Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke

NCT ID: NCT04573114

Last Updated: 2021-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-02

Study Completion Date

2022-12-31

Brief Summary

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This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.

Detailed Description

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Conditions

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Stroke Healthy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Stroke subjects

Verticalization

Intervention Type PROCEDURE

Progressive levels of verticalization

Healthy

Verticalization

Intervention Type PROCEDURE

Progressive levels of verticalization

Interventions

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Verticalization

Progressive levels of verticalization

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
* ≤12 hours after mechanical thrombectomy
* Conscious
* Hemodynamically stable
* 18 years or older
* Informed consent of the patient and/ or legal representative

Exclusion Criteria

* Verticalization not allowed according to treating physician
* Known pre-stroke disease affecting cerebral blood flow
* Temporal bone windows insufficient to enable ultrasound penetration
* Intubation anticipated or occurred
* Venous thromboembolism
* Symptomatic intracranial hemorrhage
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andreas Luft, MD

Role: STUDY_CHAIR

University of Zurich

Locations

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University Hospital Zurich

Zurich, Canton of Zurich, Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Jeremia Held, PhD

Role: CONTACT

Phone: 0442555645

Email: [email protected]

Facility Contacts

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Jeremia Held, PhD

Role: primary

References

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Deseoe J, Schwarz A, Pipping T, Lehmann A, Veerbeek JM, Luft AR, Wegener S, Globas C, Held JPO. Cerebral blood flow velocity progressively decreases with increasing levels of verticalization in healthy adults. A cross-sectional study with an observational design. Front Neurol. 2023 Apr 17;14:1149673. doi: 10.3389/fneur.2023.1149673. eCollection 2023.

Reference Type DERIVED
PMID: 37139076 (View on PubMed)

Other Identifiers

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2020-01732

Identifier Type: -

Identifier Source: org_study_id