Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1282 participants
OBSERVATIONAL
2022-01-05
2023-01-31
Brief Summary
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The electronic health records will be queried for the demographic, medical history, and outcomes data of all patients with posterior cerebral artery occlusion who underwent mechanical thrombectomy, intravenous thrombolysis (IVT), or medical management.
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Detailed Description
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* 90-day modified Rankin Scale (mRS) ordinal shift or
* decrease in NIH Stroke Scale/Score (NIHSS) by two points at 24 hours or at hospital discharge
The secondary aims are to evaluate in patients presenting with PCA occlusion, other outcome and safety metrics:
* 90-day functional independence, mRS 0-2
* 90-day excellent outcome, mRS 0-1
* Visual field recovery (none, partial, complete) by 90-days
* rate of reperfusion by modified thrombolysis in cerebral infarction (TICI) scale grade
* any intracranial hemorrhage
* symptomatic intracranial hemorrhage
* mortality
In subgroup analysis, the investigators aim to identify subgroups that may confer differential treatment benefit by:
* location of occlusion on the PCA segment (P1, P2, P3)
* NIHSS strata (0-6, 7-15,\>16)
* time from symptom onset to treatment (0 to \<6h vs 6-24h)
* posterior circulation (PC) Acute Stroke Prognosis Early Computed Tomography Score (ASPECTS)
* visual field defect on presentation
The investigators hypothesize that greater benefit in outcomes would be seen in EVT treated patients with higher NIHSS, more proximal PCA occlusion, higher PC ASPECTS scores, and shorter time from symptom onset to treatment.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Medical management cohort
Patients who have undergone medical management stroke treatment from 1/01/2003 to 01/01/2022; this could include intravenous thrombolysis.
No interventions assigned to this group
EVT management cohort
Patients who have undergone EVT stroke treatment from 01/01/2015 to 01/01/2022
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patient with documented basilar artery occlusion, migration with secondary PCA occlusion
18 Years
89 Years
ALL
No
Sponsors
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Heidelberg University
OTHER
Boston Medical Center
OTHER
Responsible Party
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Principal Investigators
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Thanh N Nguyen, MD
Role: PRINCIPAL_INVESTIGATOR
Boston Medical Center, Neurology
Simon Nagel, MD
Role: PRINCIPAL_INVESTIGATOR
Heidelberg University Hospital, Neurology
Locations
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University of Miami
Miami, Florida, United States
Miami Baptist Health
Miami, Florida, United States
Emory University School of Medicine
Atlanta, Georgia, United States
Boston Medical Center
Boston, Massachusetts, United States
Cooper University Healthcare
Camden, New Jersey, United States
University of Buffalo
Buffalo, New York, United States
Mount Sinai Health
New York, New York, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
UT Texas Medical Center
Houston, Texas, United States
Helsinki University Hospital
Helsinki, , Finland
Charite Berlin
Berlin, , Germany
Universitätsklinikum Knappschaftskrankenhaus Bochum
Bochum, , Germany
University Clinics Dresden
Dresden, , Germany
Universitätsklinikum Erlangen
Erlangen, , Germany
University Medical Center Hamburg-Eppendorf
Hamburg, , Germany
Heidelberg University
Heidelberg, , Germany
IRCCS Istituto delle Scienze Neurologiche di Bologna
Bologna, , Italy
Egas Moniz Hospital
Lisbon, , Portugal
Centro Hospitalar Universitário de Lisboa Central
Lisbon, , Portugal
Vall D'Hebron
Barcelona, , Spain
Lausanne University Hospital
Lausanne, Canton of Vaud, Switzerland
University Hospital Basel
Basel, , Switzerland
Countries
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References
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Herweh C, Abdalkader M, Nguyen TN, Puetz V, Schone D, Kaiser D, Chen CH, Jeng JS, Mohlenbruch MA, Ringleb PA, Nagel S. Mechanical Thrombectomy in Isolated Occlusion of the Proximal Posterior Cerebral Artery. Front Neurol. 2021 Jul 29;12:697348. doi: 10.3389/fneur.2021.697348. eCollection 2021.
