Impact of Prokinetic Use After Emergency Intestinal Anastomosis on Postoperative Clinical Outcomes

NCT ID: NCT05290753

Last Updated: 2022-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-07-01

Brief Summary

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Prokinetic drugs used to accelerate healing of intestinal anastomosis of urgent cases which not prepared preoperative by increase intestinal motility and gastric emptying and decrease postoperative adhesions They are many types of prokinetics as cholinergic agonists, dopamine antagonist, serotonergic agonists and macrolides Agents of prokinetics administered immediately post operation and at the time of hospitalization

Detailed Description

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By evaluation the effect of prokinetic use versus non use after emergency intestinal intestinal anastomosis on short and long term clinical outcome It will be prospective cohort study which conducted in sohag university hospital Study will include patients presented with urgent anastomosis Inclusion criteria: all adults underwent emergency intestinal anastomosis Exclusion criteria: pediatrics, patients with comorbidities and patients with electively resection and anastomosis.

Primary goals are to detect effect of prokinetics on incidence of leakage rate Secondary outcomes include early bowel opening, enteral feeding, post operative pain, wound infection and adhesion formation rate.

Conditions

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Prokinetic Use After Emergency Intestinal Anastomosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Prokinetic use in accelerate healing of urgent intestinal anastomosis

Prikinetic agents administered immediately post operative and time of stay at hospital twice daily

Group Type OTHER

Prokinetic Motility Agents as primpiram and gastreg

Intervention Type DRUG

Prospective cohort study to evaluate the effect of pro kinetic use in emergency intestinal anastomosis

Interventions

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Prokinetic Motility Agents as primpiram and gastreg

Prospective cohort study to evaluate the effect of pro kinetic use in emergency intestinal anastomosis

Intervention Type DRUG

Other Intervention Names

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Primpiram and gastreg and erythromycin

Eligibility Criteria

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Inclusion Criteria

* all adult patients

Exclusion Criteria

* pediatrics
* patients associated with comorbidities
* patients with electively resection and anastomosis
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Doha Adel Noureldin

Resident doctor at general surgery department sohag university hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alaa eldin Hassan, Professor

Role: STUDY_DIRECTOR

Professor of general surgery

Locations

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Of medicine, Sohag university hospital

Sohag, , Egypt

Site Status

Countries

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Egypt

References

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Acosta A, Camilleri M. Prokinetics in gastroparesis. Gastroenterol Clin North Am. 2015 Mar;44(1):97-111. doi: 10.1016/j.gtc.2014.11.008. Epub 2014 Dec 23.

Reference Type BACKGROUND
PMID: 25667026 (View on PubMed)

Other Identifiers

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Soh-Med-22-02-09

Identifier Type: -

Identifier Source: org_study_id

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