEAL-SCS

Identifier Type: -

Identifier Source: org_study_id

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