Berberich A, Finitsis S, Strambo D, Michel P, Herweh C, Meyer L, Hanning U, Strbian D, Abdalkader M, Nogueira RG, Puetz V, Kaiser DPO, Olive-Gadea M, Ribo M, Fragata I, Marto JP, Romoli M, Ringleb PA, Nguyen TN, Nagel S. Endovascular therapy versus no endovascular therapy in patients receiving best medical management for acute isolated occlusion of the posterior cerebral artery: A systematic review and meta-analysis. Eur J Neurol. 2022 Sep;29(9):2664-2673. doi: 10.1111/ene.15410. Epub 2022 Jun 17.
Nguyen TN, Qureshi MM, Strambo D, Strbian D, Raty S, Herweh C, Abdalkader M, Olive-Gadea M, Ribo M, Psychogios M, Fischer U, Nguyen A, Kuramatsu JB, Haupenthal D, Kohrmann M, Deuschl C, Kuhne Escola J, Yaghi S, Shu L, Puetz V, Kaiser DPO, Kaesmacher J, Mujanovic A, Marterstock DC, Engelhorn T, Klein P, Haussen DC, Mohammaden MH, Abdelhamid H, Souza Viana L, Cunha B, Fragata I, Romoli M, Diana F, Virtanen P, Lappalainen K, Clark J, Matsoukas S, Fifi JT, Sheth SA, Salazar-Marioni S, Marto JP, Ramos JN, Miszczuk M, Riegler C, Jadhav AP, Desai SM, Maus V, Kaeder M, Siddiqui AH, Monteiro A, Masoud HE, Suryadevara N, Mokin M, Thanki S, Siegler JE, Khalife J, Linfante I, Dabus G, Asdaghi N, Saini V, Nolte CH, Siebert E, Meinel TR, Finitsis S, Mohlenbruch MA, Ringleb PA, Berberich A, Nogueira RG, Hanning U, Meyer L, Michel P, Nagel S. Endovascular Versus Medical Management of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study. Stroke. 2023 Jul;54(7):1708-1717. doi: 10.1161/STROKEAHA.123.042674. Epub 2023 May 24.
Strambo D, Michel P, Nguyen TN, Abdalkader M, Qureshi MM, Strbian D, Herweh C, Mohlenbruch MA, Raty S, Olive-Gadea M, Ribo M, Psychogios M, Fischer U, Nguyen A, Kuramatsu JB, Haupenthal D, Kohrmann M, Deuschl C, Kuhne Escola J, Demeestere J, Lemmens R, Vandewalle L, Yaghi S, Shu L, Puetz V, Kaiser DPO, Kaesmacher J, Mujanovic A, Marterstock DC, Engelhorn T, Requena M, Dasenbrock HH, Klein P, Haussen DC, Mohammaden MH, Abdelhamid H, Souza Viana L, Cunha B, Fragata I, Romoli M, Diana F, Hu W, Zhang C, Virtanen P, Lauha R, Jesser J, Clark J, Matsoukas S, Fifi JT, Sheth SA, Salazar-Marioni S, Marto JP, Ramos JN, Miszczuk M, Riegler C, Poli S, Poli K, Jadhav AP, Desai SM, Maus V, Kaeder M, Siddiqui AH, Monteiro A, Masoud HE, Suryadareva N, Mokin M, Thanki S, Alpay K, Ylikotila P, Siegler JE, Linfante I, Dabus G, Asdaghi N, Saini V, Nolte CH, Siebert E, Serrallach BL, Weyland CS, Hanning U, Meyer L, Berberich A, Ringleb PA, Nogueira RG, Nagel S. Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site. Stroke. 2024 Jul;55(7):1787-1797. doi: 10.1161/STROKEAHA.124.047383. Epub 2024 May 16.
Related Links
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Endovascular Thrombectomy Versus Intravenous Thrombolysis of Posterior Cerebral Artery Occlusion Stroke
Other Identifiers
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H-40712
Identifier Type: -
Identifier Source: org_study_id
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