Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents
NCT ID: NCT05296213
Last Updated: 2022-04-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
45 participants
INTERVENTIONAL
2019-12-01
2022-01-10
Brief Summary
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Detailed Description
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Fluoride was considered the "gold standard" remineralizing agent , However several recent researchers found that; the ideal remineralizing agents should diffuse or deliver calcium and phosphate ions into early enamel lesion.
Calcium-silicate based material such as β-CaSiO3 and β-Ca2SiO4 play an important role in hard tissue regeneration, showing good bioactivity and biocompatibility and can induce bone like apetite formation in stimulated body fluids. when β-CaSiO3 and β-Ca2SiO4 come in contact with saliva it will be dissolve forming silanol group (Si-O ) on the enamel surface which can bind to Ca ions and inducing the precipitation of hydroxyapatite.
In the light of this, this study was designed to compare the remineralization potential of silver diamine flouride/ potassium iodide, casin phosphopeptide amorphous calcium phosphate and experimental tricalcium silicate on early enamel lesions.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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silver diamine fluoride-potassium iodide SDF-KI (riva star)
SDF-KI was applied once as a professional application over the early enamel lesions in cervical third of the buccal surface of molar teeth.
Silver diamine fluoride- potassium iodide
SDF-KI (riva star, SDI.Ltd )was applied ( as a professional application) by micro brush over the early enamel lesions on the buccal surface of molar teeth
casein phosphopeptide amorphous calcium phosphate CPP-ACP(tooth mousse)
CPP-ACP cream was applied twice daily according to manufacturer's instructions over the early enamel lesions in cervical third of the buccal surface of molar teeth.
Casein phosphopeptide amorphous calcium phosphate
CPP-ACP (tooth mousse, GC, Matraville Sydney, Australia) was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily. the patients were instructed to leave it for about 3minutes before rinsing
Experimental tricalcium silicate
Experimental tricalcium silicate paste was applied twice daily over the early enamel lesions in cervical third of the buccal surface of molar teeth
experimental tricalcium silicate
prepared tricalcium silicate paste was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily. the patients were instructed to leave it for about 3minutes before rinsing
Interventions
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Silver diamine fluoride- potassium iodide
SDF-KI (riva star, SDI.Ltd )was applied ( as a professional application) by micro brush over the early enamel lesions on the buccal surface of molar teeth
Casein phosphopeptide amorphous calcium phosphate
CPP-ACP (tooth mousse, GC, Matraville Sydney, Australia) was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily. the patients were instructed to leave it for about 3minutes before rinsing
experimental tricalcium silicate
prepared tricalcium silicate paste was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily. the patients were instructed to leave it for about 3minutes before rinsing
Eligibility Criteria
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Inclusion Criteria
* Patients with normal occlusion .
* Patients must have a good oral hygiene
* patients free from any systemic diseases and don't receive any medication
Exclusion Criteria
* pregnant females
* patients with bad oral hygiene
* patients with enamel defects ( Amelogenesis Imperfecta, fluorosis, cracks or any developmental defects)
15 Years
50 Years
ALL
Yes
Sponsors
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Mansoura University
OTHER
Responsible Party
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Locations
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Kareem Hamdi
Al Mansurah, , Egypt
Countries
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Other Identifiers
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M03060819
Identifier Type: -
Identifier Source: org_study_id
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