Quantification and Repeatability of Magnetic Stimulation

NCT ID: NCT05302752

Last Updated: 2025-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-13

Study Completion Date

2027-12-31

Brief Summary

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In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Bilateral rapid magnetic stimulation of the phrenic nerves

Each participant will be tested on three different days with optimal settings for bilateral rapid magnetic stimulation of the phrenic nerves established on visit 1 and then repeated on visits 2 and 3.

Group Type EXPERIMENTAL

Magnetic phrenic nerve stimulation

Intervention Type OTHER

The intervention consists of bilateral rapid magnetic phrenic nerve stimulation on the neck using different stimulation intensities.

On one visit, the effect of increasing chest wall stiffness and respiratory muscle work by adding incrementally small weights to the chest/abdomen will be investigated.

Interventions

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Magnetic phrenic nerve stimulation

The intervention consists of bilateral rapid magnetic phrenic nerve stimulation on the neck using different stimulation intensities.

On one visit, the effect of increasing chest wall stiffness and respiratory muscle work by adding incrementally small weights to the chest/abdomen will be investigated.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy
* non-smoking
* normal lung function
* body mass index: 18.5-29.9 kg/m2
* able to communicate in english
* willing to adhere to study rules

Exclusion Criteria

* acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
* intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
* any metal or electronics inside of the body
* presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
* history of seizures or epilepsy
* tatoos on the stimulation sites
* previous enrolment in this study
* for women: pregnancy, breastfeeding, or intention to become pregnant during the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Swiss Federal Institute of Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christina M. Spengler, Prof.

Role: PRINCIPAL_INVESTIGATOR

ETH Zurich, Exercise Physiology Lab, Institute of Human Movement Sciences and Sport

Locations

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Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Zurich, Canton of Zurich, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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REMEX-WP1

Identifier Type: -

Identifier Source: org_study_id

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